Glycoside- and acyclic nucleoside-based 6-cyclohexyl-4-aryl-2-oxonicotinonitrile: synthesis and antimicrobial evaluation

Synthesis, spectral characterization, crystal structure and computational investigation of 2-formyl-6-methoxy-3-carbethoxy quinoline as potential SARS-CoV inhibitor

“…Density functional theory (DFT) is one of the popular computational chemistry techniques to understand the molecular structure and its application, which is growing quickly. It is a successful and promising approach in theoretical estimations such as total energy of the system, atomic charge, electric and magnetic properties, vibrational frequencies, atomization energies, ionization energies, and reaction pathways [ [31] , [32] , [33] , [34] , [35] , [36] ].…”

Cyclization ofN‐benzyl cyanoacetamide: Novel synthesis and biological activity of pyrrole, pyrimidine, and pyran derivatives

“…Recently, our research interest directed to design and synthesis of biologically active heterocyclic systems from readily available reagents. [20,21] Herein, we hope to use a facile and direct approach to synthesize a novel series of heterocyclic systems (namely, pyridine, pyrrole, furan, thiazine, benzopyrane, and pyrazole) utilizing N-benzyl cyanoacetamide as simple synthetic synthon via addition reactions involving polarized π systems.…”

“…N ‐Benzyl cyanoacetamide (Figure ) contains multilateral reactive centers as β‐functional nitrile (CN), amide moiety (NHCO), and α‐CH acid, which are favorable reactive centers to react with numerous nucleophiles and electrophiles providing heterocyclic systems with different ring sizes that exhibit pharmaceuticals, antibacterial, anticoagulant, antifungacidal, antihistaminic agent, antileishhumanial agent, antimicrobial agent, herbicides, and dyes properties. Recently, our research interest directed to design and synthesis of biologically active heterocyclic systems from readily available reagents . Herein, we hope to use a facile and direct approach to synthesize a novel series of heterocyclic systems (namely, pyridine, pyrrole, furan, thiazine, benzopyrane, and pyrazole) utilizing N ‐benzyl cyanoacetamide as simple synthetic synthon via addition reactions involving polarized π systems.…”