Glycosylation of immunoglobin G in tumors: Function, regulation and clinical implications

Yang, Sen; Cui, Ming; Liu, Qiaofei; Liao, Quan

doi:10.1016/j.canlet.2022.215902

Cited by 8 publications

(4 citation statements)

References 158 publications

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“…Additionally, the CPG-H group exhibited considerably higher levels (p < 0.05) of the tumor-specific IgG antibody compared with the model group, which was different from the non-significant variation in the IgM antibody. Considering the tumor development processes in these groups, it could be deduced that IgM antibodies presented non-specific inhibitory effects on tumor cells, while IgG antibodies might play more critical roles in the clearance of tumor cells [28,29]. However, no correlation was observed between the IgA antibody in sera and tumor antigens in this study.…”

Section: Toxic Effects Of Mouse Sera On S180 Cellscontrasting

confidence: 61%

Systemic Immunomodulatory Effects of Codonopsis pilosula Glucofructan on S180 Solid-Tumor-Bearing Mice

Fan,

Long,

Gong

et al. 2023

IJMS

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The immune functions of the body are intricately intertwined with the onset and advancement of tumors, and immunotherapy mediated by bioactive compounds has exhibited initial effectiveness in overcoming chemotherapy resistance and inhibiting tumor growth. However, the comprehensive interpretation of the roles played by immunologic components in the process of combating tumors remains to be elucidated. In this study, the Codonopsis pilosula glucofructan (CPG) prepared in our previous research was employed as an immunopotentiator, and the impacts of CPG on both the humoral and cellular immunity of S180 tumor-bearing mice were investigated. Results showed that CPG administration of 100 mg/kg could effectively inhibit tumor growth in mice with an inhibitory ratio of 45.37% and significantly improve the expression of Interleukin-2 (IL-2), Interferon-γ (IFN-γ), and Tumor Necrosis Factor-α (TNF-α). Additionally, CPG clearly enhanced B-cell-mediated humoral immunity and immune-cell-mediated cellular immunity, and, finally, induced S180 cell apoptosis by arresting cells in the G0/G1 phase, which might result from the IL-17 signaling pathway. These data may help to improve comprehension surrounding the roles of humoral and cellular immunity in anti-tumor immune responses.

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Section: Toxic Effects Of Mouse Sera On S180 Cellscontrasting

confidence: 61%

Systemic Immunomodulatory Effects of Codonopsis pilosula Glucofructan on S180 Solid-Tumor-Bearing Mice

Fan,

Long,

Gong

et al. 2023

IJMS

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“…In recent years, the glycoproteome mapping provides innovative insights into the both peptides and glycosylation status in diseases and contributes to biomarker discovery. As the predominant constituent in immune molecule, Ig glycosylation especially fucosylation variations were found to be closely associated with the development of HBV-HCC using glycoproteomics [ 43 ]. Core-fucosylated serum IgG was significantly increased in HBV-HCC compared to HBV-related cirrhosis, HBV carriers and healthy subjects, and have general diagnostic performance than AFP in the training set and validation cohorts [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Integrating transcriptomics, glycomics and glycoproteomics to characterize hepatitis B virus-associated hepatocellular carcinoma

Li,

Zhang,

Dong

et al. 2024

Cell Commun Signal

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Background Hepatocellular carcinoma (HCC) ranks as the third most common cause of cancer related death globally, representing a substantial challenge to global healthcare systems. In China, the primary risk factor for HCC is the hepatitis B virus (HBV). Aberrant serum glycoconjugate levels have long been linked to the progression of HBV-associated HCC (HBV-HCC). Nevertheless, few study systematically explored the dysregulation of glycoconjugates in the progression of HBV-associated HCC and their potency as the diagnostic and prognostic biomarker. Methods An integrated strategy that combined transcriptomics, glycomics, and glycoproteomics was employed to comprehensively investigate the dynamic alterations in glyco-genes, N-glycans, and glycoproteins in the progression of HBV- HCC. Results Bioinformatic analysis of Gene Expression Omnibus (GEO) datasets uncovered dysregulation of fucosyltransferases (FUTs) in liver tissues from HCC patients compared to adjacent tissues. Glycomic analysis indicated an elevated level of fucosylated N-glycans, especially a progressive increase in fucosylation levels on IgA1 and IgG2 determined by glycoproteomic analysis. Conclusions The findings indicate that the abnormal fucosylation plays a pivotal role in the progression of HBV-HCC. Systematic and integrative multi-omic analysis is anticipated to facilitate the discovery of aberrant glycoconjugates in tumor progression.

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“…Furthermore, WSAA combined groups also showed higher B cells proportions and proliferation abilities, as well as IgG antibodies levels, and finally resulted in higher inhibitory effects on tumor cells. Based on the evaluation of tumor development in different groups of mice, it can be inferred that IgM antibodies did not exhibit any distinct inhibitory effects on tumor cells, while IgG antibodies played a more significant role in effectively eliminating tumor cells [ 41 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

The Protective Effects of Water-Soluble Alginic Acid on the N-Terminal of Thymopentin

Ji,

Fan,

Gao

et al. 2023

Molecules

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Thymopentin (TP5) has exhibited strong antitumor and immunomodulatory effects in vivo. However, the polypeptide is rapidly degraded by protease and aminopeptidase within a minute at the N-terminal of TP5, resulting in severe limitations for further practical applications. In this study, the protective effects of water-soluble alginic acid (WSAA) on the N-terminal of TP5 were investigated by establishing an H22 tumor-bearing mice model and determining thymus, spleen, and liver indices, immune cells activities, TNF-α, IFN-γ, IL-2, and IL-4 levels, and cell cycle distributions. The results demonstrated that WSAA+TP5 groups exhibited the obvious advantages of the individual treatments and showed superior antitumor effects on H22 tumor-bearing mice by effectively protecting the immune organs, activating CD4+ T cells and CD19+ B cells, and promoting immune-related cytokines secretions, finally resulting in the high apoptotic rates of H22 cells through arresting them in S phase. These data suggest that WSAA could effectively protect the N-terminal of TP5, thereby improving its antitumor and immunoregulatory activities, which indicates that WSAA has the potential to be applied in patients bearing cancer or immune deficiency diseases as a novel immunologic adjuvant.

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Glycosylation of immunoglobin G in tumors: Function, regulation and clinical implications

Cited by 8 publications

References 158 publications

Systemic Immunomodulatory Effects of Codonopsis pilosula Glucofructan on S180 Solid-Tumor-Bearing Mice

Systemic Immunomodulatory Effects of Codonopsis pilosula Glucofructan on S180 Solid-Tumor-Bearing Mice

Integrating transcriptomics, glycomics and glycoproteomics to characterize hepatitis B virus-associated hepatocellular carcinoma

The Protective Effects of Water-Soluble Alginic Acid on the N-Terminal of Thymopentin

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