Glycosylated haemoglobin in the assessment of diabetic control in pregnancy

Delayed menarche as an indicator of a prediabetic state

“…Our conclusions therefore agree with Kbbberling et al [3] in that the chlorpropamide alcohol flush test is unsuitable for genetic counselling and should not be used for the prognostic labelling of non-insulin dependent diabetic patients. …”

“…Dear Sir, Leslie and Pyke have suggested that the chlorproparnide alcohol flush is a dominantly inherited trait in non-insulin dependent diabetics which is associated with a low prevalence of severe retinopathy [1,2], K6bberling and his colleagues have recently been unable to confirm these observations [3]. They found that the chlorpropamide alcohol flush was not specific for non-insulin dependent diabetics and they were unable to find any differences in the distribution of the chlorpropamide alcohol flush in diabetics with or without a family history of the disease.…”

“…There are also reports that oestrogen increases the sensitivity of adipose tissue and skeletal muscle to the action of insulin [2]. This may explain why ovariectomy increases the incidence and severity of experimental diabetes in female animals [3].…”

Cord blood C-peptide: Glucose ratio ? A good indicator of B cell function in infants of diabetic mothers

“…We too, have measured cord blood C-peptide and glucose, the former after initial precipitation of insulin antibodies with polyethylene glycol [2], to compare the true B cell response of a group of 44 infants of insulinrequiring diabetic mothers with 32 infants of non-diabetic mothers. We divided the infants of diabetic mothers into two groups dependent upon the quality of their mothers' blood glucose control and their glycosylated haemoglobin concentration [3] and not on the basis of the presence or absence of insulin antibodies. The results are presented below as group means + one standard deviation.…”