Glycosaminoglycan from Apostichopus japonicus induces immunomodulatory activity in cyclophosphamide-treated mice and in macrophages

Wang, Han; Xu, Lei; Yu, Mingming; Wang, Yuanhong; Jiang, Tianyue; Yang, Shuang; Lv, Zhihua

doi:10.1016/j.ijbiomac.2019.02.093

Cited by 34 publications

(35 citation statements)

References 46 publications

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“…It is usually active in the form of p50-p65 heterodimer and its inhibitory protein IκB [ 52 ]. NF-κB is composed of the dimeric proteins p65 and p50 of the Rel family that control genes for many biological processes, including innate and acquired immunity, inflammation, lymphatic organ production, B cell formation, and stress response [ 66 ]. The activation of NF-κB is related to the genes encoding pro-inflammatory cytokines, which participate in various biological processes such as immune response, inflammatory response, cell apoptosis, and tumorigenesis by regulating the expression of various genes [ 67 ].…”

Section: Discussionmentioning

confidence: 99%

“…A research study found that peptides from Solenocera crassicornis have immunomodulatory activity through the NF-κB signaling pathway, and have an important protective effect on immunosuppressed mouse models [ 68 ]. Glycosaminoglycan from Apostichopus japonicus [ 66 ] and Cordyceps sinensis [ 14 ] polysaccharides can balance the imbalance of cytokine secretion, regulate the NF-κB pathway, and repair Cy-induced intestinal immune dysfunction in mice. In this study, OP significantly enhanced the expression of p65 and IκBα phosphorylated proteins, suggesting that OP may play a protective role by activating the NF-κB pathway.…”

Section: Discussionmentioning

confidence: 99%

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Ameliorative Effects of Peptides Derived from Oyster (Crassostrea gigas) on Immunomodulatory Function and Gut Microbiota Structure in Cyclophosphamide-Treated Mice

et al. 2021

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The intestinal flora is recognized as a significant contributor to the immune system. In this research, the protective effects of oyster peptides on immune regulation and intestinal microbiota were investigated in mice treated with cyclophosphamide. The results showed that oyster peptides restored the indexes of thymus, spleen and liver, stimulated cytokines secretion and promoted the relative mRNA levels of Th1/Th2 cytokines (IL-2, IFN-γ, IL-4 and IL-10). The mRNA levels of Occludin, Claudin-1, ZO-1, and Mucin-2 were up-regulated, and the NF-κB signaling pathway was also activated after oyster peptides administration. Furthermore, oyster peptides treatment reduced the proportion of Firmicutes/Bacteroidetes, increased the relative abundance of Alistipes, Lactobacillus, Rikenell and the content of short-chain fatty acids, and reversed the composition of intestinal microflora similar to that of normal mice. In conclusion, oyster peptides effectively ameliorated cyclophosphamide-induced intestinal damage and modified gut microbiota structure in mice, and might be utilized as a beneficial ingredient in functional foods for immune regulation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Ameliorative Effects of Peptides Derived from Oyster (Crassostrea gigas) on Immunomodulatory Function and Gut Microbiota Structure in Cyclophosphamide-Treated Mice

et al. 2021

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“…Apparently, glycosaminoglycan stimulates the classical way of macrophage activation. In contrast, ethyl acetate solvent fraction (phenol content of about 20.4 mg/g) of A. japonicus at concentrations of 10, 50, and 100 µg/mL significantly inhibited the production of NO and PGE 2 by inhibiting iNOS and COX-2 at their protein and gene levels, as well as production and the gene transcription of proinflammatory cytokines IL-1β, TNF-α in LPS (1 µg/mL) stimulated RAW264.7 cells [147]. The responsible molecular signaling for these effects was found to be through suppression of the phosphorylation of MAPK molecules; ERK and p38 MAPK [148].…”

Section: Holothuroideamentioning

confidence: 90%

Different Macrophage Type Triggering as Target of the Action of Biologically Active Substances from Marine Invertebrates

Долматова

Dolmatov

2020

Marine Drugs

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Macrophages play a fundamental role in the immune system. Depending on the microenvironment stimuli, macrophages can acquire distinct phenotypes characterized with different sets of the markers of their functional activities. Polarization of macrophages towards M1 type (classical activation) is involved in inflammation and the related progression of diseases, while, in contrast, alternatively activated M2 macrophages are associated with the anti-inflammatory mechanisms. Reprogramming macrophages to switch their phenotypes could provide a new therapeutic strategy, and targeting the M1/M2 macrophage balance is a promising current trend in pharmacology. Marine invertebrates are a vast source of the variety of structurally diverse compounds with potent pharmacological activities. For years, a large number of studies concerning the immunomodulatory properties of the marine substances have been run with using some intracellular markers of immune stimulation or suppression irrespective of the possible application of marine compounds in reprogramming of macrophage activation, and only few reports clearly demonstrated the macrophage-polarizing activities of some marine compounds during the last decade. In this review, the data on the immunomodulating effects of the extracts and pure compounds of a variety of chemical structure from species of different classes of marine invertebrates are described with focus on their potential in shifting M1/M2 macrophage balance towards M1 or M2 phenotype.

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“…It is widely recognized that most bioactive properties of sea cucumbers derive from components extracted from their body wall. For example, in the case of S. japonicus total extracts exhibited anti-oxidant characteristics, and isolated molecules, such as unsaturated fatty acids and a fucosylated chondroitin sulfate glycosaminoglycan, were proven to exert α-glucosidase inhibitory, immunostimulatory, anti-coagulant, and hypolipidemic activities [180][181][182][183][184]. Collagen, which is the major component of the body wall of S. japonicus [185], has been studied for its potential as an additive and functional food ingredient that is capable of maintaining food quality thanks to its gelling properties [186,187].…”

Section: Echinodermatamentioning

confidence: 99%

Collective Locomotion of Human Cells, Wound Healing and Their Control by Extracts and Isolated Compounds from Marine Invertebrates

et al. 2020

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The collective migration of cells is a complex integrated process that represents a common theme joining morphogenesis, tissue regeneration, and tumor biology. It is known that a remarkable amount of secondary metabolites produced by aquatic invertebrates displays active pharmacological properties against a variety of diseases. The aim of this review is to pick up selected studies that report the extraction and identification of crude extracts or isolated compounds that exert a modulatory effect on collective cell locomotion and/or skin tissue reconstitution and recapitulate the molecular, biochemical, and/or physiological aspects, where available, which are associated to the substances under examination, grouping the producing species according to their taxonomic hierarchy. Taken all of the collected data into account, marine invertebrates emerge as a still poorly-exploited valuable resource of natural products that may significantly improve the process of skin regeneration and restrain tumor cell migration, as documented by in vitro and in vivo studies. Therefore, the identification of the most promising invertebrate-derived extracts/molecules for the utilization as new targets for biomedical translation merits further and more detailed investigations.

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Glycosaminoglycan from Apostichopus japonicus induces immunomodulatory activity in cyclophosphamide-treated mice and in macrophages

Cited by 34 publications

References 46 publications

Ameliorative Effects of Peptides Derived from Oyster (Crassostrea gigas) on Immunomodulatory Function and Gut Microbiota Structure in Cyclophosphamide-Treated Mice

Ameliorative Effects of Peptides Derived from Oyster (Crassostrea gigas) on Immunomodulatory Function and Gut Microbiota Structure in Cyclophosphamide-Treated Mice

Different Macrophage Type Triggering as Target of the Action of Biologically Active Substances from Marine Invertebrates

Collective Locomotion of Human Cells, Wound Healing and Their Control by Extracts and Isolated Compounds from Marine Invertebrates

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