Glycosaminoglycan and proteoglycan in skin aging

Lee, Dong Hun; Oh, Joo Youn; Chung, Jin Ho

doi:10.1016/j.jdermsci.2016.05.016

Cited by 153 publications

(147 citation statements)

References 49 publications

(137 reference statements)

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“…Proteoglycans are non-fibrillar components of the human dermis that interact with other matrix proteins such as the collagen network resulting in the formation of supramolecular structures able to increase tissue stiffness (Lee et al 2016) and to regulate important cell functions, such as proliferation, migration, protein synthesis or degradation (Maquart and Monboisse 2014). In general, we found that all skin types had similar amounts of proteoglycans as determined by histochemistry, but our analysis of specific molecules revealed some interesting differences for biglycan, which was more abundantly expressed by foot skin.…”

Section: Discussionmentioning

confidence: 99%

Characterization of the human ridged and non-ridged skin: a comprehensive histological, histochemical and immunohistochemical analysis

Vela-Romera

Carriel

Martín-Piedra

et al. 2018

Histochem Cell Biol

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The structure of the human skin is directly dependent on its location and the mechanical forces to which it is subjected. In the present work, we have performed a comprehensive analysis of the human ridged and non-ridged skin to identify the differences and similarities between both skin types. For this purpose, human skin samples were obtained from dorsal hand skin (DHS), palmar hand skin (PHS), dorsal foot skin (DFS) and plantar foot skin (PFS) from the same cadaveric donors. Histological, histochemical and semiquantitative and quantitative immunohistochemical analyses were carried out to evaluate the epidermis, dermis and basement membrane. Results show that the epithelial layer of ridged skin had larger cell number and size than non-ridged skin for most strata. Melanocytes and Langerhans cells were more abundant in non-ridged skin, whereas Merkel cells were preferentially found in ridged skin. The expression pattern of CK5/6 was slightly differed between non-ridged and ridged skin. Involucrin expression was slightly more intense in non-ridged skin than in ridged skin. Collagen was more abundant in foot skin dermis than in hand skin, and in ridged skin as compared to non-ridged skin. Elastic fibers were more abundant in DHS. Biglycan was more abundant in foot skin than in hand skin. No differences were found for blood and lymphatic vessels. The basement membrane laminin was preferentially found in foot skin. These results revealed important differences at the epithelial, dermal and basement membrane levels that could contribute to a better knowledge of the human skin histology.

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Section: Discussionmentioning

confidence: 99%

Characterization of the human ridged and non-ridged skin: a comprehensive histological, histochemical and immunohistochemical analysis

Vela-Romera

Carriel

Martín-Piedra

et al. 2018

Histochem Cell Biol

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“…Hyaluronic acid (HA) demonstrates excellent water retention properties and thus is an effective moisturizer providing increased skin firmness. Reportedly, HA content of the epidermis is reduced during the process of intrinsic aging . Reports have described skin color heterogeneity as an age‐related change.…”

Section: Introductionmentioning

confidence: 99%

Age‐related biophysical changes of the epidermal and dermal skin in Korean women

Cho

Cho²,

Kim³

et al. 2019

Skin Research and Technology

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Introduction The clinical characteristics of skin were investigated to study the inter‐relationship and changes in the biophysical properties of the epidermal and dermal layers associated with aging using noninvasive methods. Methods Our study included 100 healthy women aged between the early 20s and late 60s. Biophysical characteristics of skin such as color (brightness and spots), transparency, wrinkle on crow's feet, elasticity, hydration, sebum content, glossiness, and transepidermal water loss measured under controlled conditions. Results This study performed in a Korean population demonstrated that aging significantly affects human skin in terms of parameters such as wrinkles, skin color, elasticity, and epidermal hydration. Age‐related changes in skin hydration showed varying patterns between the epidermis and dermis. Skin color showed heterogeneous characteristics between the upper and lower epidermal layers associated with aging. Skin elasticity and wrinkles were observed to show and inversely proportional relationship in the early 40s. Conclusions We confirmed the significant influence of aging on the biophysical properties of skin and determined the distinct age‐related biophysical changes in the epidermal and dermal layers of skin using noninvasive method. This study indicates the need for further research to investigate the distinctive age‐related changes in characteristics of the epidermal and dermal layers of human skin.

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“…Wrinkles are a characteristic of aging skin, due in part to a reduction in the epidermal content of hyaluronic acid (HA; Lee, Oh, & Chung, ). Various bioactive agents have been used for skin rejuvenation, including exogenous HA, a biocompatible, relatively safe, and widely used material (Lee, Yang, et al, ).…”

Section: Introductionmentioning

confidence: 99%

Anti‐aging and hydration efficacy of a cross‐linked hyaluronic acid microstructure patch

Lee

Kim

Lee

et al. 2019

Dermatologic Therapy

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This study evaluated the safety and efficacy of biodegradable microstructure patches composed of cross‐linked hyaluronic acid (CLHA). A primary skin irritation test showed that the CLHA patches were not an irritant, whereas a clinical study showed that application of single CLHA patches significantly improved skin hydration at the periorbital region for 3 days and at the nasolabial fold for 6 days. Patch application also improved superficial wrinkles at the periorbital region for 3 days and at the nasolabial fold for 1 day. The absence of side effects indicated that application of these CLHA microstructure patches is both safe and convenient for moisturization and anti‐wrinkle effects.

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Glycosaminoglycan and proteoglycan in skin aging

Cited by 153 publications

References 49 publications

Characterization of the human ridged and non-ridged skin: a comprehensive histological, histochemical and immunohistochemical analysis

Characterization of the human ridged and non-ridged skin: a comprehensive histological, histochemical and immunohistochemical analysis

Age‐related biophysical changes of the epidermal and dermal skin in Korean women

Anti‐aging and hydration efficacy of a cross‐linked hyaluronic acid microstructure patch

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