Glycerol Salicylate-based Pulp-Capping Material Containing Portland Cement

Abstract

The purpose of this study was to evaluate the water sorption, solubility, pH and ability to diffuse into dentin of a glycerol salicylate-based, pulp-capping cement in comparison to a conventional calcium hydroxide-based pulp capping material (Hydcal). An experimental cement was developed containing 60% glycerol salicylate resin, 10% methyl salicylate, 25% calcium hydroxide and 5% Portland cement. Water sorption and solubility were determined based on mass changes in the samples before and after the immersion in distilled water for 7 days. Material discs were stored in distilled water for 24 h, 7 days and 28 days, and a digital pHmeter was used to measure the pH of water. The cement's ability to diffuse into bovine dentin was assessed by Raman spectroscopy. The glycerol salicylate-based cement presented higher water sorption and lower solubility than Hydcal. The pH of water used to store the samples increased for both cements, reaching 12.59 ± 0.06 and 12.54 ± 0.05 after 7 days, for Hydcal and glycerol salicylate-based cements, respectively. Both cements were able to turn alkaline the medium at 24 h and sustain its alkalinity after 28 days. Hydcal exhibited an intense diffusion into dentin up to 40 µm deep, and the glycerol salicylate-based cement penetrated 20 µm. The experimental glycerol salicylate-based cement presents good sorption, solubility, ability to alkalize the surrounding tissues and diffusion into dentin to be used as pulp capping material.

Effect of an Experimental Direct Pulp-capping Material on the Properties and Osteogenic Differentiation of Human Dental Pulp Stem Cells

“…Many studies have focused on PC, which is compositionally similar to MTA, but less expensive. Several studies have suggested that PC is biocompatible and can be used as a safe pulp-capping material, and many PC-based materials have been investigated to meet clinical requirements 13 14 .…”

Effect of preheating on cytotoxicity and physicochemical properties of light-cured calcium-based cements.

“…However, when this loss of mass is very significant, an empty space remains between the mineralized tissue and the restorative material. Thus, there is a need to achieve a balance between being soluble enough to have a therapeutic effect on the pulp tissue and not compromising the restorative procedure mechanically 40 .…”

Untitled

“…stimulate pulp repair, dentin bridge formation, and its antimicrobial activity due from the high pH generated by the material [2][3][4][5][6] . However, calcium hydroxide-based cement shows several limitations, including rapid degradation, which is often incompatible with the repair time, the formation of tunnel defects in the dentin bridge, intense caustic, and inadequate sealing 7,8 .…”