Glycolic acid-g-chitosan-gold nanoflower nanocomposite scaffolds for drug delivery and tissue engineering

Kumari, Sangeeta; Singh, R. P.

doi:10.1016/j.ijbiomac.2011.10.014

Cited by 44 publications

(15 citation statements)

References 40 publications

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“…Organic–inorganic hybrid nanoflowers have been applied in many fields, including drug delivery [83], enzyme immobilization [84] and chemical testing probes [85,86]. Since it is difficult to achieve desired effects from the traditional hemostatic materials, especially in parenchymal organs with rich vascularity, to realize rapid hemostasis Yan et al [38] synthesized a biodegradable collagen sponge reinforced with chitosan/calcium pyrophosphate nanoflowers (CPNFs-Col) which was prepared by an improved one-pot-preparation method (Figure 5) [87].…”

Section: Cs-based Composite Hemostatic Materialsmentioning

confidence: 99%

Chitosan-Based Composite Materials for Prospective Hemostatic Applications

et al. 2018

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Effective hemostasis is vital to reduce the pain and mortality of patients, and the research and development of hemostatic materials are prerequisite for effective hemostasis. Chitosan (CS), with good biodegradability, biocompatibility and non-toxicity, has been widely applied in bio-medicine, the chemical industry, the food industry and cosmetics. The excellent hemostatic properties of CS have been extensively studied. As a result, chitosan-based composite hemostatic materials have been emerging. In this review, the hemostatic mechanism of chitosan is briefly discussed, and then the progress of research on chitosan-based composite hemostatic materials with multiple forms such as films, sponges, hydrogels, particles and fibers are introduced. Finally, future perspectives of chitosan-based composite hemostatic materials are given. The objective of this review is to provide a reference for further research and development of effective hemostatic materials.

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Section: Cs-based Composite Hemostatic Materialsmentioning

confidence: 99%

Chitosan-Based Composite Materials for Prospective Hemostatic Applications

et al. 2018

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“…Chitosan-graftpoly(glycolides) can be utilized in medicine, biology, for example, as separation membranes. Besides, they can be used as polymer matrices for the design of the nano-hybrid materials with the nano fillers based on the Pt/Fe 3 O 4 [178], Au/Fe 3 O 4 and Au [179,180] nanoparticles. These nanoparticles were confirmed to participate in the adsorption of encapsulated drugs molecules and in the adhesion of seeded stromal sells.…”

Section: Chitosan Modification With Mono-or Dicarboxylic Acidsmentioning

confidence: 99%

Functionalization of chitosan with carboxylic acids and derivatives of them: Synthesis issues and prospects of practical use: A review

Farion¹,

Бурдуковский²,

Kholkhoev³

et al. 2018

Express Polym. Lett.

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“…Their results demonstrated that exposure of L929 murine fibroblasts to the PET-AuNP scaffolds improved their cell integrity, decreased their production of reactive oxygen species and lowered bacterial adhesion to the PET; thus, their findings suggested AuNPs could enhance the biocompatibility of the PET mesh. Kumari and Singh (2012) synthesized gold nanoflowers (flower-like, three dimensional branched gold nanoparticles) and constructed glycolic acid-g-chitosan-gold nanoflower nanocomposite scaffold. The nanohybrid scaffold was stable at the medium pH and it was biocompatible through cell (SP2/0 mouse myeloma cell line) viability study.…”

Section: Nanoparticles and Cell Survivalmentioning

confidence: 99%

Functional enhancement of chitosan and nanoparticles in cell culture, tissue engineering, and pharmaceutical applications

Gao¹,

Lai²,

Leung³

2012

Front. Physio.

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As a biomaterial, chitosan has been widely used in tissue engineering, wound healing, drug delivery, and other biomedical applications. It can be formulated in a variety of forms, such as powder, film, sphere, gel, and fiber. These features make chitosan an almost ideal biomaterial in cell culture applications, and cell cultures arguably constitute the most practical way to evaluate biocompatibility and biotoxicity. The advantages of cell cultures are that they can be performed under totally controlled environments, allow high throughput functional screening, and are less costly, as compared to other assessment methods. Chitosan can also be modified into multilayer composite by combining with other polymers and moieties to alter the properties of chitosan for particular biomedical applications. This review briefly depicts and discusses applications of chitosan and nanoparticles in cell culture, in particular, the effects of chitosan and nanoparticles on cell adhesion, cell survival, and the underlying molecular mechanisms: both stimulatory and inhibitory influences are discussed. Our aim is to update the current status of how nanoparticles can be utilized to modify the properties of chitosan to advance the art of tissue engineering by using cell cultures.

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Glycolic acid-g-chitosan-gold nanoflower nanocomposite scaffolds for drug delivery and tissue engineering

Cited by 44 publications

References 40 publications

Chitosan-Based Composite Materials for Prospective Hemostatic Applications

Chitosan-Based Composite Materials for Prospective Hemostatic Applications

Functionalization of chitosan with carboxylic acids and derivatives of them: Synthesis issues and prospects of practical use: A review

Functional enhancement of chitosan and nanoparticles in cell culture, tissue engineering, and pharmaceutical applications

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