Glycine preserves function and decreases necrosis in skeletal muscle undergoing ischemia and reperfusion injury

The role of glycine in regulated cell death

“…Glycine supplementation had beneficial cardiac effects in a burn model [241]. Infusion of glycine at the end of 6 hours of skeletal muscle ischemia and then during the first hour of reperfusion decreased necrosis and increased metabolic and functional recovery [242]. Glycine suppression of reactive oxygen species production by neutrophils [165] may have played a major role in this skeletal muscle effect [243].…”

In vitro apoptotic activity of 2,2-diphenyl-1,3,2-oxazaborolidin-5-ones in L5178Y cells

“…Apoptotic pathways might be significantly altered in cancer cells with respect to untransformed cells, and these differences may represent a therapeutic window that can be explored for the development of new antineoplastic drugs. There are reports in the literature of the cytoprotector effects of glycine and its nitrogen derivatives, evaluated in different models of damage related to the accumulation of free radicals (Tripathi et al, 2000;Yan-Jun et al, 2000;Ascher et al, 2001;Jacob et al, 2003;Tanonaka et al, 2002). Substantial data supports the existence of a glycine receptor in the membrane of the cell, whose activation reduces the release of reactive oxygen species (ROS), thus protecting the cell from damage by the latter (Yan-Jun et al, 2000;Jacob et al, 2003).…”

Effect of glycine on the release of reactive oxygen species in human neutrophils

“…The protection granted by Gly was observed in diverse organs including liver [9,12], intestine [13,1], kidney [4], heart [14] and skeletal muscle [2] and different cells affected by hypoxic injury like renal tubular cells [15], myocytes [14], and hepatocytes [16]. The subcellular mechanism underlying the cytoprotection produced by Gly could be the stabilization of the plasmatic membrane [3], the blockade of the opening of permeability transition pores in the mitochondrial inner membrane, or the inhibition of the calcium accumulation in the cells.…”

“…Recent studies demonstrated that the increase of extracellular glycine (Gly) concentration prevents or mitigates a variety of pathological dysfunctional inflammatory responses associated with processes like ischemia and reperfusion [1][2][3][4], hemorrhagic shock [5], endotoxic shock [6,7] or transplantation [8,9].…”