Glycine site N-methyl-D-aspartate receptor antagonist 7-CTKA produces rapid antidepressant-like effects in male rats

7-Chlorokynurenic acid (7-CTKA) produces rapid antidepressant-like effects: through regulating hippocampal microRNA expressions involved in TrkB-ERK/Akt signaling pathways in mice exposed to chronic unpredictable mild stress

“…In the present study, we observed that 7-CTKA produced a rapid antidepressant action in CUMS mice 1 day after 7-CTKA treatment, which could be consistent with a previous report (Zhu et al 2013), and investigated the effect of CUMS on hippocampal miRNA levels in ICR mice. Moreover, we probed the influence of four different acute treatments, vehicle + 7-CTKA, K252a + 7-CTKA, U0126 + 7-CTKA, and LY294002 + 7-CTKA, on miRNA expressions in the hippocampus of those which had undergone CUMS.…”

“…7-Chlorokynurenic acid (7-CTKA), a glycine recognition site NMDA receptor antagonist, has been shown to have neuroprotective and antinociceptive effects (Chen et al 1993). Furthermore, the results not only supported the hypothesis that 7-CTKA had fast-acting antidepressant effects by activating the mammalian target of rapamycin (mTOR) in rat hippocampus, but suggested that 7-CTKA at an effective antidepressant dose did not have rewarding property compared with katamine (Zhu et al 2013).…”

The Prodrug 4-Chlorokynurenine Causes Ketamine-Like Antidepressant Effects, but Not Side Effects, by NMDA/GlycineB-Site Inhibition

“…However, the involvement of the glycine B site of the NMDA receptor in the antidepressant effects of GLYX-13 has not been directly demonstrated so far. Maj et al (1994) described antidepressant-like effects following repeated, but not single, administration of 7-Cl-KYNA (20 mg/kg) in the FST, and acute antidepressant-like effects were seen after a single injection of low doses of 7-Cl-KYNA in rats (Zhu et al, 2013;Liu et al, 2015). However, the latter findings were not replicated in our experiments.…”

Macranthol promotes hippocampal neuronal proliferation in mice via BDNF–TrkB–PI3K/Akt signaling pathway

“…Our results were in accordance with previous studies (Zhu et al, 2013, Yi et al, 2014b, indicating that CUMS treatment led to susceptibility and anhedonia in mice. Administration of 40 mg/kg macranthol for 21 days reversed the behavioral deficits in mice, which was consistent with our previous study .…”