Glycoprotein Biomarkers

Cell surface glycoproteomics: deciphering glycoproteins through a unique analytical capture approach

“…18,19 For instance, several glycoproteins have been routinely used as tumor markers, such as prostate-specic antigen (PSA), a-fetoprotein (AFP), cancer antigen 125 (CA125), and carcinoembryonic antigen. [20][21][22] More and more evidences show that abnormal glycosylation of CSP is closely related to various diseases, especially cancer, neurodegenerative diseases, inuenza a virus and inammation. 20,[23][24][25][26][27] Due to the importance of glycosylation changes in disease, identifying cell surface glycoprotein biomarkers and drug targets has become an attractive and widely pursued goal in biomedical industry and academia.…”

Glycoproteins as diagnostic and prognostic biomarkers for neurodegenerative diseases: A glycoproteomic approach

“…The discovery of glycoprotein biomarkers is highly dependent on the development of glycomic analysis methods. Glycomic technologies have developed rapidly in the past decades(Li et al, 2017;Yang & Wang, 2017). The glycomics lay behind genomics or proteomics generally due to the analytical challenges of elucidating glycan structures, glycosites, and glycosylation occupancy.…”