Glyco‐Functionalized Liposomes

Weingart, Jacob; Vabbilisetty, Pratima; Sun, Xue‐Long

doi:10.1002/9781118860212.ch8

Cited by 6 publications

(20 citation statements)

References 88 publications

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“…Liposomes are biocompati-ble, biodegradable, non-toxic, and non-immunogenic. Moreover, liposomes have both lipophilic and aqueous environments making them useful for delivering hydrophobic, amphipathic, and hydrophilic drugs [18,35,36] Liposomal surface functionalization unlocks the enormous potential in the application of liposomes. Various biomolecules have been conjugated to liposome surfaces for a variety of biomedical applications.…”

Section: Carbohydrate Functionalized Nano-carriers For Cancer Targeting and Ther-apymentioning

confidence: 99%

“…Several strategies have been developed and used for functionalizing the surface of liposomes with carbohydrate ligands. The two most commonly used techniques are the direct liposome formulation method and the post functionalization approach [35]. The direct liposome formulation approach involves the synthesis of the glycolipid ligand followed by the preparation of liposomes using other principal lipids.…”

Section: Carbohydrate Functionalized Nano-carriers For Cancer Targeting and Ther-apymentioning

confidence: 99%

“…In addition, the drug release from liposomes was studied using the dialysis method and the percent cumulative drug release after 24 h was low (around 34.8%). The major limitation of the direct formulation method is that some of the carbohydrate targeting ligands may face the interior aqueous compartment of the formed liposomes, and become unavailable for interaction with their receptors [35,39,44]. To solve this issue, several research groups have opted for the post functionalization approach.…”

Section: Carbohydrate Functionalized Nano-carriers For Cancer Targeting and Ther-apymentioning

confidence: 99%

“…For these reasons, the characterization of liposomes has focused on methods that address surface morphology. These methods include dynamic light scattering (DLS), transmission electron microscopy (TEM), high-performance liquid chromatography (HPLC), and enzymatic methods [35].…”

Section: Carbohydrate Functionalized Nano-carriers For Cancer Targeting and Ther-apymentioning

confidence: 99%

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Carbohydrate-functionalized Liposomes in Cancer Therapy

AlSawaftah

Abusamra

Husseini

2021

CCTR

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: Existing cancer treatments are often accompanied by adverse side effects that can greatly reduce the quality of life of cancer patients; this sets the platform to the development and application of nanocarrier-based platforms for the delivery of anticancer drugs. Among these nanocarriers, liposomes have demonstrated excellent potential in drug delivery applications. Furthermore, the overexpression of certain receptors on cancer cells has led to the development of active targeting approaches where liposome surfaces are decorated with ligands against these receptors. Given the central role that sugars play in cancer biology, more and more researchers are integrating “glycoscience” into their anticancer therapeutic designs. Carbohydrate functionalized liposomes present an attractive drug delivery system due to their biocompatibility, biodegradability, low toxicity, and specific cell targeting ability. This review presents an overview of the preparation methods, characterization, evaluation, and applications of carbohydrate functionalized liposomes in cancer therapy.

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Section: Carbohydrate Functionalized Nano-carriers For Cancer Targeting and Ther-apymentioning

confidence: 99%

Section: Carbohydrate Functionalized Nano-carriers For Cancer Targeting and Ther-apymentioning

confidence: 99%

Section: Carbohydrate Functionalized Nano-carriers For Cancer Targeting and Ther-apymentioning

confidence: 99%

Section: Carbohydrate Functionalized Nano-carriers For Cancer Targeting and Ther-apymentioning

confidence: 99%

See 2 more Smart Citations

Carbohydrate-functionalized Liposomes in Cancer Therapy

AlSawaftah

Abusamra

Husseini

2021

CCTR

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“…As with the aforementioned NCs, liposomes have been functionalized over time in order to achieve desirable properties, like stability, cell penetration, and so on [ 200 , 201 , 202 , 203 ]. PEGylated liposomes as promising particles to achieve long-circulating or as effective drug carriers have been widely synthesized [ 204 , 205 , 206 , 207 ].…”

Section: Types Of Nanocarriersmentioning

confidence: 99%

Surface Modified Multifunctional and Stimuli Responsive Nanoparticles for Drug Targeting: Current Status and Uses

Sıafaka

Okur

Karavas

et al. 2016

IJMS

156

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Nanocarriers, due to their unique features, are of increased interest among researchers working with pharmaceutical formulations. Polymeric nanoparticles and nanocapsules, involving non-toxic biodegradable polymers, liposomes, solid lipid nanoparticles, and inorganic–organic nanomaterials, are among the most used carriers for drugs for a broad spectrum of targeted diseases. In fact, oral, injectable, transdermal-dermal and ocular formulations mainly consist of the aforementioned nanomaterials demonstrating promising characteristics such as long circulation, specific targeting, high drug loading capacity, enhanced intracellular penetration, and so on. Over the last decade, huge advances in the development of novel, safer and less toxic nanocarriers with amended properties have been made. In addition, multifunctional nanocarriers combining chemical substances, vitamins and peptides via coupling chemistry, inorganic particles coated by biocompatible materials seem to play a key role considering that functionalization can enhance characteristics such as biocompatibility, targetability, environmental friendliness, and intracellular penetration while also have limited side effects. This review aims to summarize the “state of the art” of drug delivery carriers in nanosize, paying attention to their surface functionalization with ligands and other small or polymeric compounds so as to upgrade active and passive targeting, different release patterns as well as cell targeting and stimuli responsibility. Lastly, future aspects and potential uses of nanoparticulated drug systems are outlined.

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Functionalized liposomes: a nanovesicular system

Misra

Pathak

2022

Systems of Nanovesicular Drug Delivery

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Glyco‐Functionalized Liposomes

Cited by 6 publications

References 88 publications

Carbohydrate-functionalized Liposomes in Cancer Therapy

Carbohydrate-functionalized Liposomes in Cancer Therapy

Surface Modified Multifunctional and Stimuli Responsive Nanoparticles for Drug Targeting: Current Status and Uses

Functionalized liposomes: a nanovesicular system

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