Glycoside derivatives of scopoletin and β-sitosterol from Hymenodictyon floribundum

Mitaine-Offer, Anne Claire; Tapondjou, Léon Azefack; Djoukeng, Jules Désiré; Bouda, H.; Lacaille‐Dubois, Marie‐Aleth

doi:10.1016/s0305-1978(02)00086-8

Cited by 6 publications

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“…such as Acer saccharum Marsh 45 , Aegle marmelos 30 , Aleurites moluccana (L.) 46 , Arabidopsis thaliana 47 , Artemisia annua 48 , Artemisia feddei 49 , Artemisia iwayomogi 50 , Brunfelsia hopeana 51 , Canscora decussate 52 , Chenopodium murale 53 , Cirsium setidens 54 , Clausena excavate Burm.f. (Pyin-daw-thein) 55 , Convolvulus prostrates 56 , Erycibe obtusifolia Benth 9 , Fagraea ceilanica 57 , Gossypium hirsutum 58 , Hevea brasiliensis 59 , Hedyotis capitellata 60 , Helianthus anuus 61 , Helichrysum italicum 62 , Hymenodictyon floribundum 63 , Hymenodictyon obovatum 64 , Hypochaeris radicata 65 , Ipomoea batatas 66 , Ipomoea digitata 67 , Ipomoea reniformis 68 , Lasianthus lucidus Blume1, Macaranga gigantifolia Merr 69 , Magnolia fargesii 70 , Manihot esculenta 71 , Melia azedarach L. 20 , Morinda citrifolia 12 , Morus alba L. (Po-sa) 72 , Nicotiana tabacum 73 , Scaphopetalum thonneri 74 , Sinomonium acutum 29 , Solanum lyratum 39 , Tetrapleura tetraptera 75 , Tilia cordata Mill 76 , Ulmus pumila, Ulmus campestris 77 , Viburnum tinus 78 .…”

Section: Fig 1: Chemical Structure Of Scopoletinunclassified

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2021

IJPSR

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Scopoletin (7-hydroxy-6-methoxy coumarin) is a phenolic coumarin isolated from many plants, known as an important compound of the phytoalexin group. This article is created to provide information regarding the synthesis and pharmacological activity of scopoletin. Scopoletin has been found in many plant species and isolated from various parts of the plant (roots, fruits, leaves, stems, etc.) such as Morinda citrifolia, Aegle marmelos, Erycibe obtusifolia Benth, Lasianthus lucidus Blume, Melia azedarach L., Sinomonium acutum, Convolvulus prostratus, and Solanum lyratum, etc. which all possess a number of medicinal properties. Its various pharmacological activities have been reported through a number of investigations. It is reported that such compounds produced specific biological activities and possible health implications for humans in food and medicine. Pharmacological activities that are established in-vivo are antithyroid, antihypertensive, anti-proliferative, anti-inflammatory, neurological, anti-dopaminergic and anti-adrenergic, antidiabetic drug, and antihyperuricemic activities. Based on in-vitro studies, scopoletin has pharmacological activities, including an antihepatotoxicity, antibacterial, antifungal, antitubercular, and antioxidant. From the assorted pharmacological activities of scopoletin, it has the potential to be further developed.INTRODUCTION: Scopoletin (7-hydroxy-6methoxy coumarin) is a phenolic coumarin isolated from many plants, known as an important compound of the phytoalexin group. It has a yellow crystalline structure with a molecular weight of 192 and a melting point of 204-206 °C. Its various biological activities have been reported through a number of investigations. Booth et al., (2004) reported that such compounds produced specific biological activities and possible health implications for humans in food and medicine.

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Section: Fig 1: Chemical Structure Of Scopoletinunclassified

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2021

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“…Kariba (2002) revealed that the extracts from H. parvifolium had antifungal and antibacterial properties. Furthermore, hymexelsin (also called xeroboside), which is a glycoside derivative of scopoletin and β‐sitosterol, has been found in both H. floribundum (Mitaine‐Offer et al ., 2003) and H. orixense (Rao et al ., 1988). In contrast, no local uses of any Malagasy Hymenodictyon and Paracorynanthe species have been recorded in Madagascar.…”

Section: Morphological and Other Important Characteristics Of Hymenodmentioning

confidence: 99%

Taxonomic revision of the tribe Hymenodictyeae (Rubiaceae, Cinchonoideae)

Razafimandimbison

Bremer

2006

Botanical Journal of the Linnean Society

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The palaeotropical tribe Hymenodictyeae Razafim. & B. Bremer, belonging to the otherwise predominantly Neotropical subfamily Cinchonoideae s.s. (coffee family or Rubiaceae), is revised here. The tribe as presently circumscribed contains two genera, Hymenodictyon Wall. and Paracorynanthe Capuron ex J.-F. Leroy, and is distinct from the other Cinchonoideae tribes with capsular fruits in having stipules bearing large, deciduous colleters on the margins, valvate corolla aestivation, and lenticellate capsular fruits that contain elongate, bilaterally flattened, and accrescent placentae. We recognize 22 Hymenodictyon species, including four new species ( H. antakaranensis sp. nov. , H. epiphyticum sp. nov. , H. madagascaricum sp. nov. , and H. tsingy sp. nov. ), and the two described species of Paracorynanthe . Hymenodictyon is distinguished from its sister genus, Paracorynanthe , by simple or compound spicate, racemose or thyrsoid inflorescences and corolla lobes without any appendages, rather than compound umbelliform inflorescences and corolla lobes prolonged by ciliate appendages. A full taxonomic treatment, keys, and distribution maps of all recognized Hymenodictyon and Paracorynanthe species are provided. Five lectotypes and one neotype are designated. Finally, six Hymenodictyon species are illustrated for the first time.

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“…Anthelmintic resistance is considered a major challenge in most sheep-rearing countries [17]. The current alternative and approach to reduce anthelmintic resistance is: phototherapy, use of medicinal and herbal plants (leaves, stem, barks, roots and seeds) to formulate good alternative herbal preparations with high anthelmintic effects that will complement the commercial anthelmintics [14,25,34] [2,7,8,23,32].…”

Section: Introductionmentioning

confidence: 99%

Anthelmintic Activity ofHymenodictyon pachyantaStem Bark Extracts against Haemonchus Contortus

Olayemi¹,

Onakpa

Jegede³

2019

Folia Veterinaria

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The development of host resistance to anthelmintics and the increasing cost of commercial anthelmintics have encouraged the need for the in vitro anthelmintic evaluation of crude extract and fractions of Hymenodictyon pachyanta plant as alternative drugs against Haemonchus contortus. H. contortus is one of the most prevalent and highly pathogenic parasitic nematodes in small ruminant farming globally. H. pachyanta stem bark is a prospective plant used by the local and indigenous farmers of Nsukka, Enugu state, Nigeria. The stem bark of H. pachyanta were collected, dried, pulverized and extracted with 80 % methanol. The purpose of this study was to investigate the in vitro anthelmintic effects of these crude extract and fractions against H. contortus in sheep and goats. The two extracts (crude and fractions) of H. pachyanta were tested by the egg hatch assay (EHA) and the larval development inhibition assays (LDIA) and to compared the results with albendazole (as the positive control). The concentrations for the crude extract and albendazole used for this study were 0.78, 1.56, 3.125, 6.25 and 12.5 mg.ml−1. The results demonstrated that the crude extracts, fractions and albendazole all at the concentration doses of 12.5 mg.ml−1 produced 100 % inhibition of egg hatching and larval development. Statistically, there was no significant difference (P > 0.05) in the mean percentage inhibition of egg hatching and larval development inhibition of the crude extracts and fractions when compared with albendazole. However, a significant difference (P < 0.05) was observed with n-butanol fraction which inhibited 96.17 % of egg hatchability. All of the extracts and albendazole showed ovicidal and larvicidal effects and were able to induce over 50 % of the egg hatching and mortality of larvae at the concentration ranges of 0.78—12.5 mg.ml−1. The results obtained from our study suggest that H. pachyanta had ovicidal and larvicidal activity against H. contortus and that the bioactive plants compounds responsible for this effect could be attributed to the presence of tannins, alkaloids and the saponins contained in the crude extracts.

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Glycoside derivatives of scopoletin and β-sitosterol from Hymenodictyon floribundum

Cited by 6 publications

References 3 publications

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Taxonomic revision of the tribe Hymenodictyeae (Rubiaceae, Cinchonoideae)

Anthelmintic Activity ofHymenodictyon pachyantaStem Bark Extracts against Haemonchus Contortus

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