Glycopeptide-Induced Neutropenia: Cross-Reactivity Between Vancomycin and Teicoplanin

Hsiao, Shu Hwa; Chang, Chia Ming; Tsai, Jui Chen; Lin, Chih-Hsien; Liao, Lina; Lin, Wen Liang; Wu, Ta Jen

doi:10.1345/aph.1h633

Cited by 17 publications

(13 citation statements)

References 20 publications

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“…Vancomycin was the only causative agent, except in 1 case where teicoplanin was attributed to the relapse of DRESS syndrome [17] . Cross-reactivity between vancomycin and teicoplanin has also been reported in other adverse events [8,11,12,16] . All patients survived after the immediate withdrawal of the glycopeptides and administration of intravenous corticosteroids.…”

Section: Discussionmentioning

confidence: 91%

“…Vancomycin may cause adverse skin reactions ranging from the 'red man syndrome', a histamine deliberation provoked by rapid infusion [6] , to thrombocytopenia [7] , agranulocytosis [8] , allergic exanthema [2] , anaphylaxis [6,9] , linear IgA bullous disease [10] , vasculitis [11] , erythema multiforme [12] and Stevens-Johnson syndrome/ toxic epidermal necrolysis [13,14] . In contrast, a vancomycin-induced DRESS syndrome is extremely rare, although a underreporting bias might exist.…”

Section: Discussionmentioning

confidence: 99%

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Vancomycin-Induced DRESS Syndrome in a Female Patient

Vauthey¹,

Uçkay²,

Abrassart³

et al. 2008

Pharmacology

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Background: DRESS syndrome (drug rash with eosinophilia and systemic symptoms) is a hypersensitivity reaction with skin rashes, eosinophilia, fever, lymph node enlargement and internal organ involvement. Case Report: A 60-year-old diabetic woman was hospitalized at the University Hospitals of Geneva for mid-leg amputation due to peripheral arterial occlusive disease. No drug allergy was reported. Because of a wound infection by methicillin-resistant Staphylococcus aureus, treatment with vancomycin (2 g/day) in continuous perfusion was initiated. Approximately 2 weeks later, she developed a toxidermia with fever, a progressive maculopapular skin rash, eosinophilia and acute renal insufficiency. The skin biopsy revealed a necrosis with lymphocytic and eosinophilic infiltrations, supporting the suspicion of DRESS syndrome. A cure was achieved by the withdrawal of vancomycin and the administration of methylprednisolone (1 g/day), antihistaminics and topical mometasone, without the introduction of other antibiotics. Conclusion: Vancomycin can be a cause of DRESS syndrome. A high index of suspicion is warranted in order not to miss this potentially lethal disease.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Vancomycin-Induced DRESS Syndrome in a Female Patient

Vauthey¹,

Uçkay²,

Abrassart³

et al. 2008

Pharmacology

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“…As vancomycin and teicoplanin share a similar glycopeptide structure, prior vancomycin intolerance may be the major precipitating factor for ADRs to subsequent teicoplanin therapy. Cross‐reactivity with regards to skin rash, fever, neutropenia and hypersensitivity syndrome has also been reported (2, 5–8).…”

Section: Discussionmentioning

confidence: 99%

“…Our hospital guidelines for MRSA identifies vancomycin as the first‐line choice for this indication and teicoplanin in cases of vancomycin intolerance. Some case reports have suggested the possibility of cross‐reactivity between the two antibiotics (2, 5–8), but few studies have examined the incidence of ADRs with sequential teicoplanin therapy following vancomycin. Our objective was to review data held in our drug‐use records to better define any cross‐reactivity between the two antibiotics.…”

Section: What Is Known and Objectivementioning

confidence: 99%

High risk of cross-reactivity between vancomycin and sequential teicoplanin therapy

Hsiao

Chou

Lin

et al. 2011

Journal of Clinical Pharmacy and Therapeutics

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“…A systematic analysis suggests that this phenomenon is likely to be duration rather than dose-related 4. A study in 2007 highlighted the case of a 57-year-old female with osteomyelitis who developed vancomycin-induced leucopenia 5. The regime was switched to teicoplanin.…”

Section: Discussionmentioning

confidence: 99%

Teicoplanin-induced leucopenia with immediate resolution after administration of G-CSF

2012

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Teicoplanin is used in a wide range of clinical settings, owing to its wide antiGram positive bacterial activity. Although it is generally well tolerated, adverse reactions such as fever and rash are well recognised. Haematological sequelae have been rarely reported. This case report describes the development of teicoplanin-induced leucopenia in a patient with infective endocarditis. A short course of lenograstim, a recombinant granulocyte colony-stimulating factor (G-CSF) reverted biochemical abnormalities. To the authors' best knowledge, this is the first documented example of implementation of G-CSF in such a clinical setting.

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Glycopeptide-Induced Neutropenia: Cross-Reactivity Between Vancomycin and Teicoplanin

Abstract: For all patients with vancomycin-induced neutropenia, possible cross-reactivity of teicoplanin should be monitored.

Cited by 17 publications

References 20 publications

Vancomycin-Induced DRESS Syndrome in a Female Patient

Vancomycin-Induced DRESS Syndrome in a Female Patient

High risk of cross-reactivity between vancomycin and sequential teicoplanin therapy

Teicoplanin-induced leucopenia with immediate resolution after administration of G-CSF

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