Glycerol as a green solvent for enhancing the formulation of dextran methacrylate and gellan-based semi-interpenetrating polymer networks

Zoratto, Nicole; Matassa, Roberto; Montanari, Elita; Familiari, Giuseppe; Petralito, Stefania; Coviello, Tommasina; Meo, Chiara Di; Matricardi, Pietro

doi:10.1007/s10853-020-04732-1

Cited by 12 publications

(13 citation statements)

References 36 publications

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“…By controlling the chamber pressure and the cooling temperature, the collapse of the surface pores was avoided. [42,43] FT-IR spectra were acquired by an Is 50 model Thermo Fisher Scientific spectrophotometer equipped with a single reflection ATR diamond cell, in a spectral region between 4000 and 500 cm −1 . Following an optimized measurement protocol, Raman spectroscopy, XRD, and conductivity measurements were carried out on the freeze-dried samples compacted in the form of tablets by using a hydraulic press operating at a pressure of 6 × 10 3 kg cm −2 for 1 min.…”

Section: Characterization Techniquesmentioning

confidence: 99%

A New Strong‐Acid Free Route to Produce Xanthan Gum‐PANI Composite Scaffold Supporting Bioelectricity

Pescosolido

Montaina

Carcione

et al. 2023

Macromolecular Bioscience

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Conductive hybrid xanthan gum (XG)–polyaniline (PANI) biocomposites forming 3D structures able to mimic electrical biological functions are synthesized by a strong‐acid free medium. In situ aniline oxidative chemical polymerizations are performed in XG water dispersions to produce stable XG–PANI pseudoplastic fluids. XG–PANI composites with 3D architectures are obtained by subsequent freeze‐drying processes. The morphological investigation highlights the formation of porous structures; UV–vis and Raman spectroscopy characterizations assess the chemical structure of the produced composites. I–V measurements evidence electrical conductivity of the samples, while electrochemical analyses point out their capability to respond to electric stimuli with electron and ion exchanges in physiological‐like environment. Trial tests on prostate cancer cells evaluate biocompatibility of the XG–PANI composite. Obtained results demonstrate that a strong acid‐free route produces an electrically conductive and electrochemically active XG–PANI polymer composite. The investigation of charge transport and transfer, as well as of biocompatibility properties of composite materials produced in aqueous environments, brings new perspective for exploitation of such materials in biomedical applications. In particular, the developed strategy can be used to realize biomaterials working as scaffolds that require electrical stimulations for inducing cell growth and communication or for biosignals monitoring and analysis.

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Section: Characterization Techniquesmentioning

confidence: 99%

A New Strong‐Acid Free Route to Produce Xanthan Gum‐PANI Composite Scaffold Supporting Bioelectricity

Pescosolido

Montaina

Carcione

et al. 2023

Macromolecular Bioscience

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“…Surface observations of NHs on the outermost layer of the cornea in hydrated state without conductive coating were obtained using a variable pressure SEM (VP-SEM, Hitachi SU-3500). Experiments were performed at variable pressure combined with a cooling stage for limiting water vapour loss of the sample, during low-vacuum observations [37,38]. Images were recorded with the accelerating voltage of 8 kV, magnification of 1000× and working distance of 5.4 mm.…”

Section: Variable Pressure Scanning Electron Microscopy (Vp-sem)mentioning

confidence: 99%

Hyaluronan-Cholesterol Nanogels for the Enhancement of the Ocular Delivery of Therapeutics

et al. 2021

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The anatomy and physiology of the eye strongly limit the bioavailability of locally administered drugs. The entrapment of therapeutics into nanocarriers represents an effective strategy for the topical treatment of several ocular disorders, as they may protect the embedded molecules, enabling drug residence on the ocular surface and/or its penetration into different ocular compartments. The present work shows the activity of hyaluronan-cholesterol nanogels (NHs) as ocular permeation enhancers. Thanks to their bioadhesive properties, NHs firmly interact with the superficial corneal epithelium, without penetrating the stroma, thus modifying the transcorneal penetration of loaded therapeutics. Ex vivo transcorneal permeation experiments show that the permeation of hydrophilic drugs (i.e., tobramycin and diclofenac sodium salt), loaded in NHs, is significantly enhanced when compared to the free drug solutions. On the other side, the permeation of hydrophobic drugs (i.e., dexamethasone and piroxicam) is strongly dependent on the water solubility of the entrapped molecules. The obtained results suggest that NHs formulations can improve the ocular bioavailability of the instilled drugs by increasing their preocular retention time (hydrophobic drugs) or facilitating their permeation (hydrophilic drugs), thus opening the route for the application of HA-based NHs in the treatment of both anterior and posterior eye segment diseases.

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“…[23,24] By appropriate control of the chamber pressure, particular attention was paid to avoid crack formations of the content structures. [25] All samples were observed at an accelerating voltage depending on the features of the pressure used in the chamber to avoid radiation damage and drifting image, fatal for EDS multi-mapping analyses.…”

Section: Variable Pressure Scanning Electron Microscopymentioning

confidence: 99%

Direct imaging evidences of metal inorganic contaminants traced into cigarettes

Matassa

Cattaruzza

Sandorfi

et al. 2021

Journal of Hazardous Materials

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Today, environmental health research of adverse hybrid materials diffused by cigarette represents a new challenge for identifying new health risks directly related to the specific micro-sized materials in terms of their morpho-chemical features. Distinctive assumptions about the origin, the evolution? growth, and the functionalization of toxic elusive particles have been proposed by scientific research to attend the relevant toxicological aspects of observable behaviors. Therefore, direct morpho-chemical observations of the toxic hybrid particles are the most important factor for showing their adverse effects. Here, we report how metal inorganic particles, identified in three micrometric regions of the cigarette, evolve in their chemical size distributions into a self-assembled agglomerates ranging from ultrafine powder to large micrometric complex before and after smoking. Detailed morpho-chemical investigation on these metal inorganic materials interacting with cigarette components, quantified in situ through electron microscopy techniques, has been performed for one traditional and two heat-not-burn cigarettes of three different brands. The experimental informations gathered allowed us to figure out the evolution of the particles from the early stage (before smoking) to the final (after smoking) assembled in hazardous large agglomerates chemically manipulated and delivered by particles heat carrier, the smoke. In particular, our work shows the dual role of the adverse smoke, generated by burning and heating processes, capable of growing multi-elemental macro-aggregates and of transporting the toxic pollutants, thereby the diffusing of contaminants in the natural environmental is independent from the safety engineered features adopted by tobacco company. The reported results represent a valuable background toward the full comprehension of evolution of the toxic materials into cigarettes responsible of altering and destroying the already contaminated nature, especially for human health.

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Glycerol as a green solvent for enhancing the formulation of dextran methacrylate and gellan-based semi-interpenetrating polymer networks

Abstract: Glycerol as a green solvent for enhancing the formulation of dextran methacrylate and gellan-based semi-interpenetrating polymer networksFull Title: Glycerol as a green solvent for enhancing the formulation of dextran methacrylate and gellan-based semi-interpenetrating polymer networks

Cited by 12 publications

References 36 publications

A New Strong‐Acid Free Route to Produce Xanthan Gum‐PANI Composite Scaffold Supporting Bioelectricity

A New Strong‐Acid Free Route to Produce Xanthan Gum‐PANI Composite Scaffold Supporting Bioelectricity

Hyaluronan-Cholesterol Nanogels for the Enhancement of the Ocular Delivery of Therapeutics

Direct imaging evidences of metal inorganic contaminants traced into cigarettes

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