Glycyrrhizin attenuates the development of carrageenan-induced lung injury in mice

Menegazzi, Marta; Paola, Rosanna Di; Mazzon, Emanuela; Genovese, Tiziana; Crisafulli, Concetta; Bosco, Mariachiara; Zou, Zhenzhen; Suzuki, Hisanori; Cuzzocrea, Salvatore

doi:10.1016/j.phrs.2008.05.012

Cited by 102 publications

(71 citation statements)

References 43 publications

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“…It is known that elevated reactive oxygen species production plays a crucial role in STAT-3 activation [42] . In agreement with our results, previous studies demonstrated that GA suppressed activation of STAT-3 in leukemic cells [43] and in a mouse model of acute lung inflammation [44] . The possible mechanism by which GA attenuates diabetes-induced upregulation of pSTAT-3 in the retinas of rats and high-glucose-induced pSTAT-3 upregulation and nuclear translocation in retinal Müller cells may be due to its ability to lower HMGB1-induced oxidative stress.…”

Section: Discussionsupporting

confidence: 93%

High-Mobility Group Box-1 Protein Mediates the Regulation of Signal Transducer and Activator of Transcription-3 in the Diabetic Retina and in Human Retinal Müller Cells

et al. 2016

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Purpose: The expression of high-mobility group box-1 (HMGB1) and signal transducer and activator of transcription-3 (STAT-3) is upregulated in the diabetic retina. We hypothesized that the activation of STAT-3 is under the control of HMGB1. Methods: Retinas from 1-month-old diabetic rats and from normal rats intravitreally injected with HMGB1 and human retinal Müller glial cells (MIO-M1) stimulated with HMGB1 or high glucose were studied by Western blot analysis and immunofluorescence. We also studied the effect of the HMGB1 inhibitor glycyrrhizin (GA) on high-glucose-induced pSTAT-3 nuclear translocation and upregulation in Müller cells and on pSTAT-3 expression in the retinas of diabetic rats (n = 7-10 in each group). In addition, we studied the effect of STAT-3 inhibitor on the HMGB1-induced induction of vascular endothelial growth factor (VEGF) by Müller cells and human retinal microvascular endothelial cell (HRMEC) migration. Results: Treatment of retinal Müller cells with recombinant HMGB1 induced nuclear translocation of pSTAT-3 but did not alter pSTAT-3 expression. High glucose induced a significant upregulation of HMGB1 and pSTAT-3 upregulation and nuclear translocation in retinal Müller cells. GA co-treatment normalized the high-glucose-induced upregulation of HMGB1 and pSTAT-3 upregulation and nuclear translocation in Müller cells. Intravitreal administration of HMGB1 in normal and diabetic rats upregulated pSTAT-3 expression in the retina. GA attenuated the diabetes-induced upregulation of pSTAT-3 in the retina. The STAT-3 inhibitor attenuated HMGB1-induced VEGF upregulation by Müller cells and HRMEC migration. Conclusions: The results suggest a role for HMGB1 in the modulation of STAT-3 expression in the diabetic retina.

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Section: Discussionsupporting

confidence: 93%

High-Mobility Group Box-1 Protein Mediates the Regulation of Signal Transducer and Activator of Transcription-3 in the Diabetic Retina and in Human Retinal Müller Cells

et al. 2016

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“…These mediators promote accumulation of neutrophils and mononuclear cells from blood vessels and activate endothelial cells (Fröde and Medeiros, 2001). In addition, these mediators promote the plasmatic extravasation that contributes to the formation of pleural exudates and migration of leukocytes, which peaked at 4 h after administration of the phlogistic agent Menegazzi et al, 2008). The investigation of antiinflammatory property of EAMC was evaluated in the carrageenan-induced pleurisy.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory property and redox profile of the leaves extract from Morinda citrifolia L.

Serafini¹,

Barreto²,

Brito³

et al. 2015

J. Med. Plants Res.

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Morinda citrifolia Linn (Rubiaceae), popularly known as noni, is widely used in folk medicine in the form of decoction and infusion, particularly as anti-inflammatory, depurative, anti-rheumatic and antiulcer remedy. The infusion of M. citrifolia L. leaves is used in popular medicine in Northeast of Brazil to treat inflammatory and painful diseases. The present study was designed to evaluate the antioxidant potential and the anti-inflammatory effect of the aqueous extract from the dried leaves from M. citrifolia L. (EAMC). The free radical scavenging activities were determined for different concentrations using in vitro models, and the inflammatory processes were evaluated by carrageenan-induced pleurisy. The study results indicated a significant dose-dependent antioxidant effect by noni extract as evaluated by total antioxidant potential (TRAP) and total antioxidant reactivity (TAR) assays. Noni extracts also exhibited modest catalase-like activity, and was able to inhibit the levels of proinflammatory cytokines. All experimental data indicate that the EAMC have not only remarkable antioxidant properties but also potential anti-inflamatory properties.

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“…Though not yet confirmed in a cerebral ischemia model, glycyrrhizin reduced nitrotyrosine in a gut ischemia-reperfusion model [196], carrageenan-induced lung injury in mice [197] and spinal cord compression injury in mice [198]. The inhibitive effects of glycyrrhizin on MMP-9 were also observed in several studies [199,200].…”

Section: Active Compounds From Chinese Herbal Medicine For Targeting mentioning

confidence: 96%

Targeting ONOO<sup>-</sup>/HMGB1/MMP-9 Signaling Cascades: Potential for Drug Development from Chinese Medicine to Attenuate Ischemic Brain Injury and Hemorrhagic Transformation Induced by Thrombolytic Treatment

Chen¹,

Guan²,

Shen³

2016

Integr Med Int

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Stroke is the leading cause of death and disability worldwide, and ischemic stroke accounts for more than 85% of the stroke incidence. Tissue plasminogen activator (t-PA) is the only FDA-approved drug for ischemic stroke treatment with a narrow treatment time window of 4.5 h. Hemorrhagic transformation (HT) is a severe complication of delayed t-PA treatment in ischemic stroke. Thus, it is critically important to develop combination therapies to reduce HT and extend the therapeutic time window of t-PA. Current progress suggests that peroxynitrite (ONOO^-)/high-mobility group box 1 protein (HMGB1)/matrix metalloproteinase-9 (MMP-9) signaling cascades could be important for attenuating HT during thrombolytic treatment for acute ischemic stroke. Recently, important progress has been made in seeking for natural compounds from Chinese medicine for reducing ischemic stroke injury, with some of them targeting ONOO^-/HMGB1/MMP-9 signaling cascades. Herein, we analyze the roles and interactions of these three targets in mediating HT; subsequently, we summarize the potential compounds from Chinese herbal medicine for attenuating HT and analyze the related targets. Finally, we raise the potential issues to be addressed in further development of these compounds as combination therapy.

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Glycyrrhizin attenuates the development of carrageenan-induced lung injury in mice

Cited by 102 publications

References 43 publications

High-Mobility Group Box-1 Protein Mediates the Regulation of Signal Transducer and Activator of Transcription-3 in the Diabetic Retina and in Human Retinal Müller Cells

High-Mobility Group Box-1 Protein Mediates the Regulation of Signal Transducer and Activator of Transcription-3 in the Diabetic Retina and in Human Retinal Müller Cells

Anti-inflammatory property and redox profile of the leaves extract from Morinda citrifolia L.

Targeting ONOO<sup>-</sup>/HMGB1/MMP-9 Signaling Cascades: Potential for Drug Development from Chinese Medicine to Attenuate Ischemic Brain Injury and Hemorrhagic Transformation Induced by Thrombolytic Treatment

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