2006
DOI: 10.1016/s0065-2318(06)60005-x
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Glycol-Cleavage Oxidation

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Cited by 86 publications
(73 citation statements)
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“…1C). To investigate this further, we adducted RCs to a second model Ag, the glycoprotein OVA, by aldehyde treatment (2 or 20 mM FA or GA) or by NaIO 4 oxidation of the glycan (16,27,29). After adjuvantfree immunization of BALB/c mice, OVA-specific total IgG responses, pooled irrespective of the method of modification, correlated robustly with the moles of adducted RCs on OVA (r = 0.71, p = 0.036; Fig.…”
Section: Rc Adduction To Proteins By Common Aldehyde By-products Of Omentioning
confidence: 96%
“…1C). To investigate this further, we adducted RCs to a second model Ag, the glycoprotein OVA, by aldehyde treatment (2 or 20 mM FA or GA) or by NaIO 4 oxidation of the glycan (16,27,29). After adjuvantfree immunization of BALB/c mice, OVA-specific total IgG responses, pooled irrespective of the method of modification, correlated robustly with the moles of adducted RCs on OVA (r = 0.71, p = 0.036; Fig.…”
Section: Rc Adduction To Proteins By Common Aldehyde By-products Of Omentioning
confidence: 96%
“…depolymerization, and preserves both the pattern and degree of sulfation [98,99]. Periodate can selectively oxidize adjacent carbons bearing unsubstituted hydroxyl and /or amino groups [100], leading, in heparins, to the splitting of C(2)-C(3) bonds of un-sulfated uronic acids including the glucuronic acid, within the ATBR, essential for high anticoagulant activity [101]. Subsequent borohydride reduction leads to the "glycol-split" (gs) derivatives, also named reduced oxyheparins (ROHs), as shown in Fig.…”
Section: Glycol-split Heparins (Gs-heparins)mentioning
confidence: 99%
“…To analyze further the reactions catalyzed by the three isomerases, we examined the nature of the successively formed tetrose-4-Ps by taking advantage of the fact that reduction of erythrose-4-P, erythrulose-4-P, and 3-tetrulose-4-P with tritiated borohydride leads to specific incorporation of tritium on their C1, C2, and C3, respectively. Oxidation with periodate breaks down polyols according to well-known rules (20) predicting that the first carbon of tetritol-4-P will be converted to formaldehyde, the second one to formate, and the third and fourth ones to phosphoglycolaldehyde (see the expected patterns in Fig. S5).…”
Section: Identification Of the Intermediates With Tritiated Borohydrimentioning
confidence: 99%