Glycodynamers: Fluorescent Dynamic Analogues of Polysaccharides

Abstract

Eingriffe in die Konstitution: Dynamische Glycopolymere mit einer Poly(acylhydrazon)‐Hauptkette und Oligosaccharid‐Seitengruppen haben laut Kryo‐TEM‐ und Kleinwinkelneutronenstreuexperimenten eine Bürstenstruktur (siehe Bild). Die Fluoreszenz‐Emissionswellenlängen lassen sich durch Austausch oder Einbau von Komponenten einstellen, die die Polymerkonstitution verändern.

Room Temperature Dynamic Polymers Based on Diels–Alder Chemistry

“…[3] Dynamers that display rapid exchange at room or physiological temperatures are of particular interest because they can find applications as biopolymers or drug-delivery systems. [4] We recently reported a system based on Diels-Alder chemistry that already displays dynamicity at room temperature. [5] It involved fulvenes as the dienes and dicyanofumarates or tricyanoethylenecarboxylates as the dienophiles, and may allow the generation of room-temperature dynamers.…”

Dynamic Covalent Chemistry: A Facile Room‐Temperature, Reversible, Diels–Alder Reaction between Anthracene Derivatives and N‐Phenyltriazolinedione

“…[1] It represents the covalent domain of constitutional dynamic chemistry (CDC), which also encompasses dynamic supramolecular/noncovalent entities. [2][3][4][5][6][7][8][9][10] DCC provides new insights into the field of drug discovery [12][13] and the development of smart materials, such as dynamic polymers (dynamers). Transesterification, [2a-h] transallylesterification, [2i] transamidation, [3a-c] aldol exchange, [4] acetal exchange, [5] hydrazone exchange, [6] transimination, [7] processes involving disulfide exchange, [8] metal-ligand exchange, [9] and Diels-Alder (DA) reactions, [10][11] are representative examples of reactions employed to generate dynamic libraries in this expanding field of DCC.…”

“…Transesterification, [2a-h] transallylesterification, [2i] transamidation, [3a-c] aldol exchange, [4] acetal exchange, [5] hydrazone exchange, [6] transimination, [7] processes involving disulfide exchange, [8] metal-ligand exchange, [9] and Diels-Alder (DA) reactions, [10][11] are representative examples of reactions employed to generate dynamic libraries in this expanding field of DCC. [2][3][4][5][6][7][8][9][10] DCC provides new insights into the field of drug discovery [12][13] and the development of smart materials, such as dynamic polymers (dynamers). [14][15] In this context, dynamic DA reactions are particularly intriguing, owing to the fact that they are not only reversible, but also self-contained processes (i.e., all of the atoms present in the starting materials are present in the products).…”

Self‐Healing of Chemical Gels Cross‐Linked by Diarylbibenzofuranone‐Based Trigger‐Free Dynamic Covalent Bonds at Room Temperature

“…18 Reversible Diels–Alder units have been investigated for thermally healable materials 14. 19, 20 Lehn and co‐workers reported new Diels–Alder units that display reversible structural transformation at room temperature in the absence of external stimuli, although no mechanical data on these materials was reported 21. 22…”