Glycyrrhetinic acid pretreatment attenuates liver ischemia/reperfusion injury via inhibiting TLR4 signaling cascade in mice

Jiang, Xujie; Kuang, Ge; Gong, Xia; Jiang, Rong; Xie, Tianjun; Tie, Hongtao; Wu, Shengwang; Wang, Ting; Wan, Jingyuan; Wang, Bin

doi:10.1016/j.intimp.2019.105870

Cited by 27 publications

(24 citation statements)

References 56 publications

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“…As our experimental model is a warm ischemia model, NF-kappa B staining was seen in hepatocyte cytoplasm. In addition to inflammation in liver IR injuries, apoptotic cell death and necrosis are observed in hepatocytes [33,34]. In our study, both necrotic and apoptotic cell death were observed.…”

Section: Discussionsupporting

confidence: 56%

Protective effect of Coriandrum sativum extract against inflammation and apoptosis in liver ischaemia/reperfusion injury

et al. 2021

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Background: The aim of this study was to investigate the anti-inflammatory and antioxidant effects of Coriandrum sativum extract on liver ischemia reperfusion injury at light microscopic and biochemical levels. Material and methods: Sham, ischemia/reperfusion injury (IRI), IRI+Coriandrum sativum extract and only Coriandrum sativum extract groups were formed. Sixty minutes of ischemia and 60 minutes of reperfusion were performed. In the treatment group, 300 mg/kg/day Coriandrum sativum was given by gavage. Hepatic tissues were fixed in 4% paraformaldehyde. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) enzymes were measured. Nuclear factor-kappa beta (NF-kappa B), Tumor necrosis factor-alpha (TNF-α) and Caspase-3 (Cas-3) Conclusions: It was found that Coriandrum sativum extract decreased proinflammatory cytokine TNF-α and apoptotic cell death and liver enzymes in liver ischemia reperfusion injury.

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Section: Discussionsupporting

confidence: 56%

Protective effect of Coriandrum sativum extract against inflammation and apoptosis in liver ischaemia/reperfusion injury

et al. 2021

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“…Our qPCR data demonstrated that GA treatment during viral infection in mice can suppress the induction of several pro-inflammatory cytokine genes, except IL-1β ( Fig. 3E), which has some different expression in sterile inflammation disease [26].…”

Section: Ga Treatment Abates Mhv-induced Acute Liver Injury and Mortamentioning

confidence: 81%

“…In some sterile hepatic injury diseases, GA attenuates HMGB1-mediated inflammatory by inhibiting TNF-α, IL-1β and IL-6 production [7,26,27]. Pro-inflammatory chemokine IP-10 is a predictive marker of hepatitis C virus (HCV) and HBV infection [28,29].…”

Section: Ga Treatment Abates Mhv-induced Acute Liver Injury and Mortamentioning

confidence: 99%

Glycyrrhetinic acid alleviates hepatic inflammation injury in viral hepatitis disease via a HMGB1-TLR4 signaling pathway

Shi¹,

Yu²,

Zhang³

et al. 2020

International Immunopharmacology

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Various human disorders are cured by the use of licorice, a key ingredient of herbal remedies. Glycyrrhizic acid (GL), a triterpenoid glycoside, is the aqueous extract from licorice root. Glycyrrhetinic acid (GA) has been reported to be a major bioactive hydrolysis product of GL and has been regarded as an anti-inflammatory agent for the treatment of a variety of inflammatory diseases, including hepatitis. However, the mechanism by which GA inhibits viral hepatic inflammatory injury is not completely understood. In this study, we found that, by consecutively treating mice with a traditional herbal recipe, licorice plays an important role in the detoxification of mice. We also employed a murine hepatitis virus (MHV) infection model to illustrate that GA treatment inhibited activation of hepatic inflammatory responses by blocking high-mobility group box 1 (HMGB1) cytokine activity. Furthermore, decreased HMGB1 levels and downstream signaling triggered by injection of a neutralizing HMGB1 antibody or TLR4 gene deficiency, also significantly protected against MHV-induced severe hepatic injury. Thus, our findings characterize GA as a hepatoprotective therapy agent in hepatic infectious disease not only by suppressing HMGB1 release and blocking HMGB1 cytokine activity, but also via an underlying viral-induced HMGB1-TLR4 immunological regulation axis that occurs during the cytokine storm. The present study provides a new therapy strategy for the treatment of acute viral hepatitis in the clinical setting.

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“…Astragaloside I exhibits anti‐inflammatory and antiapoptotic effects on gastric endothelial cells, and could regulate cell invasion and angiogenesis of human gastric adenocarcinoma cells. Glycyrrhetinic acid pre‐treatment could attenuate liver ischemia/reperfusion injury via inhibiting Toll‐like receptor 4 (TLR4) signaling cascade in mice (Jiang et al, ). Other active compounds from different composite herbs have also been evaluated in this work.…”

Section: Resultsmentioning

confidence: 99%

Rapid quantitative analysis of 18 chemical constituents in HuangQi JianZhong Tang based on UHPLC–MS

Jia

Qin

2020

Biomedical Chromatography

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A rapid, highly sensitive, and specific analytical method using ultra‐high‐performance liquid chromatography‐triple quadruple MS was developed to quantitatively measure 18 chemical constituents in Huangqi Jianzhong Tang (HQJZ), a famous traditional Chinese medicine formula. Chromatographic separation was performed on a Waters ACQUITY UPLC HSS T3 column (2.1 mm × 100 mm, 1.8 μm) with a gradient mobile phase (A: 0.1% aqueous formic acid and B: acetonitrile) at a flow rate of 0.25 mL/min. The chromatographic peaks of 18 components were identified by comparing with the reference compounds. Multiple reaction monitoring was employed for quantitative analysis of the components. Seven batches of HQJZ samples were analyzed with a good linear regression relationship (R2, .9978–.9993), precisions [relative standard deviation (RSD), 0.90%–3.60%], repeatability (RSD, 2.50%–4.00%), stability (RSD, 1.00%–4.00%), and recovery (96.10%–104.30%). Based on this established method, the present study offered a highly sensitive, specific, and rapid determination method for identification of 18 compounds, which greatly promoted the systemic quality control of HQJZ.

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Glycyrrhetinic acid pretreatment attenuates liver ischemia/reperfusion injury via inhibiting TLR4 signaling cascade in mice

Cited by 27 publications

References 56 publications

Protective effect of Coriandrum sativum extract against inflammation and apoptosis in liver ischaemia/reperfusion injury

Protective effect of Coriandrum sativum extract against inflammation and apoptosis in liver ischaemia/reperfusion injury

Glycyrrhetinic acid alleviates hepatic inflammation injury in viral hepatitis disease via a HMGB1-TLR4 signaling pathway

Rapid quantitative analysis of 18 chemical constituents in HuangQi JianZhong Tang based on UHPLC–MS

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