Glycerol as Eco‐Efficient Solvent for Organic Transformations

Cu(I)-catalyzed azide−alkyne cycloaddition (CuAAC) is a modular and bioorthogonal approach that is being adopted for the efficient synthesis of organic and bioorganic compounds. It leads to the selective formation of 1,4-disubstituted 1,2,3-triazole units connecting readily accessible building blocks via a stable and biocompatible linkage. The vast array of the bioconjugation applications of click chemistry has been attributed to its fast reaction kinetics, quantitative yields, minimal byproducts, and high chemospecificity and regioselectivity. These combined advantages make click reactions quite suitable for the lead identification and the development of pharmaceutical agents in the fields of medicinal chemistry and drug discovery. In this review, we have outlined the key aspects, the mechanistic details and merits and demerits of the click reaction. In addition, we have also discussed the recent pharmaceutical applications of click chemistry, ranging from the development of anticancer, antibacterial, and antiviral agents to that of biomedical imaging agents and clinical therapeutics.

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An Overview of Recent Advances in Biomedical Applications of Click Chemistry

Kaur

2021

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Glycerol as Eco‐Efficient Solvent for Organic Transformations

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An Overview of Recent Advances in Biomedical Applications of Click Chemistry

An Overview of Recent Advances in Biomedical Applications of Click Chemistry

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