Glycosidase-targeting small molecules for biological and therapeutic applications

Abstract

Recent advances made in the discovery of glycosidase-targeting small molecules for detection of glycosidases and treatment of glycosidase-associated diseases are discussed.

Real-time fluorescent monitoring of phase I xenobiotic-metabolizing enzymes

“…Such methodologies are indispensable for conducting comprehensive studies on the functional and structural aspects of these biologically significant glycans. 118,119…”

糖动态修饰与生物识别的原位化学探测

“…Guo课题组 [26] 开发 了β-Gal激活的近红外荧光探针及前药分子, 在自然衰 老和药物诱导衰老的小鼠模型中, 成功实现了衰老细 胞在体靶向清除. Shin课题组 [27] 于近期系统总结了靶 (c) 糖基光致变色探针所形成多价态 糖簇的受体靶向细胞内化及胞内光致变色行为调控 [18] (网络版彩图) Copyright@2017, Springer Nature (color online). .…”

Visual monitoring of biocatalytic processes using small molecular fluorescent probes: strategies-mechanisms-applications

“…This reaction is used for the diagnosis and detection of tumours as well as the detection of senescent cells. 7–9…”