Glycyrrhetinic acid attenuates lipopolysaccharide-induced fulminant hepatic failure in d -galactosamine-sensitized mice by up-regulating expression of interleukin-1 receptor-associated kinase-M

Yin, Xinru; Gong, Xia; Zhang, Li; Jiang, Rong; Kuang, Ge; Wang, Bin; Chen, Xinyu; Wan, Jingyuan

doi:10.1016/j.taap.2017.02.011

Cited by 26 publications

(14 citation statements)

References 52 publications

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“…GA is a hydrolysate of glycyrrhizic acid in the aqueous extract of licorice root, which is known to have various immune-modulating and antivirus activities [41]. For example, GA can attenuate LPS-induced fulminant hepatic failure through the deactivation of MAPKs and NF-κB pathway, resulting in the inhibition of TNF-α production [42]. GA also inhibits viral proliferation directly and indirectly in vitro and in vivo [30,43].…”

Section: Discussionmentioning

confidence: 99%

Glycyrrhetinic acid alleviates hepatic inflammation injury in viral hepatitis disease via a HMGB1-TLR4 signaling pathway

Shi¹,

Yu²,

Zhang³

et al. 2020

International Immunopharmacology

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Various human disorders are cured by the use of licorice, a key ingredient of herbal remedies. Glycyrrhizic acid (GL), a triterpenoid glycoside, is the aqueous extract from licorice root. Glycyrrhetinic acid (GA) has been reported to be a major bioactive hydrolysis product of GL and has been regarded as an anti-inflammatory agent for the treatment of a variety of inflammatory diseases, including hepatitis. However, the mechanism by which GA inhibits viral hepatic inflammatory injury is not completely understood. In this study, we found that, by consecutively treating mice with a traditional herbal recipe, licorice plays an important role in the detoxification of mice. We also employed a murine hepatitis virus (MHV) infection model to illustrate that GA treatment inhibited activation of hepatic inflammatory responses by blocking high-mobility group box 1 (HMGB1) cytokine activity. Furthermore, decreased HMGB1 levels and downstream signaling triggered by injection of a neutralizing HMGB1 antibody or TLR4 gene deficiency, also significantly protected against MHV-induced severe hepatic injury. Thus, our findings characterize GA as a hepatoprotective therapy agent in hepatic infectious disease not only by suppressing HMGB1 release and blocking HMGB1 cytokine activity, but also via an underlying viral-induced HMGB1-TLR4 immunological regulation axis that occurs during the cytokine storm. The present study provides a new therapy strategy for the treatment of acute viral hepatitis in the clinical setting.

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Section: Discussionmentioning

confidence: 99%

Glycyrrhetinic acid alleviates hepatic inflammation injury in viral hepatitis disease via a HMGB1-TLR4 signaling pathway

Shi¹,

Yu²,

Zhang³

et al. 2020

International Immunopharmacology

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“…These pharmacological effects were due to an increase in the secretion of serotonin and prostaglandins in the stomach that led to a decrease of gastric inflammation (Bahmani et al, ). Different authors described that the anti‐inflammatory action is primary mediated by glycyrrhizin, which in vitro could inhibit factors responsible for inflammation as well as promote the healing of stomach and mouth ulcers (Rackova et al, ; Yin et al, ). In fact, the anti‐inflammatory effects of glycyrrhizin were described as similar to those of glucocorticoids and mineralocorticoids (Kageyama, Suzuki, & Saruta, ).…”

Section: Pharmacological Propertiesmentioning

confidence: 97%

“…According to Rizzato et al (), glycyrrhizin and glycyrrhetinic acids prevent drug‐induced liver injury and ensure the disruption of bile acid metabolism in humans. Indeed glycyrrhetinic acid has been reported as anti‐inflammatory and hepatoprotective compound (Yin et al, ), whereas glycyrrhizin, when compared with the placebo, induced a significant reduction in the serum aminotransferases and improved the liver histology (van Rossum et al, ). It has also been reported that the long‐term use of glycyrrhizin prevents the development of hepatocellular carcinoma in chronic hepatitis C (van Rossum et al, ).…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review

Pastorino

Cornara

Soares

et al. 2018

Phytotherapy Research

508

332

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In the last years, consumers are paying much more attention to natural medicines and principles, mainly due to the general sense that natural compounds are safe. On the other hand, there is a growing demand by industry for plants used in traditional medicine that could be incorporated in foods, nutraceuticals, cosmetics, or even pharmaceuticals. Glycyrrhiza glabra Linn. belongs to the Fabaceae family and has been recognized since ancient times for its ethnopharmacological values. This plant contains different phytocompounds, such as glycyrrhizin, 18β-glycyrrhetinic acid, glabrin A and B, and isoflavones, that have demonstrated various pharmacological activities. Pharmacological experiments have demonstrated that different extracts and pure compounds from this species exhibit a broad range of biological properties, including antibacterial, anti-inflammatory, antiviral, antioxidant, and antidiabetic activities. A few toxicological studies have reported some concerns. This review addresses all those issues and focuses on the pharmacological activities reported for G. glabra. Therefore, an updated, critical, and extensive overview on the current knowledge of G. glabra composition and biological activities is provided here in order to explore its therapeutic potential and future challenges to be utilized for the formulation of new products that will contribute to human well-being.

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“…Anti‐apoptotic activity of NO is more evident in D‐GalN/TNF models of apoptosis while iNOS plays a vital hepatoprotective role in Fas‐mediated apoptosis induced by D‐GalN/LPS (Dufour & Clavien, ). The use of the transcriptional inhibitor D‐GalN along with the endotoxin LPS and TNF to produce typical apoptosis and necrosis is an elite model to provide insight on the progression of fulminant hepatic failure and ALF (Furuya et al, ; Yin et al, ). In addition, D‐GalN/LPS and D‐GalN/TNF models have been used as a positive control for apoptosis in several studies (Jaeschke, ; McGill, Sharpe, et al, ).…”

Section: Means Of Chemical Modulation Of Hepatic Apoptosismentioning

confidence: 99%

Chemical induction of hepatic apoptosis in rodents

Qinna

Ghanim

2018

J of Applied Toxicology

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The urge of identifying new pharmacological interventions to prevent or attenuate liver injury is of critical importance and needs an expanded experimental toolbox. Hepatocyte injury and cellular death is a prominent feature behind the pathology of liver diseases. Several research activities focused on identifying chemicals and hepatotoxicants that induce cell death by apoptosis, in addition to presenting its corresponding signaling pathway. Although such efforts provided further understanding of the mechanisms of cell death, it has also raised confusion concerning identifying the involvement of several modes of cell death including apoptosis, necrosis and fibrosis. The current review highlights the ability of several chemicals and potential hepatotoxicants to induce liver damage in rodents by means of apoptosis while the probable involvement of other modes of cell death is also exposed. Thus, several chemical substances including hepatotoxins, mycotoxins, hyperglycemia inducers, metallic nanoparticles and immunosuppressant drugs are reviewed to explore the hepatic cytotoxic spectrum they could exert on hepatocytes of rodents. In addition, the current review address the mechanism by which hepatotoxicity is initiated in hepatocytes in different rodents aiding the researcher in choosing the right animal model for a better research outcome.

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Glycyrrhetinic acid attenuates lipopolysaccharide-induced fulminant hepatic failure in d -galactosamine-sensitized mice by up-regulating expression of interleukin-1 receptor-associated kinase-M

Cited by 26 publications

References 52 publications

Glycyrrhetinic acid alleviates hepatic inflammation injury in viral hepatitis disease via a HMGB1-TLR4 signaling pathway

Glycyrrhetinic acid alleviates hepatic inflammation injury in viral hepatitis disease via a HMGB1-TLR4 signaling pathway

Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review

Chemical induction of hepatic apoptosis in rodents

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