Glycopolypeptide Coordinated Nanovaccine: Fabrication, Characterization, and Antitumor Immune Response
Yingying Song,
Lin Teng,
Yanzheng Chen
et al.
Abstract:Cancer nanovaccine is a frontier
immunotherapy strategy, in which
the delivery carrier can protect antigen and adjuvant from degradation,
increase blood circulation half-life, and improve antigen permeability
and presentation, thus enhancing the security and potency of nanovaccine.
To address the barriers of antigen delivery, we design and fabricate
a kind of intracellular pH-sensitive glycopolypeptide coordinated
nanovaccine (OVA-HPGM-Mn) with ∼30% loading capacity of ovalbumin
(OVA). The nanovaccine OVA-HPGM… Show more
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