Glycosides from Marine Sponges (Porifera, Demospongiae): Structures, Taxonomical Distribution, Biological Activities and Biological Roles

Kalinin, Vladimir I.; Ivanchina, Natalia V.; Krasokhin, Vladimir B.; Makarieva, Tatyana N.; Stonik, Valentin A.

doi:10.3390/md10081671

Cited by 45 publications

(42 citation statements)

References 103 publications

(181 reference statements)

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“…and Erylus spp. In fact, the both these sponge groups contain penasterol derivatives in free (Penares) or glycosylated (Erylus) forms [18]. Moreover, the characteristic features of aglycone biosynthesis such as 30,9-lactonization followed by 7,8-epoxidation and oxidation in side chain in some Erylus sponges [19] are the same as of triterpenoids from the Vietnamese Penares sp., studied by us.…”

Section: Resultsmentioning

confidence: 99%

Further study on Penares sp. from Vietnamese waters: Minor lanostane and nor-lanostane triterpenes

et al. 2015

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Section: Resultsmentioning

confidence: 99%

Further study on Penares sp. from Vietnamese waters: Minor lanostane and nor-lanostane triterpenes

et al. 2015

Self Cite

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“…Mycalosides A-I (172-180) have displayed activity as spermostatics, inhibiting the fertilisation of sea urchin (Strongylocentrotus nudus) eggs, with individual glycosides showing EC 50 values of 32 µg/mL [125]. Sponge glycosides have shown biological activities leading to the conclusion that they can serve multiple ecological roles such as feeding deterrents, prevention of biofilm formation, chemical signalling, and allelopathy (see [139] for a review of activities).…”

Section: Steroid Glycosidesmentioning

confidence: 99%

Chemical and Biological Aspects of Marine Sponges from the Family Mycalidae

2016

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Sponges are a useful source of bioactive natural products. Members of the family Mycalidae, in particular, have provided a variety of chemical structures including alkaloids, polyketides, terpene endoperoxides, peptides, and lipids. This review highlights the compounds isolated from Mycalid sponges and their associated biological activities. A diverse group of 190 compounds have been reported from over 40 specimens contained in 49 references. Over half of the studies have reported on the biological activities for the compounds isolated. The polyketides, in particular the macrolides, displayed potent cytotoxic activities (

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“…The relative activity of the enzyme against pNPbGlc was examined at pH values of 2-10. The substrates were dissolved in either 50 mM potassium chloride-HCl (pH 2), 50 mM Tris-HCl (pH [3][4][5][6][7][8] or 50 mM glycine-NaOH (pH 9-10). The optimal temperature was determined by examining b-glucosidase activity in 50 mM Tris-HCl buffer (pH 6) at temperatures ranging from 25 to 45°C.…”

Section: Characterization Of Bglcmentioning

confidence: 99%

“…Moreover, marine glycoside compounds have diverse aglycone and carbohydrate moiety structures compared with their terrestrial origin. Marine glycosides may have several biological functions including antiprotozoal, antifungal and antitumor [8]. However, marine biomass contains a high salt concentration, which is detrimental to the activity and stability of most known b-glucosidases [9].…”

Section: Introductionmentioning

confidence: 99%

Characterization of salt-tolerant β-glucosidase with increased thermostability under high salinity conditions from Bacillus sp. SJ-10 isolated from jeotgal, a traditional Korean fermented seafood

Lee

Kim²,

Kim

et al. 2015

Bioprocess Biosyst Eng

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The β-glucosidase gene, bglC, was cloned from Bacillus sp. SJ-10 isolated from the squid jeotgal. Recombinant BglC protein overexpression was induced in Escherichia coli. The optimal pH and temperature of the enzyme, using p-nitrophenyl-β-D-glucopyranoside (pNPβGlc) as a substrate, were pH 6 and 40 °C, respectively. Enzymatic activity increased by 3.3- and 3.5-fold in the presence of 15% NaCl and KCl, respectively. Furthermore, enzyme thermostability improved in the presence of NaCl or KCl. At 45 °C in the presence of salts, the enzyme was stable for 2 h and maintained 80% activity. In the absence of salts, BglC completely lost activity after 110 min at 45 °C. Comparison of the kinetic parameters at various salt concentrations revealed that BglC had approximately 1.5- and 1.2-fold higher affinity and hydrolyzed pNPβGlc 1.9- and 2.1-fold faster in the presence of 15% NaCl and KCl, respectively. Additionally, the Gibb's free energy for denaturation was higher in the presence of 15% salt than in the absence of salt at 45 and 50 °C. Since enzymatic activity and thermostability were enhanced under high salinity conditions, BglC is an ideal salt-tolerant enzyme for further research and industrial applications.

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Glycosides from Marine Sponges (Porifera, Demospongiae): Structures, Taxonomical Distribution, Biological Activities and Biological Roles

Abstract: Literature data about glycosides from sponges (Porifera, Demospongiae) are reviewed. Structural diversity, biological activities, taxonomic distribution and biological functions of these natural products are discussed.

Cited by 45 publications

References 103 publications

Further study on Penares sp. from Vietnamese waters: Minor lanostane and nor-lanostane triterpenes

Further study on Penares sp. from Vietnamese waters: Minor lanostane and nor-lanostane triterpenes

Chemical and Biological Aspects of Marine Sponges from the Family Mycalidae

Characterization of salt-tolerant β-glucosidase with increased thermostability under high salinity conditions from Bacillus sp. SJ-10 isolated from jeotgal, a traditional Korean fermented seafood

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