Glycans modulate lipid binding in Lili-Mip lipocalin protein: insights from molecular simulations and protein network analyses
Harini SureshKumar,
Rajeswari Appadurai,
Anand Srivastava
Abstract:The unique viviparous Pacific Beetle cockroaches provide nutrition to their embryo by secreting milk proteins Lili-Mip, a lipid-binding glycoprotein that crystallises in-vivo. The resolved in-vivo crystal structure of variably glycosylated Lili-Mip shows a classical Lipocalin fold with an eight-stranded antiparallel beta-barrel enclosing a fatty acid. The availability of physiologically unaltered glycoprotein structure makes Lili-Mip a very attractive model system to investigate the role of glycans on protein … Show more
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