Glycoprotein VI Gene Variants Affect Pregnancy Loss in Patients With Platelet Hyperaggregability

Sokol, Juraj; Škereňová, Mária; Biringer, Kamil; Šimurda, Tomáš; Kubisz, Peter; Staško, Ján

doi:10.1177/1076029618802358

Cited by 11 publications

(9 citation statements)

References 26 publications

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“…It is possible that some hypercoagulation conditions may lead to arterial thrombosis, which may result in uteroplacental thrombosis and obstetric complications. However, the exact mechanism is unknown (31). Thus, in our study, the expression of platelet miR-96 in young SPS women with recurrent fetal losses was found to be almost twice as high as that found in controls.…”

Section: Mir-96mentioning

confidence: 43%

MicroRNA and hyperaggregability of platelets in women with sticky platelet syndrome and pregnancy complications

Vadelová¹,

Škereňová²,

Ivankova³

et al. 2020

BLL

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AIMS: We aimed to characterize relationship between the expression profi les of platelet miR-96, miR-126 and miR-223 and platelet function examination in patients with sticky platelet syndrome (SPS) and in healthy controls. BACKGROUND: MicroRNAs (miRNA, miR) are a group of small and non-coding RNAs involved in many mechanisms as regulators of post-transcriptional protein expression in platelets. SPS is defi ned as platelet hyperaggregability after administration of low doses of adenosine diphosphate and/or epinephrine. Clear genetic abnormality of this syndrome is not known yet. METHODS: We examined 45 patients with SPS and 30 healthy volunteers. For functional platelet examination we used light transmission aggregometry, and qRT-PCR was used to determine the expression of the miRNAs. RESULTS: We observed no relationship of the platelet miRNA expression with functional platelet examination in the entire cohort of patients with SPS. However, in a group of patients with SPS and pregnancy complications, we found that the expression of platelet miR-96 (p = 0.009) was up-regulated. CONCLUSION: In spite of the multiple limitations of the study, it can be considered that the increased expression of platelet miR-96 found in a group of patients with SPS and pregnancy complications could be related to the hyperaggregability in these selected patients (Tab. 2, Ref. 31).

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Section: Mir-96mentioning

confidence: 43%

MicroRNA and hyperaggregability of platelets in women with sticky platelet syndrome and pregnancy complications

Vadelová¹,

Škereňová²,

Ivankova³

et al. 2020

BLL

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“…The authors recognized that the differences in genes associated with platelet receptors may alter the platelet reactivity and may change the efficacy of platelet inhibitors [ 22 ]. In another 12-year prospective study [ 23 ], the authors evaluated the variability of the GPVI gene in a group of patients with sticky platelet syndrome manifested as miscarriage. The authors determined the relationship between 15 selected SNPs of the GP6 gene in the studied syndrome compared to the control participants.…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms in GP6, PEAR1A, MRVI1, PIK3CG, JMJD1C, and SHH Genes in Patients with Unstable Angina

Rudzik

Dziedziejko

Rać

et al. 2020

IJERPH

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Introduction: Coronary artery disease (CAD) is a significant public health problem because it is one of the major causes of death worldwide. Several studies have investigated the associations between CAD and polymorphisms in genes connected with platelet aggregation and the risk of venous thromboembolism. Aim: In this study, we examined the associations between polymorphisms in GP6 (rs1671152), PEAR1A (rs12566888), MRVI1 (rs7940646), PIK3CG (rs342286), JMJD1C (rs10761741), SHH (rs2363910), and CAD in the form of unstable angina as well as selected clinical and biochemical parameters. The study enrolled 246 patients with diagnosed unstable angina and 189 healthy controls. Results: There were no significant differences in the distribution of the studied polymorphisms between the patients with unstable angina and the controls. In patients with the GP6 rs1671152 GG genotype, we observed increased BMI values and an increased frequency of type 2 diabetes diagnosis. Conclusions: The results of this study suggest a lack of association between GP6 (rs1671152), PEAR1A (rs12566888), MRVI1 (rs7940646), PIK3CG (rs342286), JMJD1C (rs10761741), SHH (rs2363910), and unstable angina. The results indicate an association between GP6 (rs1671152) and type 2 diabetes.

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“…Interestingly, the importance of the genetic diversity of the GP6 gene for platelet aggregation was highlighted by a genome-wide meta-analysis conducted by Johnson et al [ 20 ]. Moreover, a previous study identified several SNPs (rs1671153, rs1654419, and rs1613662) in patients with sticky platelet syndrome (SPS) [ 21 ] and a history of miscarriage (rs1671152, rs1654433, rs1613662, rs1654416, and rs2304167) [ 22 ]. In addition to their normal role in hemostasis, platelets can cause arterial thrombosis by blocking the collateral arteries after a collagen-rich atherosclerotic plaque has ruptured, resulting in heart attack and stroke [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Platelet-Specific Collagen Receptor Glycoprotein 6 Gene Variants, Selected Biomarkers, and Recurrent Pregnancy Loss in Korean Women

Ahn

Kim

et al. 2020

Genes

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This paper investigates whether glycoprotein 6 (GP6) gene polymorphisms are a risk factor for recurrent pregnancy loss (RPL) in Korean women. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism and real-time polymerase chain reaction amplification. We identified five polymorphisms in the GP6 gene: rs1654410 T>C, rs1671153 T>G, rs1654419 G>A, rs12610286 A>G, and rs1654431 G>A. GP6 rs1654410 CC was associated with decreased RPL risk (adjusted odds ratio = 0.292, 95% confidence interval = 0.105–0.815, p = 0.019), and recessive genotypes were also significantly associated with decreased RPL risk (adjusted odds ratio = 0.348, 95% confidence interval = 0.128−0.944, p = 0.038). GP6 rs1654419 GA was associated with decreased RPL risk (adjusted odds ratio = 0.607, 95% confidence interval = 0.375-0.982, p = 0.042), and dominant genotypes were significantly associated with decreased RPL risk (adjusted odds ratio = 0.563, 95% confidence interval = 0.358−0.885, p = 0.013). Altogether, the genotype frequencies of GP6 rs1654410 T>C and GP6 rs1654419 G>A were significantly different between RPL patients and control participants. Therefore, although GP6 polymorphisms may be useful as biomarkers of RPL, additional studies with heterogeneous cohorts are required to better understand the influence of GP6 and assess its performance as a biomarker.

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Glycoprotein VI Gene Variants Affect Pregnancy Loss in Patients With Platelet Hyperaggregability

Cited by 11 publications

References 26 publications

MicroRNA and hyperaggregability of platelets in women with sticky platelet syndrome and pregnancy complications

MicroRNA and hyperaggregability of platelets in women with sticky platelet syndrome and pregnancy complications

Polymorphisms in GP6, PEAR1A, MRVI1, PIK3CG, JMJD1C, and SHH Genes in Patients with Unstable Angina

Association between Platelet-Specific Collagen Receptor Glycoprotein 6 Gene Variants, Selected Biomarkers, and Recurrent Pregnancy Loss in Korean Women

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