Glycyrrhizic Acid-Based Liposome for Tumor-Targeted Delivery of Cantharidin
Yuxiang Wang,
Wenzhen Wang,
Hailu Yao
et al.
Abstract:Cantharidin (CTD), an effective ingredient derived from poisonous traditional Chinese medicine Mylabris, shows unique efficacy against hepatocellular carcinoma (HCC), but severe toxicity hinders its clinical application. Liposomes (LPs) are considered to be a platform for the effective delivery of chemotherapeutic agents. Nevertheless, the application of cholesterol, which is usually used to stabilize the structure of LPs, has been compromised due to various drawbacks. Glycyrrhizic acid (GA) has the ability to… Show more
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