2014
DOI: 10.4155/tde.14.25
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Glycan-Targeted Drug Delivery for Intravesical Therapy: In the Footsteps of Uropathogenic Bacteria

Abstract: The human urothelium belongs to the most efficient biobarriers, and represents a highly rewarding but challenging target for local drug administration. Inadequate urothelial bioavailability is a major obstacle for successful treatment of bladder cancer and other diseases, yet little research has addressed the development of advanced delivery concepts for the intravesical route. A prominent example of how to overcome the urothelial barrier by means of specific biorecognition is the efficient cytoinvasion of UPE… Show more

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Cited by 2 publications
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“…They also function in the attachment of pathogens to cells and can cause cell clumping, such as in biofilms and cancer cells that helps cancer cells escape the body's defenses [7][8][9][10]. We use yeast (Saccharomyces cerevisiae) and lectin-derivatized agarose beads to identify glycans that can dissociate yeast from the beads as a model system for identifying glycans that can prevent binding of pathogens to cells [5].…”
Section: The Yeast Modelmentioning
confidence: 99%
“…They also function in the attachment of pathogens to cells and can cause cell clumping, such as in biofilms and cancer cells that helps cancer cells escape the body's defenses [7][8][9][10]. We use yeast (Saccharomyces cerevisiae) and lectin-derivatized agarose beads to identify glycans that can dissociate yeast from the beads as a model system for identifying glycans that can prevent binding of pathogens to cells [5].…”
Section: The Yeast Modelmentioning
confidence: 99%