Glycyrrhiza uralensis 甘草 (Gancao, Licorice)

Chang, Shoou−Jinn; Chan, Yin-Ching; Yu, Wen-Jen

doi:10.1007/978-3-211-99448-1_14

Cited by 1 publication

(1 citation statement)

References 29 publications

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“…It has long been used as a sedative and diuretic recorded in An Outline Treatise of Medical Herbs, “Compendium of Materia Medica”, as “Poria is the key foundation of PM”, which can guide and support the actions of the formula to target the pathogenetic organs or improve therapeutic efficacy ( Rios, 2011 ). Licorice, another traditional TCM herb, was claimed to coordinate the drug actions in a prescription as well as minimize the toxicity of PM when combined ( Chang et al, 2015 ). Panax notoginseng is also recommended as a typical medicine to invigorate blood ( Li H.Q.…”

Section: Introductionmentioning

confidence: 99%

Poria Attenuates Idiosyncratic Liver Injury Induced by Polygoni Multiflori Radix Praeparata

Gao¹,

Pang²,

Zhang³

et al. 2016

Front. Pharmacol.

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The hepatotoxicity induced by Polygoni Multiflori Radix Praeparata (PM) has aroused great concern throughout the world. Hence, it is worthwhile to perform studies on the detoxification with the combined use of medicinal herbs based on the compatibility theory of traditional Chinese medicine. In this work, the rat model of PM/LPS-induced idiosyncratic liver injury was used. The effects of Poria, Licorice, and Panax notoginseng on rats of PM/LPS-induced liver injury were investigated respectively, hoping to find the most effective herbal medicine to reduce the hepatotoxicity. According to results of biochemical and histological tests, PM could induce the idiosyncratic hepatotoxicity of rats which presented modest inflammation triggered by non-injurious dose of lipopolysaccharide (LPS). We also found that the combined use of Poria and PM in the ratio of 1:2 could significantly ameliorate the PM/LPS-induced liver injury and systemic inflammation. Furthermore, UPLC/QTOF-MS-based metabolomics was performed to identify possible biomarkers and underlying biological pathways. Ten metabolites were expressed differentially among LPS, PM/LPS, and detoxification-treated groups in terms of PCA and OPLS-DA analysis, which could be potential biomarkers. MetaboAnalyst and pathway enrichment analysis revealed that alterations of these metabolites were primarily involved in three pathways: arginine and proline metabolism, primary bile acid biosynthesis and sphingolipid metabolism. This research provides systematic experimental evidences for the hepatoprotective effect of Poria against PM/LPS-induced liver injury for the first time. And these findings may help better understand the underlying mechanisms of pathophysiologic changes in PM/LPS-induced liver injury.

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Section: Introductionmentioning

confidence: 99%