Gly-Pro protects normal human dermal fibroblasts from UVA-induced damages via MAPK-NF-κB signaling pathway

Mohri, Shinsuke; Manabe, Yuki; Ejima, Akika; Satô, Kenji; Sugawara, Tatsuya

doi:10.1016/j.jphotobiol.2022.112601

Cited by 7 publications

(2 citation statements)

References 28 publications

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“…For example, glycylproline, spicamycin, and 2-aminoheptanoic acid (2-AHA) were up-regulated in DN vs. CN comparison. Glycylproline belongs to the family of proline-containing peptides [53], and previous studies have confirmed the protective role of this dipeptide during the cellular damage process through wound healing, and cell and tissue regeneration [54][55][56]. Spicamycin is a nucleoside antibiotic containing fatty acids of various chain lengths (C12-C18), and shows potent antitumor activity against certain human tumor cell lines in vitro [57,58].…”

Section: Discussionmentioning

confidence: 99%

Metabolic profiling of Mytilus coruscus mantle in response of shell repairing under acute acidification

Fan,

Wang,

Tang

et al. 2023

PLoS ONE

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Mytilus coruscus is an economically important marine bivalve mollusk found in the Yangtze River estuary, which experiences dramatic pH fluctuations due to seasonal freshwater input and suffer from shell fracture or injury in the natural environment. In this study, we used intact-shell and damaged-shell M. coruscus and performed metabolomic analysis, free amino acids analysis, calcium-positive staining, and intracellular calcium level tests in the mantle to investigate whether the mantle-specific metabolites can be induced by acute sea-water acidification and understand how the mantle responds to acute acidification during the shell repair process. We observed that both shell damage and acute acidification induced alterations in phospholipids, amino acids, nucleotides, organic acids, benzenoids, and their analogs and derivatives. Glycylproline, spicamycin, and 2-aminoheptanoic acid (2-AHA) are explicitly induced by shell damage. Betaine, aspartate, and oxidized glutathione are specifically induced by acute acidification. Our results show different metabolic patterns in the mussel mantle in response to different stressors, which can help elucidate the shell repair process under ocean acidification. furthermore, metabolic processes related to energy supply, cell function, signal transduction, and amino acid synthesis are disturbed by shell damage and/or acute acidification, indicating that both shell damage and acute acidification increased energy consumption, and disturb phospholipid synthesis, osmotic regulation, and redox balance. Free amino acid analysis and enzymatic activity assays partially confirmed our findings, highlighting the adaptation of M. coruscus to dramatic pH fluctuations in the Yangtze River estuary.

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Section: Discussionmentioning

confidence: 99%

Metabolic profiling of Mytilus coruscus mantle in response of shell repairing under acute acidification

Fan,

Wang,

Tang

et al. 2023

PLoS ONE

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“…This oxidative stress triggers the activation of a transcriptional factor called NF-κB in skin fibroblasts and keratinocytes. As a result, several inflammatory cytokines, such as TNF-α, IL-1, and IL-6, are upregulated [1][2][3]. Ultraviolet (UV) exposure, especially UVA, generates free radicals that can penetrate the dermal layer of the skin.…”

Section: Introductionmentioning

confidence: 99%

Anti-Aging Properties of Cannabis sativa Leaf Extract against UVA Irradiation

Luangpraditkun,

Pimjuk,

Phimnuan

et al. 2024

Cosmetics

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Hemp extract has garnered interest as a potential cosmeceutical agent with multifunctional activities, particularly in protecting against UV-induced skin cell aberrations and restoring aged skin cells. The ethanolic extract of Cannabis sativa leaves was prepared into an aqueous solution (CLES) to investigate its anti-photoaging ability. HPLC analysis revealed that the CLES contained 1.64 ± 0.01% w/w of cannabidiol and 0.11% w/w of ∆9-tetrahydrocannabinol. Additionally, the total phenolic content was found to be 4.08 ± 0.30 mg gallic acid equivalent per g of solution using the Folin–Ciocalteu method. The CLES exhibited potent scavenging activity using a DPPH assay, with an EC50 value of 277.9 ± 2.41 μg/mL, comparable to L-ascorbic acid, with 2.19 ± 0.28 μg/mL. The anti-photoaging potential of the CLES was evaluated using UVA-irradiated and in vitro-aged fibroblasts as a model. Pre-treatment with 20 μg/mL CLES for 24 h significantly alleviated the reduction in type I procollagen and suppressed the overproduction of MMP-1 and IL-6 induced by UVA. Moreover, the percentage of senescence-associated β-galactosidase-expressing cells decreased significantly to 11.9 ± 0.5% in the aged cells treated with CLES compared with untreated cells (18.8 ± 3.8%). These results strongly indicate the cosmeceutical potential of the CLES as an effective active agent for the anti-photoaging prevention and/or treatment.

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Preventive effects of dietary fucoxanthin on ultraviolet A induced photoaging in hairless mice

Liu,

Mohri,

Tsukamoto

et al. 2024

J Sci Food Agric

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BACKGROUNDRepeated exposure to ultraviolet A (UVA) irradiation, which can penetrate the epidermis and reach the dermis, is one of the major causes of skin photoaging. Photoaged skin is characterized clinically by generalized wrinkling, a dry and loose appearance, and seborrheic keratoses, along with skin barrier dysfunction. Fucoxanthin, a xanthophyll carotenoid with a specific allenic bond and 5,6‐monoepoxide in its structure, has been found to serve various functions as a food supplement. In the present study, the protective effects of orally administered fucoxanthin at relatively low concentrations (0.001% and 0.01%) against UVA induced photoaging were evaluated in vivo using hairless mice.RESULTSOral supplementation of 0.001% fucoxanthin was sufficient for its metabolites to accumulate in the skin, thereby inhibiting pathological changes induced by UVA irradiation, including impaired skin barrier function and accelerated wrinkle formation. Analysis of gene expression revealed that dietary fucoxanthin exerted antiphotoaging effects, possibly by modulating natural moisturizing factor (NMF) synthesis, desquamation, and ceramide composition in the epidermis, and by inhibiting the UVA induced degradation of collagen fibers and inflammation in the dermis.CONCLUSIONTaken together, our data indicate the potential application of dietary fucoxanthin as a novel ingredient in nutricosmetics for skin care against photoaging. © 2024 Society of Chemical Industry.

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Gly-Pro protects normal human dermal fibroblasts from UVA-induced damages via MAPK-NF-κB signaling pathway

Cited by 7 publications

References 28 publications

Metabolic profiling of Mytilus coruscus mantle in response of shell repairing under acute acidification

Metabolic profiling of Mytilus coruscus mantle in response of shell repairing under acute acidification

Anti-Aging Properties of Cannabis sativa Leaf Extract against UVA Irradiation

Preventive effects of dietary fucoxanthin on ultraviolet A induced photoaging in hairless mice

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