Gluten sensitivity: an emerging issue behind neurological impairment?

Volta, Umberto; Giorgio, Roberto De

doi:10.1016/s1474-4422(09)70357-6

Cited by 15 publications

(8 citation statements)

References 12 publications

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“…In the former group, depression and anxiety have been reported, 41 whereas in the latter there are a number of idiopathic neurological disorders, such as epilepsy with and without parieto-occipital calcifications, cerebellar ataxia, intellectual deterioration with attention/memory impairment, brain atrophy, peripheral neuropathy, multiplex myoclonus (Friedreich's disease) and multiple sclerosis. [42][43][44][45][46] Reproductive system dysfunction may be a sign of CD in both sexes. In females, there is a trend to late menarche, amenorrhea, early menopause and infertility, which respond positively to gluten withdrawal.…”

Section: Introductionmentioning

confidence: 99%

Celiac disease: diagnostic criteria in progress

2011

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Until a few years ago, celiac disease (CD) was thought to be a rare food intolerance that was confined to childhood and characterized by severe malabsorption and flat intestinal mucosa. Currently, CD is regarded as an autoimmune disorder that is common in the general population (affecting 1 in 100 individuals), with possible onset at any age and with many possible presentations. The identification of CD is challenging because it can begin not only with diarrhea and weight loss but also with atypical gastrointestinal (constipation and recurrent abdominal pain) and extra-intestinal symptoms (anemia, raised transaminases, osteoporosis, recurrent miscarriages, aphthous stomatitis and associated autoimmune disorders), or it could be completely symptomless. Over the last 20 years, the diagnostic accuracy of serology for CD has progressively increased with the development of highly reliable tests, such as the detection of IgA tissue transglutaminase and antiendomysial and IgG antideamidated gliadin peptide antibodies. The routine use of antibody markers has allowed researchers to discover a very high number of 'borderline' cases, characterized by positive serology and mild intestinal lesions or normal small intestine architecture, which can be classified as potential CD. Therefore, it is evident that the 'old celiac disease' with flat mucosa is only a part of the spectrum of CD. It is possible that serology could identify CD in its early stages, before the appearance of severe intestinal damage. In cases with a positive serology but with mild or absent intestinal lesions, the detection of HLA-DQ2 and HLA-DQ8 can help reinforce or exclude the diagnosis of gluten sensitivity.

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Section: Introductionmentioning

confidence: 99%

Celiac disease: diagnostic criteria in progress

2011

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“…It has been noted that adherence to a strict gluten-free diet sees an improvement in ataxic symptoms (Hadjivassiliou et al, 2006); however, prolonged exposure to gluten appears to cause permanent and irreparable nerve damage suggesting the need for prompt recognition and treatment to prevent progression (Volta & deGiorgio, 2010;Lauret & Rodrigo, 2013). The evidence for a gluten free diet in patients with MS is inconclusive, with papers suggesting there was no definitive evidence that such a diet conferred a benefit to the management of MS (Hewson et al, 1984;Schmitz et al, 2015), whilst Rodrigo et al (2014) suggested the preliminary findings of their recent randomised controlled trial had found that a gluten free diet improved the clinical and physical status of patients and seemingly exerted a neuroprotective effect.…”

Section: Clinical Features and Presentation Of Coeliac Disease And Mumentioning

confidence: 99%

Coeliac disease: neurological symptoms and association with multiple sclerosis

Smyth

Abel

2016

British Journal of Neuroscience Nursing

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 Coeliac disease and MS are common conditions and the cause of considerable morbidity, reduced quality of life and mortality  There are similarities in the symptom experience, presentation and clinical course of both conditions  Some studies suggests an association between coeliac disease and MS  As our knowledge of immunology develops and the relationship between auto-immune diseases evolves, the MS nurses role will need to advance to better assess and address the needs of this particular client group Coeliac disease (CD) and Multiple Sclerosis (MS) are common and complex auto-immune conditions associated with significant morbidity and mortality. This article will present a description of both conditions, the main neurological manifestations associated with CD and describe the putative relationship between the two conditions.

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“…The neurological manifestations are also immune mediated, and both cellular and humoral responses take place [55, 58]. Several antibodies have been associated to neurological damage such as IgG antibodies against gliadin, IgG-deamidated gliadin peptide antibodies, IgA antibodies against endomysium, and IgA antibodies against different transglutaminases, specially the anti-transglutaminase 6 antibodies [50, 55, 56, 58]. Postmortem analyses and peripheral nerve biopsies showed lymphocytic infiltrates with perivascular cuffing as the pathologic findings [57, 58].…”

Section: Specific Autoimmune-disease-related Snmentioning

confidence: 99%

Sensory Neuronopathy and Autoimmune Diseases

Martínez

Nunes

Nucci

et al. 2012

Autoimmune Diseases

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Sensory neuronopathies (SNs) are a specific subgroup of peripheral nervous system diseases characterized by primary degeneration of dorsal root ganglia and their projections. Multifocal sensory symptoms often associated to ataxia are the classical features of SN. Several different etiologies have been described for SNs, but immune-mediated damage plays a key role in most cases. SN may herald the onset of some systemic autoimmune diseases, which further emphasizes how important the recognition of SN is in clinical practice. We have thus reviewed available clinical, neurophysiological, and therapeutic data on autoimmune disease-related SN, namely, in patients with Sjögren's syndrome, autoimmune hepatitis, and celiac disease.

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Gluten sensitivity: an emerging issue behind neurological impairment?

Cited by 15 publications

References 12 publications

Celiac disease: diagnostic criteria in progress

Celiac disease: diagnostic criteria in progress

Coeliac disease: neurological symptoms and association with multiple sclerosis

Sensory Neuronopathy and Autoimmune Diseases

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