Glycemic Variability and Oxidative Stress:  A Link between Diabetes and Cardiovascular Disease?

Saisho, Yoshifumi

doi:10.3390/ijms151018381

Cited by 151 publications

(149 citation statements)

References 137 publications

(151 reference statements)

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“…In previous research (6,40,43), the results showed that oxidative stress and inflammation are two important mechanisms in glucose fluctuations that induce diabetes-associated cardiovascular damage. All of those results are observed in patients.…”

Section: Discussionmentioning

confidence: 99%

miR-1273g-3p participates in acute glucose fluctuation-induced autophagy, dysfunction, and proliferation attenuation in human umbilical vein endothelial cells

Guo

Sang

Yin

et al. 2016

American Journal of Physiology-Endocrinology and Metabolism

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-Acute glucose fluctuations (AGF) often cause high mortality among critically ill patients, but the mechanisms induced by AGF are not clear. Recent studies suggest that endothelial dysfunction is a key factor that leads to high mortality among critically ill patients. Our goal is to evaluate the phenomenon and mechanisms of endothelial dysfunction induced by AGF. In this study, the functions of human umbilical vein endothelial cells (HUVECs) were compared after treatment with sustained high glucose (SHG), AGF in two groups (AGF1 fluctuations between 5 and 16 mM and AGF2 fluctuations between 5 and 25 mM), and normal glucose levels as a control group (CTR). The medium of the groups was changed every 4 h. The influence of AGF on wound healing was also tested on C57BL/6 mice. The results show that cell proliferation, angiogenesis, and migration functions were injured in the SHG and both AGF groups. AGF2 group shows the worse condition in vitro. In vivo, the wound healing was delayed after the AGF treatment. Furthermore, the markers of apoptosis and autophagy were analyzed. We observed that the autophagy changed in all treatment groups, but apoptosis showed no change. To get to know the mechanism of dysfunction and autophagy, we performed the microRNA chip assay and real-time PCR and found miR-1273g-3p remarkably changed in AGF2 group. After the mimic and inhibitor of miR-1273g-3p were transfected during the AGF2 treatment, we found that the dysfunction and autophagy were partially enhanced by miR-1273g-3p mimic and reversed by miR-1273g-3p inhibitor in AGF2 group. Thus, we conclude that AGF can induce more dysfunction and autophagy, and miR-1273g-3p is also an important factor that leads to the injury. glucose fluctuations; endothelial dysfunction; wound healing; autophagy; miR-1273g-3pINCREASING GLYCEMIC VARIABILITY can greatly increase the risk of mortality among critically ill patients. Several previous studies suggest that the variability in glucose levels over time is an important determinant of mortality among critically ill patients (21,22,58). Alternatively, recent evidence shows that glucose fluctuations may influence the development of diabetic complications(4, 47) and may produce more serious injury in organ functions than sustained high blood glucose. Krinsley and Preiser (20) reported that if a blood glucose range of 70 -140 mg/dl is maintained for Ͼ80% of the time, the chances of survival of nondiabetic critically ill adults will be greatly increased. Organ injury induced by glucose toxicity is commonly observed in both intensive care units and endocrine departments. The damage is also observed in in vitro cell culture and animal studies. Therefore, some authors have proposed that "glycemic variability" is a new therapeutic challenge in diabetes and the critical care setting (7).The mechanism of the production of glucose fluctuations is variable in several studies (35)(36)(37)(38)(39)57) in both preclinical and clinical research studies. However, this is not appropriate for the critically ill patient...

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Section: Discussionmentioning

confidence: 99%

miR-1273g-3p participates in acute glucose fluctuation-induced autophagy, dysfunction, and proliferation attenuation in human umbilical vein endothelial cells

Guo

Sang

Yin

et al. 2016

American Journal of Physiology-Endocrinology and Metabolism

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“…CGM is a useful tool to assess glycemic variability as well as mean glucose [20]. Glycemic variability assessed by CGM has been shown to associate with oxidative stress/inflammatory markers, endothelial dysfunction and cognitive dysfunction, and proposed as one of the factors associated with CVD outcomes in patients with and without diabetes [20].…”

Section: Discussionmentioning

confidence: 99%

Association between severity of obstructive sleep apnea and glycated hemoglobin level in Japanese individuals with and without diabetes

et al. 2018

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Abstract. Aim of this study was to examine the association between the severity of obstructive sleep apnea (OSA) and dysglycemia in Japanese individuals with and without type 2 diabetes (T2DM). We enrolled 115 individuals diagnosed with OSA with an apnea hypopnea-index (AHI) ≥ 20 in whom continuous positive airway pressure (CPAP) therapy was introduced (N = 115, 44 with T2DM, age 62 ± 11 years, BMI 27.0 ± 4.4 kg/m 2 and AHI median 36.1; interquartile range 27.2-48.1). During admission, the severity of OSA was evaluated by polysomnography, and its association with glycated hemoglobin (HbA1c) level was examined. Continuous glucose monitoring (CGM) was also conducted during the admission in 94 individuals. Apnea-hypopnea index (AHI), non-rapid eye movement (REM) AHI, minimum peripheral capillary oxygen saturation (SpO 2 ) and percentage of sleep time (%TST) with SpO 2 < 90% were significantly associated with HbA1c level in total and non-diabetic individuals (all p < 0.05) but not in those with T2DM, the majority of whom were treated with antidiabetic medications. The associations of the non-REM AHI and %TST with SpO 2 < 90% with HbA1c level remained significant after adjustment for age, sex and BMI in non-diabetic and T2DM subjects treated with dietary therapy only. Mean glucose level, but not SD or coefficient of variation of glucose, assessed by CGM was significantly associated with AHI and non-REM AHI in non-diabetic subjects after adjustment for age, sex and BMI. In conclusion, the severity of OSA was associated with increased HbA1c level independently of BMI in Japanese individuals, especially in those without diabetes.

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“…Several pathways may be initiated due to hyperglycemia-induced OS: (1) The polyol pathway; (2) hexosamine pathway; (3) protein kinase C activation; and (4) formation of AGEs. [7][8][9] Any period of disease can be considered a period of stress, and therefore, some degree of hyperglycemia is normal during these times, and can be seen as initially protective and part of the adaptive response for survival. However, in acute and severe diseases, the resulting hyperglycemia can be much too high and require glycemic control therapy to manage.…”

Section: Resultsmentioning

confidence: 99%

Glucose Fluctuations and Activation of Oxidative Stress in Patients with Type II Diabetes Mellitus

Nayak¹,

Sharma²,

Patani³

et al. 2017

Indian Journal of Medical Biochemistry

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Glycemic Variability and Oxidative Stress: A Link between Diabetes and Cardiovascular Disease?

Cited by 151 publications

References 137 publications

miR-1273g-3p participates in acute glucose fluctuation-induced autophagy, dysfunction, and proliferation attenuation in human umbilical vein endothelial cells

miR-1273g-3p participates in acute glucose fluctuation-induced autophagy, dysfunction, and proliferation attenuation in human umbilical vein endothelial cells

Association between severity of obstructive sleep apnea and glycated hemoglobin level in Japanese individuals with and without diabetes

Glucose Fluctuations and Activation of Oxidative Stress in Patients with Type II Diabetes Mellitus

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