Glycogen storage disease of the muscles

The structure of cardiac glycogen in healthy mice

“…It is unknown whether this increased quantity is of the healthy ␣ and ␤-particle sort, or whether there is a much larger particle, or a lack of ␣-particles with an excess of ␤-particles. Glycogen storage diseases (GSD) that are unique to the heart, such as types I, III and IV [33], result in cardiac glycogen of distinctive clinical and chemical manifestations [46]. These distinct differences may involve an inability to form the healthy ␣-particles, due to a different structure of the ␤-particles.…”

Skeletal Muscle Glycogenosis in Identical Twins

“…Thus these patients differ from the cases in which serum lactic acid and pyruvate are not increased (Pearson et al, 1961 ;Schmid and Hammaker, 1961 ; di Sant'Agnese, Andersen, and Metcalf, 1962), although they more closely resemble other recorded cases showing a slight increase (Schmid and Mahler, 1959 ;Mellick, Mahler, and Hughes, 1962). Our own experience suggests that a slight rise in lactic acid in the serum indicates a glycogen myopathy.…”

Martha Wollstein of Babies Hospital in New York City (1868–1939)—The First North American Pediatric Pathologist

“…49,50 Not surprisingly, Andersen made use of some of Wollstein’s autopsy specimens for her cardiac and glycogen storage disease research. 51 Therefore, Wollstein’s successor at Babies Hospital also became an accomplished female pediatric pathologist clinician–scientist. In fact, it is interesting to note that all of the Babies Hospital pathologists for over 50 years were women and that 3 are historically important; Dr Andersen actually became the Chief of Pathology at Columbia—Presbyterian Hospital in 1958.…”