Glycosylated Zein Composite Nanoparticles for Efficient Delivery of Betulinic Acid: Fabrication, Characterization, and In Vitro Release Properties

Peng, Fei; Jin, Yang; Wang, Kunhua; Wang, Xiaojing; Xiao, Yaqing; Xu, Huaide

doi:10.3390/foods11172589

Cited by 4 publications

(4 citation statements)

References 51 publications

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“…The nanocomplexes were diluted to a 20 μg/ mL concentration with deionized water, and then dripped on 230-mesh copper grids. After drying naturally, the samples were imagined by TEM (JEM-1230, JEOL, Tokyo, Japan) at 80 kV to assess the microstructure of the 7S-Cur and 7S-150-Cur nanocomplexes [ 22 ].…”

Section: Methodsmentioning

confidence: 99%

Glycated Soy β-Conglycinin Nanoparticle for Efficient Nanocarrier of Curcumin: Formation Mechanism, Thermal Stability, and Storage Stability

Wang

et al. 2022

Foods

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In this study, soy β-conglycinin (7S) was glycated with dextran of different molecular masses (40, 70, 150, 500 kDa) by the dry-heating method to synthesize soy β-conglycinin-dextran (7S-DEX) conjugates. The curcumin (Cur) loaded nanocomplexes were prepared based on 7S-DEX conjugates by a pH-driven self-assemble strategy to enhance the solubility and thermal stability of curcumin. Results showed that the 7S-150 conjugates (glycated from 7S with dextran (150 kDa)) could remain stable in the pH 3.0–pH 8.0 range and during the heat treatment. The results of fluorescence quenching and FT-IR indicated that glycated 7S were combined with curcumin mainly by hydrogen bonding and hydrophobic interaction, and 7S-150 conjugates had higher binding affinity than natural 7S for curcumin. The loading capacity (μg/mg) and encapsulation efficiency (EE%) of 7S-150-Cur were 16.06 μg/mg and 87.51%, respectively, significantly higher than that of 7S-Cur (12.41 μg/mg, 51.15%). The XRD spectrum showed that curcumin was exhibited in an amorphous state within the 7S-150-Cur nanocomplexes. After heating at 65 °C for 30 min, the curcumin retention of the 7S-150-Cur nanocomplexes was about 1.4 times higher than that of free curcumin. The particle size of 7S-150-Cur nanocomplexes was stable (in the range of 10–100 nm) during the long storage time (21 days).

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Section: Methodsmentioning

confidence: 99%

Glycated Soy β-Conglycinin Nanoparticle for Efficient Nanocarrier of Curcumin: Formation Mechanism, Thermal Stability, and Storage Stability

Wang

et al. 2022

Foods

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“…It was also demonstrated that BA NPs may inhibit glioma cell proliferation and that the therapeutic effect of BA NPs is influenced by the presence of CB1/CB2 receptors on the surface of glioblastoma cells [72]. BA was also encapsulated in glycosylated zein (GZ) NPs (BA-GZ NPs) [70]. Zein is a natural, biocompatible, and biodegradable polymer widely used in the pharmaceutical, biomedical, and packaging fields because of its low water vapor permeability, antibacterial activity, and hydrophobicity [103].…”

Section: Polymeric Npsmentioning

confidence: 99%

“…BA was also encapsulated in glycosylated zein (GZ) NPs (BA-GZ NPs) [ 70 ]. Zein is a natural, biocompatible, and biodegradable polymer widely used in the pharmaceutical, biomedical, and packaging fields because of its low water vapor permeability, antibacterial activity, and hydrophobicity [ 103 ].…”

Section: Delivery Systemsmentioning

confidence: 99%

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Drug Delivery Systems of Betulin and Its Derivatives: An Overview

Jaroszewski,

Jelonek,

Kasperczyk

2024

Biomedicines

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Natural origin products are regarded as promising for the development of new therapeutic therapies with improved effectiveness, biocompatibility, reduced side effects, and low cost of production. Betulin (BE) is very promising due to its wide range of pharmacological activities, including its anticancer, antioxidant, and antimicrobial properties. However, despite advancements in the use of triterpenes for clinical purposes, there are still some obstacles that hinder their full potential, such as their hydrophobicity, low solubility, and poor bioavailability. To address these concerns, new BE derivatives have been synthesized. Moreover, drug delivery systems have emerged as a promising solution to overcome the barriers faced in the clinical application of natural products. The aim of this manuscript is to summarize the recent achievements in the field of delivery systems of BE and its derivatives. This review also presents the BE derivatives mostly considered for medical applications. The electronic databases of scientific publications were searched for the most interesting achievements in the last ten years. Thus far, it is mostly nanoparticles (NPs) that have been considered for the delivery of betulin and its derivatives, including organic NPs (e.g., micelles, conjugates, liposomes, cyclodextrins, protein NPs), inorganic NPs (carbon nanotubes, gold NPs, silver), and complex/hybrid and miscellaneous nanoparticulate systems. However, there are also examples of microparticles, gel-based systems, suspensions, emulsions, and scaffolds, which seem promising for the delivery of BE and its derivatives.

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Self-constructed water-in-oil Pickering emulsions as a tool for increasing bioaccessibility of betulin

Zeng,

Wang,

Liu

et al. 2024

Food Chemistry: X

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Glycosylated Zein Composite Nanoparticles for Efficient Delivery of Betulinic Acid: Fabrication, Characterization, and In Vitro Release Properties

Cited by 4 publications

References 51 publications

Glycated Soy β-Conglycinin Nanoparticle for Efficient Nanocarrier of Curcumin: Formation Mechanism, Thermal Stability, and Storage Stability

Glycated Soy β-Conglycinin Nanoparticle for Efficient Nanocarrier of Curcumin: Formation Mechanism, Thermal Stability, and Storage Stability

Drug Delivery Systems of Betulin and Its Derivatives: An Overview

Self-constructed water-in-oil Pickering emulsions as a tool for increasing bioaccessibility of betulin

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