Gluten migraine

Kopishinskaya, S V; Густов, А. В.

doi:10.17116/jnevro20151158113-17

Cited by 5 publications

(4 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is estimated that about 21-28% of patients with CD have migraine [104][105][106]. Migraine-like headache may represent the initial feature of CD [103,[107][108][109]. Some studies suggest that evidence of occipital and parieto-occipital calcifications and white matter abnormalities at brain neuroimaging are associated with comorbid CD in subjects with migraine [103,[110][111][112].…”

Section: Celiac Diseasementioning

confidence: 99%

Gut-brain Axis and migraine headache: a comprehensive review

et al. 2020

View full text Add to dashboard Cite

The terminology "gut-brain axis "points out a bidirectional relationship between the GI system and the central nervous system (CNS). To date, several researches have shown that migraine is associated with some gastrointestinal (GI) disorders such as Helicobacter pylori (HP) infection, irritable bowel syndrome (IBS), and celiac disease (CD). The present review article aims to discuss the direct and indirect evidence suggesting relationships between migraine and the gut-brain axis. However, the mechanisms explaining how the gut and the brain may interact in patients with migraine are not entirely clear. Studies suggest that this interaction seems to be influenced by multiple factors such as inflammatory mediators (IL-1β, IL-6, IL-8, and TNF-α), gut microbiota profile, neuropeptides and serotonin pathway, stress hormones and nutritional substances. Neuropeptides including CGRP, SP, VIP, NPY are thought to have antimicrobial impact on a variety of the gut bacterial strains and thus speculated to be involved in the bidirectional relationship between the gut and the brain. According to the current knowledge, migraine headache in patients harboring HP might be improved following the bacteria eradication. Migraineurs with long headache history and high headache frequency have a higher chance of being diagnosed with IBS. IBS and migraine share some similarities and can alter gut microflora composition and thereby may affect the gut-brain axis and inflammatory status. Migraine has been also associated with CD and the condition should be searched particularly in patients with migraine with occipital and parieto-occipital calcification at brain neuroimaging. In those patients, gluten-free diet can also be effective in reducing migraine frequency. It has also been proposed that migraine may be improved by dietary approaches with beneficial effects on gut microbiota and gut-brain axis including appropriate consumption of fiber per day, adhering to a low glycemic index diet, supplementation with vitamin D, omega-3 and probiotics as well as weight loss dietary plans for overweight and obese patients.

show abstract

Section: Celiac Diseasementioning

confidence: 99%

Gut-brain Axis and migraine headache: a comprehensive review

et al. 2020

View full text Add to dashboard Cite

show abstract

“…There is evidence that migraine and GI disorders share a common pathophysiology, which is thought to occur through the interaction of several factors, including inflammatory mediators, gut microbiota, neuropeptides, and the serotonin (5-HT) pathway [25,46]. Individuals diagnosed with celiac disease (CD), an autoimmune disorder triggered by gluten peptides, exhibit a higher occurrence of migraines in comparison to those without the condition, and conversely, individuals with migraines have a higher prevalence of CD [50,58,59]. The link between migraines and CD can be attributed to several simultaneous mechanisms, encompassing the activation of pro-inflammatory cytokines due to gluten, deficiencies in vital vitamins and essential elements, disturbances in vascular tone, and an increased sensitivity of the nervous system [26,60].…”

Section: Migraine the Microbiome And Gi Disordersmentioning

confidence: 99%

All Roads Lead to the Gut: The Importance of the Microbiota and Diet in Migraine

Spekker,

Nagy-Grócz

2023

Neurology International

View full text Add to dashboard Cite

Migraine, a prevalent neurological condition and the third most common disease globally, places a significant economic burden on society. Despite extensive research efforts, the precise underlying mechanism of the disease remains incompletely comprehended. Nevertheless, it is established that the activation and sensitization of the trigeminal system are crucial during migraine attacks, and specific substances have been recognized for their distinct involvement in the pathomechanism of migraine. Recently, an expanding body of data indicates that migraine attacks can be prevented and treated through dietary means. It is important to highlight that the various diets available pose risks for patients without professional guidance. This comprehensive overview explores the connection between migraine, the gut microbiome, and gastrointestinal disorders. It provides insight into migraine-triggering foods, and discusses potential diets to help reduce the frequency and severity of migraine attacks. Additionally, it delves into the benefits of using pre- and probiotics as adjunctive therapy in migraine treatment.

show abstract

“…A study conducted in 2015 Russia by Kopishinskaya and Gustov, included 200 patients with CD and 100 patients without CD. The subjects were asked to keep a headache diary during the course of six months [ 32 ]. It was discovered that patients with CD experienced headaches four times more often than the control group (48.5%; p<0.001), and the frequency of the migraine attacks was 2.5 times higher than the control group (р=0.004).…”

Section: Reviewmentioning

confidence: 99%

“…It was discovered that patients with CD experienced headaches four times more often than the control group (48.5%; p<0.001), and the frequency of the migraine attacks was 2.5 times higher than the control group (р=0.004). In addition, it was found that migraine attacks were more common in patients aged 50 years and above [ 32 ]. Another study conducted in Sweden 2016 by Lebwohl et al, included 28,638 patients with CD and 143,126 controls and found that a headache-related visit to the hospital occurred in 4.7% of the patients with CD and 2.9% in the controls.…”

Section: Reviewmentioning

confidence: 99%

Celiac Disease, Beyond the Bowel: A Review of Its Neurological Manifestations

Patel¹,

Shreya²,

Zamora³

et al. 2021

Cureus

View full text Add to dashboard Cite

Celiac disease (CD) is a multi-systemic autoimmune condition that causes a hyperinflammatory response when gluten is ingested. There has been a shift in the clinical presentation of CD from a mere malabsorption disorder to an autoimmune condition that affects multiple organ systems, which could increase the rate of hospitalizations and a decreased quality of life. This article has compiled various studies that have explored the neurological manifestations of celiac disease, their epidemiology, possible pathogenic mechanisms, diagnosis, and treatment. The most common neurological conditions include gluten ataxia (GA), gluten neuropathy, gluten encephalopathy, and epilepsy which usually present as sporadic diseases which are difficult to diagnose in the absence of gastrointestinal (GI) symptoms. The treatment for most of these conditions is a gluten-free diet (GFD) regardless of GI involvement.

show abstract

Gluten migraine

Cited by 5 publications

References 18 publications

Gut-brain Axis and migraine headache: a comprehensive review

Gut-brain Axis and migraine headache: a comprehensive review

All Roads Lead to the Gut: The Importance of the Microbiota and Diet in Migraine

Celiac Disease, Beyond the Bowel: A Review of Its Neurological Manifestations

Contact Info

Product

Resources

About