Gluten-Sensitive Enteropathy in Patients with Insulin-Dependent Diabetes Mellitus

Rensch, Michael J.; Merenich, John A.; Lieberman, Michael D.; Long, B. D.; Davis, Dirk R.; McNally, Peter R.

doi:10.7326/0003-4819-124-6-199603150-00004

Cited by 64 publications

(25 citation statements)

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“…the HLA-DQ2-positive) individuals may be a possible trigger for both T1DM and CD [29]. It is interesting, however, that in adult patients with T1DM [30] the prevalence of CD seems to increase with diabetes duration, which is in accordance with the previously suggested natural history of the development of autoimmunity [24]. …”

Section: Discussionsupporting

confidence: 71%

Screening for Associated Autoimmunity in Children and Adolescents with Type 1 Diabetes Mellitus (T1DM)

et al. 2009

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Background/Aims: Type 1 diabetes (T1DM) is associated with autoimmune thyroid, celiac, autoimmune gastric and Addison’s disease. Our aim was to investigate the prevalence of associated autoantibodies in relation to the demographic and β-cell autoantibody status (anti-GAD). Methods: Antibodies against thyroid peroxidase (anti-TPO), thyroglobulin (anti-Tg), tissue transglutaminase (anti-tTG IgA), parietal cells (APCA) and adrenal tissue (AAA) were measured in 144 children with T1DM with a mean ± SD age of 12.3 ± 4.6 years and a diabetes duration of 4.6 ± 3.8 years. Results: The prevalence of antibody positivity among our patients was: anti-GAD 53.2%, anti-thyroid (anti-TPO 17.4%, anti-Tg 11.1%); anti-tTG IgA 7.6%, APCA 4.0%, and AAA 0%. Among the children with positive anti-thyroid antibodies, 60% developed autoimmune thyroiditis, while among those anti-tTG IgA positive, 62.5% developed biopsy-confirmed celiac disease. Female gender was more frequent among anti-tTG IgA-positive patients (OR 4.47, p = 0.068), while increasing age was associated with anti-Tg positivity (OR 22.9, p = 0.041). The presence of anti-thyroid antibodies was associated with the presence of anti-GAD (OR 1.45, p = 0.01) and parietal cell antibodies (OR 4.98, p = 0.09). Conclusion: Among T1DM patients, the prevalence rates of anti-thyroid and parietal cell antibodies increased with age and diabetes duration. As the presence of anti-GAD was associated with gastric and thyroid autoimmunity, it could serve as marker for the development of additional autoimmunity in adolescents with diabetes.

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Section: Discussionsupporting

confidence: 71%

Screening for Associated Autoimmunity in Children and Adolescents with Type 1 Diabetes Mellitus (T1DM)

et al. 2009

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“…Because EMA-IgA is a very sensitive screening test for CD, the estimated prevalence of CD in the population has increased (15,16). Although three subjects were seropositive for EMA-IgA, AGA-IgA was only detected in one of them.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of autoimmune thyroiditis and celiac disease in children with insulin-dependent diabetes mellitus in the Thrace region of Turkey

Soyucen

Yılmaz²,

Çeltik³

et al. 2010

Turk J Gastroenterol

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“…For example, the prevalence of occult gastrointestinal bleeding 4 appears to be more common among patients with insulindependent diabetes mellitus, 5 while reduced activation of natural killer cells was observed in coeliac blood exposed to gliadin. 6 Thus, for the safety of patients, a lifelong strict gluten-free diet is mandatory.…”

Section: Introductionmentioning

confidence: 99%

Production of gluten‐free bread using soybean flour

et al. 2004

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The effect of soybean flour on gluten-free bread quality was studied. Full-fat enzyme-active, semiactive and inactive soybean flours were evaluated. Active soybean flour improved the volume and structure of gluten-free bread, while semiactive and inactive soybean flours did not have positive effects on bread quality. The particle size and concentration of the soybean flours also affected bread quality. Levels of addition between 125 and 150 g kg −1 and particle sizes between 90 and 120 µm of active soybean flour yielded the best results. Heating the active soybean flour destroyed its improving effect. The analysis of proteins by sodium dodecyl sulphate polyacrylamide gel electrophoresis and size exclusion chromatography showed that heating soybean flour at 60-200 • C caused protein aggregation. The overall results indicated that the addition of active soybean flour improved gluten-free bread quality, and this effect seemed to be due to both the structural proteins and the enzymatic activities of the soybean flour.

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Gluten-Sensitive Enteropathy in Patients with Insulin-Dependent Diabetes Mellitus

Abstract: Celiac disease appears to be more common among patients with insulin-dependent diabetes mellitus than in the general U.S. population (p less than 0.001). Two of the three patients with coexistent disease in this study had subclinical or latent celiac disease.

Cited by 64 publications

References 0 publications

Screening for Associated Autoimmunity in Children and Adolescents with Type 1 Diabetes Mellitus (T1DM)

Screening for Associated Autoimmunity in Children and Adolescents with Type 1 Diabetes Mellitus (T1DM)

Seroprevalence of autoimmune thyroiditis and celiac disease in children with insulin-dependent diabetes mellitus in the Thrace region of Turkey

Production of gluten‐free bread using soybean flour

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