Glycerol fructose combined with vitamin B6 is beneficial to postoperative recovery of patients with cerebral aneurysm

Abstract

The aim of the present study is to investigate whether glycerol fructose combined with vitamin B6 is beneficial to the postoperative recovery of patients with cerebral aneurysm (CA). A total of 134 patients receiving embolization of CA in the Central Hospital of Wuhan between February, 2013 and June, 2015 and were divided into observation and control groups according to the random number table method, with 67 cases in each group. The control was given vitamin B6 routine treatment, while the observation group received glycerol fructose on the basis of treatment in the control group. The incidence rate of postoperative complications after treatment, Glasgow coma scale (GCS) score, Barthel index score, and neurological fatigue index (NFI) score were compared between the two groups. After treatment, the GCS, Barthel index and NFI scores of patients in the observation were better than those in the control group (p<0.05), and the Barthel index score in the observation group was significantly higher than that in the control group (p<0.01). The mean flow velocity of middle cerebral artery (MCA) in the observation group after treatment was significantly different from that in the control group (p<0.05). As for complications, the incidence rates of postoperative cerebral vasospasm (1.49%), cerebral ischemia (1.49%), hematoma at puncture site (2.98%) and aneurysm rupture and hemorrhage (4.47%) in the observation group were lower than those of cerebral vasospasm (8.95%), cerebral ischemia (7.46%), hematoma at puncture site (8.95%) and aneurysm rupture and hemorrhage (10.44%) in the control group, and the differences were statistically significant (p<0.05). In conclusion, glycerol fructose combined with vitamin B6 can reduce the incidence rate of postoperative complications and improve patients self-care ability and quality of life. Therefore, it is beneficial to postoperative recovery and it is worthy of clinical application.

Blood metabolomic profiling predicts postoperative gastrointestinal function of colorectal surgical patients under the guidance of goal-directed fluid therapy

“…Pyruvate affects energy production, which is easily influenced by fluid management, and is reflected in phosphohydroxypyruvic acid levels [ 18 ]. Vitamin B6 is helpful for the postoperative recovery of patients with cerebral aneurysm [ 19 ], and its importance in patients with colorectal cancer suggests that this compound may be beneficial in general postoperative recovery, i.e., for patients undergoing different types of surgeries. Additionally, the tricarboxylic acid (TCA) cycle is activated in energy supplement-related processes, which can be affected by liquid management [ 20 ].…”

Blood Metabolomic Profiling Predicts Postoperative Gastrointestinal Function Of Colorectal Surgical Patients Under The Guidance Of Goal-Directed Fluid Therapy

“…[18] Pyruvate affects energy production, which is easily in uenced by uid management, and is re ected in phosphohydroxypyruvic acid levels. [19] Vitamin B6 is helpful for the postoperative recovery of patients with cerebral aneurysm, [20] and its importance in patients with colorectal cancer suggests that this compound may be bene cial in general postoperative recovery, i.e., for patients undergoing different types of surgeries. Additionally, the tricarboxylic acid (TCA) cycle is activated in energy supplementrelated processes, which can be affected by liquid management.…”