Glycemia is associated with subclinical atherosclerosis through renal function in nondiabetic apparently healthy adults: a mediation analysis

The vicious circle of arterial elasticity, blood pressure, glycemia, and renal function

“…Additionally, PP has been linked with the degree of proteinuria and creatinine values [10]. However, the effect of PP on GFR was not addressed in the current study of Delialis et al [3].…”

“…1). Thus, they propose that the effect of fasting plasma glucose on PWV appears to be mediated through changes in GFR [3]. Undoubtedly, nephropathy constitutes one of the major microvascular complications of hyperglycemia in diabetes, with the insidious development of albuminuria and the resultant development of chronic kidney disease [4].…”