Glycosaminoglycan-mimetic infernan grafted with poly(N-isopropylacrylamide): Toward a thermosensitive polysaccharide

Fillaudeau, Arnaud; Cuenot, Stéphane; Makshakova, Olga; Traboni, Serena; Sinquin, Corinne; Hennetier, Marie; Bedini, Emiliano; Perez, Serge; Colliec-Jouault, Sylvia; Zykwinska, Agata

doi:10.1016/j.carbpol.2023.121638

Cited by 2 publications

(1 citation statement)

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“…Particularly important among the thermosensitive polymer family is poly(Nalkyl acrylamide); it is also known as poly (N-isopropyl acrylamide) (PNIPAM). Preparing injectable hydrogels from polysaccharides based on PNIPAM has long been a research hotspot (Conzatti et al 2019;Fillaudeau et al 2024).…”

Section: Polymer Grafting Polysaccharidementioning

confidence: 99%

Thermosensitive injectable polysaccharide-based hydrogels: Gelation mechanisms, synthetic strategies, biomedical applications, and challenges

Sun,

Jiang

et al. 2024

BioRes

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In recent years, thermosensitive polysaccharide-based injectable hydrogels have gained increasing attention in biomedical applications, including wound healing, drug delivery, and cartilage repair. These hydrogels have favorable biocompatibility, biodegradability, and tunable physical and chemical properties. Thermosensitive polysaccharide-based injectable hydrogels are a class of intelligent soft matter material. They can undergo a reversible liquid-solid transition when exposed to temperature stimuli. Therefore, their precursor solutions can be accurately inserted into target sites with irregular geometries in a minimally invasive way and then transformed into gels in situ by the organism’s temperature stimulation to deliver biologically active molecules. This review summarizes the recent developments of thermosensitive injectable polysaccharide-based hydrogels. The focus is on the mechanism of sol-gel phase transition, as well as the design and preparation of thermosensitive polysaccharides and their applications in biomedical fields. In addition, the outlook of the challenges in biomedical applications is provided at the end of the paper.

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Section: Polymer Grafting Polysaccharidementioning

confidence: 99%