Glycoprotein IIIa gene polymorphism and coronary artery disease

Aydınalp, Alp; Atar, İlyas; Ataç, Fatma Belgin; Yazıcı, Ayşe Canan; Cicek, Mutlu; Yılmaz, Mustafa; Ozgül, Aliseydi; Atar, Ash; Korkmaz, Mehmet Emin; Özin, Bülent; Müderrisoğlu, Haldun

doi:10.2143/ac.65.2.2047058

Cited by 3 publications

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“…A number of studies were not suitable for inclusion based on the following reasons: 12 studies were unavailable in English [10]–[21], three studies were familial-based [22]–[24], seven studies reported data that duplicated or overlapped with larger studies that were eligible for inclusion [25]–[31], 26 studies did not contain suitable outcome data [32]–[57], and in 11 studies all subjects had a coronary event and so there was no control population [58]–[68]. Following the addition of three studies identified in the secondary search [69]–[71], a total of 57 studies met the inclusion criteria for statistical analysis (Figure 1).…”

Section: Methodsmentioning

confidence: 99%

The PlA1/A2 Polymorphism of Glycoprotein IIIa as a Risk Factor for Myocardial Infarction: A Meta-Analysis

2014

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BackgroundThe PlA2 polymorphism of glycoprotein IIIa (GPIIIa) has been previously identified as being associated with myocardial infarction (MI), but whether this represents a true association is entirely unclear due to differences in findings from different studies. We performed a meta-analysis to evaluate whether this polymorphism is a risk factor for MI.MethodsElectronic databases (MEDLINE and EMBASE) were searched for all articles evaluating genetic polymorphisms of GPIIIa. For studies where acute coronary events were recorded in association with genetic analysis, pooled odds ratios (ORs) were calculated using fixed-effects and random-effects models. The primary outcome measure was MI, and a secondary analysis was also performed for acute coronary syndromes (ACS) more generally.Findings57 studies were eligible for statistical analysis and included 17,911 cases and 24,584 controls. Carriage of the PlA2 allele was significantly associated with MI (n = 40,692; OR 1.077, 95% CI 1.024–1.132; p = 0.004) but with significant publication bias (p = 0.040). The degree of association with MI increased with decreasing age of subjects (≤45 years old: n = 9,547; OR 1.205, 95% CI 1.067–1.360; p = 0.003) and with adjustment of data for conventional cardiovascular risk factors (n = 12,001; OR 1.240, 95% CI 1.117–1.376; p<0.001). There was a low probability of publication bias for these subgroup analyses (all p<0.05).ConclusionsThe presence of significant publication bias makes it unclear whether the association between carriage of the PlA2 allele and MI is true for the total population studied. However for younger subjects, the relative absence of conventional cardiovascular risk factors results in a significant association between carriage of the PlA2 allele and MI.

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Section: Methodsmentioning

confidence: 99%

The PlA1/A2 Polymorphism of Glycoprotein IIIa as a Risk Factor for Myocardial Infarction: A Meta-Analysis

2014

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“…tarafından bildirilenlerle uyumludur. [14] Adıgeçen çalışmada da GpIIIa polimorfizmi ile ne aterosklerotik plak yükü ne plak hassasiyeti arasında ilişki gösterilememiştir. Klopidogrele yanıt açısından bakıldığında araştırıcılar klopidogrel direncini saptamak için impedans agregometri yöntemini tercih etmişler, agregasyon inhibisyon düzeyleri ve direnç açısından da İTA-1a ve İTA-1B alel grupları arasında fark saptamamışlardır.…”

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Clopidogrel resistance and genetic factors

2013

Arch Turk Soc Cardiol

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Platelet glycoprotein IIIa Leu33Pro gene polymorphism and coronary artery disease: A meta-analysis of cohort studies

Verdoia¹,

Cassetti²,

Schaffer³

et al. 2014

Platelets

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Great interest has been focused in the last year on genetic predictors of cardiovascular risk. Glycoprotein IIb/IIIa (GP IIb/IIIa), fibrinogen receptor, is the final common pathway for aggregation and a key point for atherothrombosis. A single nucleotide polymorphism of IIIa subunit (Leu33Pro-PlA(1)/PlA(2) allele) has been suggested to increase aggregation and adhesion, however, contrasting reports have been reported so far on its effects on coronary artery disease (CAD). Aim of the current study was to perform a large meta-analysis including cohorts of patients undergoing coronary angiography in order to evaluate whether this polymorphism is associated with coronary artery disease. Literature archives (Pubmed, EMBASE, Cochrane) and main scientific sessions abstracts were scanned for data of consecutive cohorts of patients undergoing coronary angiography, where PlA genotype was assessed. Primary endpoint was the prevalence of CAD. Secondary endpoint was severity of CAD defined as prevalence of multivessel disease (≥2 vessels). Data from seven studies were extracted, including a final number of 6700 patients. Among them 1893 (28.3%) carried the PlA(2) polymorphism, 163 of them in homozygosis. Angiographically defined CAD was present in 3573 (74.3%) PlA(1)/PlA(1) patients and in 1430 (75.5%) PlA(2) carriers. PlA(2) polymorphism was not associated with an increased prevalence of coronary artery disease, (OR [95% CI] = 1.07 [0.95-1.21], p = 0.28, pheterogeneity = 0.39). Similar results were obtained for multivessel disease (OR [95% CI] = 1.07[0.95-1.20], p = 0.27, pheterogeneity = 0.12). Meta-regression analysis demonstrated a significant inverse relationship between the risk of CAD among the PlA(2) carriers and ageing (r = -0.044, (-0.09, -0.0008), p = 0.046). Present meta-analysis demonstrates that 33Leu → Pro substitution of GPIIIa does not influence the prevalence and extent of angiographically defined coronary artery disease in general population, although apparently playing a role among younger patients.

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Glycoprotein IIIa gene polymorphism and coronary artery disease

Abstract: The glycoprotein IIb/IIIa genotype was not shown to indicate the presence of atherosclerotic plaque. There was no correlation between the genotype and plaque vulnerability.

Cited by 3 publications

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The PlA1/A2 Polymorphism of Glycoprotein IIIa as a Risk Factor for Myocardial Infarction: A Meta-Analysis

The PlA1/A2 Polymorphism of Glycoprotein IIIa as a Risk Factor for Myocardial Infarction: A Meta-Analysis

Clopidogrel resistance and genetic factors

Platelet glycoprotein IIIa Leu33Pro gene polymorphism and coronary artery disease: A meta-analysis of cohort studies

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