Glycosyl Inositol Derivatives Related to Inositolphosphoglycan Mediators: Synthesis, Structure, and Biological Activity

Purification and Characterization of Insulin-Mimetic Inositol Phosphoglycan-Like Molecules From Grass Pea (Lathyrus sativus) Seeds

“…Free amino and phosphate groups within the eluted GPI were estimated as previously described (15). The stoichiometry of sugar residues within GPI was determined using orcinol/ sulphuric acid with reference to authentic synthetic IPG analog standards (16,17). To determine the fatty acid composition of the purified GPI, gas chromatography-mass spectrometry (GC/MS) was used as previously described (18).…”

A Practical Solid‐Phase Synthesis of Glycosylphosphatidylinositol Precursors

“…Under these general conditions pseudo‐oligosaccharides 1 , 2 and 3 have been prepared by sequential glycosylation starting from pseudodisaccharide 4 . Compound 4 can be obtained in multigram quantities 10b,c. The formation of the glucosamine α1→6 myoinositol linkage with complete selectivity is difficult to achieve 10b.…”

A potassium–18-crown-6 salt of a cyclicmyo-inositol phosphate

“…Our interest lies mainly in cyclic phosphorus compounds (Kumara Swamy et al, 1998;Muthiah & Kumara Swamy, 1999) and in this connection we felt that various cyclic phosphates could be generated from suitably protected inositol derivatives. It should be noted that, despite so much interest in inositol phosphates, few cyclic derivatives have been structurally characterized, although the crystal structures of two cyclic phosphates derived from inositol have been reported recently (Dietrich et al, 1999;Neidle et al, 1998). In the present paper, we report the structure of a cyclic inositol phosphate as a trihydrate of its potassium±18-crown-6 salt, viz.…”