Glycosylated Porphyrins, Phthalocyanines, and Other Porphyrinoids for Diagnostics and Therapeutics

Abstract

Graphical Abstract

Activatable Photosensitizers: Agents for Selective Photodynamic Therapy

“…[12,13] Because they have an extended conjugated electronic structure, Pcs exhibit enhanced absorption at wavelengths around 670 nm (ε ≈ 10 5 L mol −1 cm −1 ), which are longer than those of most porphyrins (λ max ≈ 610 nm, ε ≈ 5 × 10 3 L mol −1 cm −1 ) and that penetrate deeper into biological tissues. [14] Specificity required for the applications of Pcs can be governed by modification of the peripheral aromatic rings, by the nature of central chelated metal ions and even by altering the axial ligands. Pcs that have been probed as PSs for PDT include derivatives of zinc(II)-phthalocyanine (ZnPc), silicon(IV)-phthalocyanine (SiPc), and aluminum(III)-phthalocyanine (AlPc).…”

Synthesis of Water-Soluble Non-Aggregated Porphyrin-β-Cyclodextrin Tetraconjugate

“…[1][2][3][4][5][6][7][8][9][10][11][12] The specific biological (tendency to accumulate in cancer tissues) and spectroscopic (high molar absorption, strong fluorescence and good quantum yields) properties of porphyrins predetermine their medical applications mostly focused on photodynamic diagnostic and photodynamic therapy (PDT). [13][14][15][16] The photoactivity of many photosensitizers in PDT is affected by their poor solubility and aggregation, which leads to a decrease in their singlet oxygen production. The considerable use of CDs as individualized entities in medicine is undeniably and have a long history.…”

(2-Deoxy-2-{[2-(2-pyridinyl-κN)-4-thiazolecarbonyl-κN3]amino}-α-d-glucopyranose)dichloropalladium(II) Methanol Solvate

“…Glycoconjugated transition-metal complexes have played an important role in bioinorganic and biomedicinal chemistry [1][2][3][4]. In the context of our recent research on complexes of group 10 metals with sugar-conjugated ligands as antitumor metallo-drugs [5,6], we have synthesized a novel glycoconjugated palladium complex and have successfully determined its crystal structure.…”