Glycemia after Betamethasone in Pregnant Women without Diabetes—Impact of Marginal Values in the 75-g OGTT

Kakoulidis, Ioannis; Ilias, Ιoannis; Linardi, Anastasia; Michou, Aikaterini; Milionis, Charalampos; Petychaki, Foteini; Venaki, Evangelia; Koukkou, Eftychia

doi:10.3390/healthcare8010040

Cited by 5 publications

(4 citation statements)

References 21 publications

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“…In addition, the anti-inflammatory drug bethametasone is also enriched for up regulating the reno-protective genes. It is known that bethametasone causes spikes in blood sugar ( 83 ). However, in general, glucocorticoids have been used alone or in combination with other drugs to treat glomerular diseases ( 84 ).…”

Section: Resultsmentioning

confidence: 99%

Enrichr-KG: bridging enrichment analysis across multiple libraries

Evangelista

Xie

Marino

et al. 2023

Nucleic Acids Research

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Gene and protein set enrichment analysis is a critical step in the analysis of data collected from omics experiments. Enrichr is a popular gene set enrichment analysis web-server search engine that contains hundreds of thousands of annotated gene sets. While Enrichr has been useful in providing enrichment analysis with many gene set libraries from different categories, integrating enrichment results across libraries and domains of knowledge can further hypothesis generation. To this end, Enrichr-KG is a knowledge graph database and a web-server application that combines selected gene set libraries from Enrichr for integrative enrichment analysis and visualization. The enrichment results are presented as subgraphs made of nodes and links that connect genes to their enriched terms. In addition, users of Enrichr-KG can add gene-gene links, as well as predicted genes to the subgraphs. This graphical representation of cross-library results with enriched and predicted genes can illuminate hidden associations between genes and annotated enriched terms from across datasets and resources. Enrichr-KG currently serves 26 gene set libraries from different categories that include transcription, pathways, ontologies, diseases/drugs, and cell types. To demonstrate the utility of Enrichr-KG we provide several case studies. Enrichr-KG is freely available at: https://maayanlab.cloud/enrichr-kg.

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Section: Resultsmentioning

confidence: 99%

Enrichr-KG: bridging enrichment analysis across multiple libraries

Evangelista

Xie

Marino

et al. 2023

Nucleic Acids Research

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“…Similar results were also shown by other studies. [17][18][19] It has been reported in a review article that blood sugar level must be checked before giving steroid. And patient should be monitored in the hospital for at least 5 days for fetomaternal surveillance.…”

Section: Effect Of Antenatal Corticosteroids On Maternal Blood Glucos...mentioning

confidence: 99%

Effect of Antenatal Corticosteroids on Maternal Blood Glucose Levels

2023

JPMI

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Objective: To study the effect of antenatal corticosteroids on maternal blood glucose levels.Methodology: This observational study was conducted in the Department of Obstetrics and Gynecology at Hayatabad Medical Complex, Peshawar, after obtaining ethical approval from the Institutional Ethical Review Board. All patients admitted to the labor suite for antenatal corticosteroids were included in the study, while patients with diabetes or any other medical disorder requiring corticosteroids were excluded. Patients were selected using a non-probability convenient sampling technique. They were given two doses of Betamethasone (12mg) intramuscularly, with a 24-hour interval between doses. Maternal blood sugar levels were checked before administering the first dose of Betamethasone. Subsequently, patients were placed on a sugar profile for five days. All the data were entered in a pre-designed proforma.Result: A total of 247 patients were included in the study. The majority of the patients were multigravida (50.20%) and belonged to the age group of 21-30 (50.20%). The mean age of the patients was 26.4 ± 2.3 years. The majority of the patients (72.46%) had deranged blood sugar levels, either falling within the range of impaired glucose levels or full-blown diabetes. Antenatal corticosteroids mainly affected fasting blood sugar (FBS) and post-prandial blood sugar levels. Conclusion:Antenatal corticosteroids administered to normoglycemic patients result in significant but transient hyperglycemia. However, in the majority of patients, blood sugar levels normalize within five days following the administration of corticosteroid doses.

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“…During the third trimester, in order to accelerate fetal lung maturation, glucocorticoids (GCs) are usually administered in high-risk pregnancies. However, GCs steadily increase plasma glucose levels making the administration of exogenous insulin in these GCs-treated women largely unavoidable [ 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Alpha-Methyldopa May Attenuate Insulin Demand in Women with Gestational Diabetes Treated with Betamethasone

et al. 2022

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Gestational diabetes mellitus (GDM) is associated with hypertensive disorders in pregnancy. Alpha-methyl-DOPA (αMD) is a commonly used medication for hypertension in pregnant women. This medication may be associated with alteration in insulin resistance and glucose homeostasis. The aim of the present study was to investigate in 152 pregnant women whether the demands of exogenous insulin in glucocorticoid-treated women during pregnancy are different between those with GDM and hypertension treated with αMD and those without hypertension. In the group of women with GDM under insulin treatment, who received αMD for hypertension, the increase in insulin needs was relatively lower by at least 30% of the pre-admission insulin dose compared to all of the remaining women not receiving αMD in the same group (9 women vs. 50 women, p = 0.035). Our work raises the hypothesis that αMD can favorably modulate insulin sensitivity in the third trimester of pregnancy in previously insulin-treated women with gestational diabetes who receive glucocorticoids.

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Glycemia after Betamethasone in Pregnant Women without Diabetes—Impact of Marginal Values in the 75-g OGTT

Cited by 5 publications

References 21 publications

Enrichr-KG: bridging enrichment analysis across multiple libraries

Enrichr-KG: bridging enrichment analysis across multiple libraries

Effect of Antenatal Corticosteroids on Maternal Blood Glucose Levels

Alpha-Methyldopa May Attenuate Insulin Demand in Women with Gestational Diabetes Treated with Betamethasone

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