Glycopeptide antibiotics: evolving resistance, pharmacology and adverse event profile

Henson, Karl Evans; Levine, Miriam; Wong, Eunice Ann H

doi:10.1586/14787210.2015.1068118

Cited by 21 publications

(12 citation statements)

References 104 publications

(107 reference statements)

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“…It is interesting that the same dependence in antimicrobial activity was demonstrated by the reference positive control, vancomycin, which belongs to the group of glycopeptide antibiotics [ 14 ] and is structurally dissimilar to emericellipsin A. The same effect was demonstrated for peptaibol emerimicin IV, which was isolated from Emericellopsis minima and displays bactericidal activity towards methicillin-resistant S. aureus and vancomycin-resistant Enterococcus faecalis (Gram-positive species); Gram-negative E. coli was resistant [ 15 ].…”

Section: Resultsmentioning

confidence: 91%

A Novel Lipopeptaibol Emericellipsin A with Antimicrobial and Antitumor Activity Produced by the Extremophilic Fungus Emericellopsis alkalina

et al. 2018

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Soil fungi are known to contain a rich variety of defense metabolites that allow them to compete with other organisms (fungi, bacteria, nematodes, and insects) and help them occupy more preferential areas at the expense of effective antagonism. These compounds possess antibiotic activity towards a wide range of other microbes, particularly fungi that belong to different taxonomical units. These compounds include peptaibols, which are non-ribosomal synthesized polypeptides containing non-standard amino acid residues (alpha-aminoisobutyric acid mandatory) and some posttranslational modifications. We isolated a novel antibiotic peptide from the culture medium of Emericellopsis alkalina, an alkalophilic strain. This peptide, called emericellipsin A, exhibited a strong antifungal effect against the yeast Candida albicans, the mold fungus Aspergillus niger, and human pathogen clinical isolates. It also exhibited antimicrobial activity against some Gram-positive and Gram-negative bacteria. Additionally, emericellipsin A showed a significant cytotoxic effect and was highly active against Hep G2 and HeLa tumor cell lines. We used NMR spectroscopy to reveal that this peptaibol is nine amino acid residues long and contains non-standard amino acids. The mode of molecular action of emericellipsin A is most likely associated with its effects on the membranes of cells. Emericellipsin A is rather short peptaibol and could be useful for the development of antifungal, antibacterial, or anti-tumor remedies.

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Section: Resultsmentioning

confidence: 91%

A Novel Lipopeptaibol Emericellipsin A with Antimicrobial and Antitumor Activity Produced by the Extremophilic Fungus Emericellopsis alkalina

et al. 2018

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“…Contribution of CL CVVHDF to CL TOTAL was 51.2 ± 23.6%. Considering the elimination half‐life in normal kidney function is 70–100 h, the amount of teicoplanin eliminated in CVVHDF seems to be not dominant to remove the drug from circulation. However, the T 1/2 of 100.1 ± 42.7 hours was lower than that in patients with chronic renal insufficiency (157–567 h), suggesting that higher amounts of teicoplanin could be removed by CVVHDF.…”

Section: Discussionmentioning

confidence: 99%

High variability of teicoplanin concentration in patients with continuous venovenous hemodiafiltration

Lim

Lee

Kim

et al. 2019

Hemodialysis International

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Introduction: Continuous venovenous hemodiafiltration (CVVHDF) may alter teicoplanin pharmacokinetics and increase the risk of incorrect dosing. The objective of this prospective observational study was to assess the effect of CVVHDF on the pharmacokinetics of teicoplanin as maintenance therapy. Methods: Blood, urine, and dialysate samples were collected to measure teicoplanin levels. CVVHDF clearance (CLCVVHDF), total clearance (CLTOTAL), and volume of distribution (Vd) were calculated by simplex‐linear modeling. The influence of CVVHDF dose on teicoplanin pharmacokinetics was assessed. Findings: Ten samples from eight patients were studied. Creatinine clearance was 3.4 ± 5.1 ml/min/1.73 m2. Three patients were anuria. The dose for CVVHDF was 32.1 ± 7.0 mL/kg/h. Vd was 1.6 ± 0.7 L/kg. T1/2 was 100.1 ± 42.7 hours. CLTOTAL of teicoplanin was 11.9 ± 5.4 mL/min and CLCVVHDF was 5.8 ± 4.2 mL/min. Contribution of CLCVVHDF to CLTOTAL was 51.2% ± 23.6%. CLCVVHDF of individual teicoplanin varied widely. Large intra‐occasion differences were also observed. Dose of CLCVVHDF did not influence overall CLTOTAL, Vd, or half‐life. The proportion of CLTOTAL due to CLCVVHDF varied widely. It was high in some cases. Discussion: In patients receiving CVVHDF, there is great variability in teicoplanin pharmacokinetics which complicates empiric approach to dosing, suggesting the need for therapeutic drug monitoring.

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“…[18] So far,m ore than 4000 halometabolites have been discovered, [19] including commercially important antibiotics, such as chloramphenicol, [20] vancomycin, [21] and teicoplanin. [22] The presence of the tryptophan-halogenase-encoding gene (ADW94630.1) within the NRPS gene cluster was discovered in the genome sequence of Streptomyces toxytricini (NRRL 15443). [23] Aheterologous expression experiment indicated that the function of this gene was to induce chlorination at 6th positiono ft he tryptophan (Trp) indole group.…”

Section: Introductionmentioning

confidence: 99%

Isolation and Structure Determination of New Antibacterial Peptide Curacomycin Based on Genome Mining

et al. 2017

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An ew antibacterial cyclic peptide, named curacomycin (1), and its analogue dechlorocuracomycin (2)w ere isolated from Streptomyces curacoi (NBRC 12761 T )a nd Streptomyces noursei (NBRC 15452 T ), respectively,b yu sing genome mining. The chemical structures of these two peptides were determined by using ac ombination of MS (ESI) and NMR spectroscopy.T he structure of compound 1 was determinedt ob eac yclic peptide that consisted of six amino acids, including: valine (Val), leucine (Leu), isoleucine (Ile), ornithine (Orn), b-hydroxyasparagine (OHAsn), and 5chlorotryptophan (ClTrp). The NMR data of compound 2were very similar to that of compound 1,w hich indicated that the structure of compound 2 was ad echlorinated analogue of compound 1.Acomparison of the antimicrobiala ctivitieso ft hese two peptidesi ndicated that the presenceo f chlorine in compound 1 was critical for its antimicrobial activity.T he proposed biosynthetic gene clusters for compounds 1 and 2 were found in the genome data of S. curacoi and S. noursei,r espectively.T he functions of the biosynthetic genes werec onsidered by comparison of the two gene clusters.[a] I.

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Glycopeptide antibiotics: evolving resistance, pharmacology and adverse event profile

Cited by 21 publications

References 104 publications

A Novel Lipopeptaibol Emericellipsin A with Antimicrobial and Antitumor Activity Produced by the Extremophilic Fungus Emericellopsis alkalina

A Novel Lipopeptaibol Emericellipsin A with Antimicrobial and Antitumor Activity Produced by the Extremophilic Fungus Emericellopsis alkalina

High variability of teicoplanin concentration in patients with continuous venovenous hemodiafiltration

Isolation and Structure Determination of New Antibacterial Peptide Curacomycin Based on Genome Mining

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