Glycophorin

Epand, Richard M.

doi:10.1002/0471203076.emm0221

Cited by 1 publication

(1 citation statement)

References 48 publications

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“…The authors suggest that the presence of a minor amount of cardiolipin, a strong inducer of negative SC, augments the efficiency of toxin pore formation because of the presence of a negative curvature region in the plane of the membrane around the toroidal pore. Recently, evidence has been reported pointing to the formation of toroidal-shaped pores by the pro-apoptotic proteins Bax [40,41] and tBid [42], though the data on the relationship between the bilayer SC and the membrane-permeabilizing potency of these proteins are rather diverse [41][42][43][44].…”

Section: Introductionmentioning

confidence: 99%

Effect of lipids with different spontaneous curvature on the channel activity of colicin E1: evidence in favor of a toroidal pore

Sobko¹,

Kotova²,

Antonenko³

et al. 2004

FEBS Letters

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The channel activity of colicin E1 was studied in planar lipid bilayers and liposomes. Colicin E1 pore-forming activity was found to depend on the curvature of the lipid bilayer, as judged by the effect on channel activity of curvaturemodulating agents. In particular, the colicin-induced transmembrane current was augmented by lysophosphatidylcholine and reduced by oleic acid, agents promoting positive and negative membrane curvature, respectively. The data obtained imply direct involvement of lipids in the formation of colicin E1-induced pore walls. It is inferred that the toroidal pore model previously validated for small antimicrobial peptides is applicable to colicin E1, a large protein that contains ten a-helices in its pore-forming domain.

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