Glycemic Control and Hypoglycemia in Veterans Health Administration Patients Converted from Glyburide to Glipizide

Skoff, Rachel A.; Waterbury, Nancee V; Shaw, Robert F.; Egge, Jason A.; Cantrell, Matthew

doi:10.18553/jmcp.2011.17.9.664

Cited by 14 publications

(17 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1 However, unlike the small increase in glycated hemoglobin A1c reported by Skoff et al (7.42% vs. 7.08%), we found no significant change in A1c levels after discontinuation of glyburide.…”

Section: ■■ Glycemic Control Was Unchanged In Veterans Health Adminiscontrasting

confidence: 99%

Glycemic Control Was Unchanged in Veterans Health Administration Patients Converted from Glyburide to Glipizide

Aspinall¹,

Good²,

Cunningham³

2012

JMCP

View full text Add to dashboard Cite

“…1 However, unlike the small increase in glycated hemoglobin A1c reported by Skoff et al (7.42% vs. 7.08%), we found no significant change in A1c levels after discontinuation of glyburide.…”

Section: ■■ Glycemic Control Was Unchanged In Veterans Health Adminiscontrasting

confidence: 99%

Glycemic Control Was Unchanged in Veterans Health Administration Patients Converted from Glyburide to Glipizide

Aspinall¹,

Good²,

Cunningham³

2012

JMCP

View full text Add to dashboard Cite

“…Concern about flax use in older people may come from vascular effects reported in rats consuming a diet consisting of 20% flaxseed, which showed a vasorelaxant effect in hypertensive rats. In that animal study, however, the response in hypertensive rats to flaxseed was greater than that of normotensive rats and the mechanism was blood pressure-independent (Skoff et al, 2011). Hallund et al (2008) previously investigated the effects of giving 543 mg of SDG to healthy post-menopausal women aged 61 AE 7 years and saw no significant change in body weight, SBP, or DBP.…”

Section: Discussionmentioning

confidence: 94%

No evidence of hypoglycemia or hypotension in older adults during 6 months of flax lignan supplementation in a randomized controlled trial: A safety evaluation

Billinsky

Glew

Cornish

et al. 2013

Pharmaceutical Biology

View full text Add to dashboard Cite

Context: The natural health product, BeneFlax, is a standardized flaxseed [Linum usitatissimum L. (Linaceae)] lignan enriched product with evidence of product quality and known quantity of the bioactive component, lignan. The acceptance of this natural health product for its various health benefits requires greater evidence of its safety in the general population. Objective: We determined whether flaxseed lignan causes clinical hypoglycemia or hypotension in healthy older adults as an important aspect of safety. Materials and methods: Participants aged 49-87 years were randomized in a double-blind trial to receive flaxseed lignan (543 mg/day in BeneFlax) or placebo while completing a 6-month walking program. The 94 participants who completed the study were stratified by age (565 years versus !65 years) and treatment category to determine whether older adults were more susceptible to adverse effects. Results: After 6 months of treatment, average plasma glucose level (5.4 AE 0.6 mmol/L), systolic blood pressure (127 AE 14 mm Hg), and diastolic blood pressure (80 AE 9 mm Hg) were within normal clinical range. Controlling for sex and body mass index covariates resulted in no observed differences between plasma glucose or blood pressure measurements between treatment or age groups (p40.05). No incidents of hypoglycemia or hypotension were observed during BeneFlax treatment, suggesting that 543 mg falls at or below the no observable adverse effect level (NOAEL). Discussion and conclusion: These data suggest the flaxseed lignan product BeneFlax does not pose a risk of hypoglycemia or hypotension in healthy adults aged 49-87 years.

show abstract

“…This study has been described in detail elsewhere [24]. Briefly, data were collected through a multilevel, stratified, random survey of households that, on the basis of data from the 1999 national population census, are representative of the French population.…”

Section: Methodsmentioning

confidence: 99%

“…People who live in institutions (e.g. retirement homes, religious communities, prisons and hospitals), in mobile homes or who are homeless are not included, therefore almost 98% of the entire population is covered by the survey [24]. Using a combination of face-to-face interviews and self-administered questionnaires, the NHS includes data at both individual and household levels, including information about demographic and socioeconomic characteristics and health status, complementary insurance coverage and medical care consumption.…”

Section: Methodsmentioning

confidence: 99%

SRH and HrQOL: does social position impact differently on their link with health status?

et al. 2012

View full text Add to dashboard Cite

BackgroundSelf-rated Health (SRH) and health-related quality of life (HRQoL) are used to evaluate health disparities. Like all subjective measures of health, they are dependent on health expectations that are associated with socioeconomic characteristics. It is thus needed to analyse the influence played by socioeconomic position (SEP) on the relationship between these two indicators and health conditions if we aim to use them to study health disparities. Our objective is to assess the influence of SEP on the relationship between physical health status and subjective health status, measured by SRH and HRQoL using the SF-36 scale.MethodsWe used data from the French National Health Survey. SEP was assessed by years of education and household annual income. Physical health status was measured by functional limitations and chronic low back pain.ResultsRegardless of their health status, people with lower SEP were more likely than their more socially advantaged counterparts to report poor SRH and poorer HRQoL, using any of the indicators of SEP. The negative impact of chronic low back pain on SRH was relatively greater in people with a high SEP than in those with a low SEP. In contrast, chronic low back pain and functional limitations had less impact on physical and mental component scores of quality of life for socially advantaged men and women.ConclusionsBoth SRH and HRQoL were lower among those reporting functional limitations or chronic low back pain. However, the change varied according SEP and the measure. In relative term, the negative impact of a given health condition seems to be greater on SRH and lower on HRQoL for people with higher SEP in comparison with people with low SEP. Using SRH could thus decrease socioeconomic differences. In contrast using HRQoL could increase these differences, suggesting being cautious when using these indicators for analyzing health disparities.

show abstract

Glycemic Control and Hypoglycemia in Veterans Health Administration Patients Converted from Glyburide to Glipizide

Cited by 14 publications

References 17 publications

Glycemic Control Was Unchanged in Veterans Health Administration Patients Converted from Glyburide to Glipizide

Glycemic Control Was Unchanged in Veterans Health Administration Patients Converted from Glyburide to Glipizide

No evidence of hypoglycemia or hypotension in older adults during 6 months of flax lignan supplementation in a randomized controlled trial: A safety evaluation

SRH and HrQOL: does social position impact differently on their link with health status?

Contact Info

Product

Resources

About