Glycogen synthesis from glucose and fructose in hepatocytes from diabetic rats

Ciudad, Carlos J.; Carabaza, Assumpta; Guinovart, Joan J.

doi:10.1016/0003-9861(88)90049-5

Cited by 21 publications

(18 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous results have shown that liver and muscle glycogen synthesis is impaired in the diabetic state [2][3][4][5], information with which our results agree. Although the molecular basis are unknown, these defects have been attributed to either synthesis of GS, allosteric effects, and/ or GS translocation from a soluble to a particulate fraction [4,5,30,31].…”

Section: Discussionsupporting

confidence: 91%

“…Although the molecular basis are unknown, these defects have been attributed to either synthesis of GS, allosteric effects, and/ or GS translocation from a soluble to a particulate fraction [4,5,30,31]. The regulation of GS activity is known to be complex [1,32].…”

Section: Discussionmentioning

confidence: 99%

“…The metabolism of glycogen is intimately linked with insulin action and blood glucose homeostasis. Indeed, glycogen synthesis in rat hepatocytes is impaired in the diabetic state [3][4][5]. Diabetes is often accompanied by a variety of complications including retinopathy [6].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of Diabetes on Glycogen Metabolism in Rat Retina

et al. 2008

View full text Add to dashboard Cite

Glucose is the main fuel for energy metabolism in retina. The regulatory mechanisms that maintain glucose homeostasis in retina could include hormonal action. Retinopathy is one of the chemical manifestations of long-standing diabetes mellitus. In order to better understand the effect of hyperglycemia in retina, we studied glycogen content as well as glycogen synthase and phosphorylase activities in both normal and streptozotocin-induced diabetic rat retina and compared them with other tissues. Glycogen levels in normal rat retina are low (46 +/- 4.0 nmol glucosyl residues/mg protein). However, high specific activity of glycogen synthase was found in retina, indicating a substantial capacity for glycogen synthesis. In diabetic rats, glycogen synthase activity increased between 50% and 100% in retina, brain cortex and liver of diabetic rats, but only retina exhibited an increase in glycogen content. Although, total and phosphorylated glycogen synthase levels were similar in normal and diabetic retina, activation of glycogen synthase by glucose-6-P was remarkable increased. Glycogen phosphorylase activity decreased 50% in the liver of diabetic animals; it was not modified in the other tissues examined. We conclude that the increase in glycogen levels in diabetic retina was due to alterations in glycogen synthase regulation.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Diabetes on Glycogen Metabolism in Rat Retina

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Well controlled studies need to be conducted in human subjects to determine the effect of long-term physiologic doses of fructose (incorporated into mixed meals) on tissue glycogen storage. It would also be interesting to know whether glucose and fructose act synergistically on glycogen synthesis in human tissue as they have been reported to do in rat liver (15,71,74,107,108).…”

Section: Effect Of Fructose On Glycogen Synthesismentioning

confidence: 94%

Current Issues in Fructose Metabolism

Henry¹,

Crapo²,

Thorburn³

1991

Annu. Rev. Nutr.

102

View full text Add to dashboard Cite

The ingestion of fructose, particularly in refined form, has significantly increased in the North American diet over the last two decades. The unique way in which fructose is metabolized has given rise to much research examining whether fructose is advantageous in appetite control, exercise endurance, and disease states such as diabetes. Overall, there is very little evidence that modest amounts of fructose have detrimental effects on carbohydrate and lipid metabolism in nondiabetic or NIDDM subjects or that its use is particularly advantageous compared to that of other sugars. However, fructose can cause insulin and triglyceride levels to rise dramatically, and hence be potentially harmful, in a subgroup of NIDDM subjects who have concomitant pronounced hypertriglyceridemia. Large doses of fructose should also be avoided by subjects with gout because of the hyperuricemia which may result. No evidence exists that fructose has any clear advantages over glucose in regard to exercise endurance. Similarly there is no conclusive evidence that physiologic amounts of dietary fructose exacerbate copper deficiency or aid in weight control.

show abstract

“…Fructose has been shown to increase hepatic glucose phosphorylation via activation of glucokinase 101; and inhibit glycogenolysis via suppression of phosphorylase 102. Increased hepatic glycogen synthesis via activation of glycogen synthase produced by fructose administration in diabetic and non-diabetic rats has been reported 101, 103. Evidence has also implicated the complementary and synergistic role of fructose and glucose on key enzymes involved in the metabolism of glucose and glycogen in the liver 104, 105.…”

Section: Potential Effect Of Honey In the Livermentioning

confidence: 99%

Honey - A Novel Antidiabetic Agent

Erejuwa

Sulaiman²,

Wahab³

2012

Int. J. Biol. Sci.

126

120

View full text Add to dashboard Cite

Diabetes mellitus remains a burden worldwide in spite of the availability of numerous antidiabetic drugs. Honey is a natural substance produced by bees from nectar. Several evidence-based health benefits have been ascribed to honey in the recent years. In this review article, we highlight findings which demonstrate the beneficial or potential effects of honey in the gastrointestinal tract (GIT), on the gut microbiota, in the liver, in the pancreas and how these effects could improve glycemic control and metabolic derangements. In healthy subjects or patients with impaired glucose tolerance or diabetes mellitus, various studies revealed that honey reduced blood glucose or was more tolerable than most common sugars or sweeteners. Pre-clinical studies provided more convincing evidence in support of honey as a potential antidiabetic agent than clinical studies did. The not-too-impressive clinical data could mainly be attributed to poor study designs or due to the fact that the clinical studies were preliminary. Based on the key constituents of honey, the possible mechanisms of action of antidiabetic effect of honey are proposed. The paper also highlights the potential impacts and future perspectives on the use of honey as an antidiabetic agent. It makes recommendations for further clinical studies on the potential antidiabetic effect of honey. This review provides insight on the potential use of honey, especially as a complementary agent, in the management of diabetes mellitus. Hence, it is very important to have well-designed, randomized controlled clinical trials that investigate the reproducibility (or otherwise) of these experimental data in diabetic human subjects.

show abstract

Glycogen synthesis from glucose and fructose in hepatocytes from diabetic rats

Cited by 21 publications

References 40 publications

Effect of Diabetes on Glycogen Metabolism in Rat Retina

Effect of Diabetes on Glycogen Metabolism in Rat Retina

Current Issues in Fructose Metabolism

Honey - A Novel Antidiabetic Agent

Contact Info

Product

Resources

About