Gluten-Free Diet Induces Regression of T-Cell Activation in the Rectal Mucosa of Patients With Celiac Disease

Cellier, Christophe; Cervoni, Jean Paul; Patey, Natacha; Marteau, Philippe; Landi, Bruno; Cerf‐Bensussan, Nadine; Barbier, J; Brousse, Nicole

doi:10.1111/j.1572-0241.1998.00439.x

Cited by 20 publications

(6 citation statements)

References 17 publications

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“…This finding is similar to that found by other authors and our group in previous works both in the gut and other regions of the gastrointestinal tract of the rabbit (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)29).…”

Section: Discussionsupporting

confidence: 82%

“…Besides, high amounts of potentially antigenic food macromolecules reach distal regions of the colon due to the physiologic process of cecotrophy (18)(19)(20). The rectum is a part of the common immune mucosal system (CMIS), so histopathological and immunological modifications due to sensitization and challenge may be evaluated in the rectal mucosa (21)(22)(23)(24).…”

Section: Introductionmentioning

confidence: 99%

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Immunopathological modifications in the rectal mucosa from an animal model of food allergy

Vinuesa

Bassan

Roma

et al. 2005

Rev. esp. enferm. dig.

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Immunopathological modifications in the rectal mucosa from an animal model of food allergy

Vinuesa

Bassan

Roma

et al. 2005

Rev. esp. enferm. dig.

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“…Although the small intestinal mucosa is the main site of the gut's involvement in CD, other mucosal surfaces (such as oral, gastric, rectal, terminal ileum, and esophageal) belonging to the gastrointestinal tract and gut-associated lymphoid tissue (GALT), can also be involved [25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40]. Gluten-driven T-cell activation can be demonstrated in all these sites.…”

Section: Role Of the Mouth And Oral Mucosa In CD Studiesmentioning

confidence: 99%

The Production of the Oral Mucosa of Antiendomysial and Anti—Tissue-Transglutaminase Antibodies in Patients with Celiac Disease: A Review

Compilato¹,

Campisi²,

Pastore

et al. 2010

The Scientific World JOURNAL

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Celiac disease (CD) is a lifelong, T cell—mediated enteropathy, triggered by the ingestion of gluten and related prolamins in genetically susceptible subjects, resulting in minor intestinal mucosal injury, including villous atrophy with crypt hyperplasia and intraepithelial lymphocytosis, and subsequent nutrient malabsorption. Although serological tests for antiendomysial (EMA) and anti—tissue transglutaminase (anti-tTG) autoantibodies are used to screen and follow up on patients with CD, diagnostic confirmation is still based on the histological examination of the small intestinal mucosa. Although the small intestinal mucosa is the main site of the gut involved in CD, other mucosal surfaces (such as gastric, rectal, ileal, and esophageal) belonging to the gastrointestinal tract and the gut-associated lymphoid tissue (GALT) can also be involved. A site that could be studied less invasively is the mouth, as it is the first part of the gastrointestinal system and a part of the GALT. Indeed, not only have various oral ailments been reported as possible atypical aspects of CD, but it has been also demonstrated that inflammatory changes occur after oral supramucosal application and a submucosal injection of gliadin into the oral mucosa of CD patients. However, to date, only two studies have assessed the capacity of the oral mucosa of untreated CD patients to EMA and anti-tTG antibodies. In this paper, we will review studies that evaluate the capacity of the oral mucosa to produce specific CD autoantibodies. Discrepancies in sensitivity from the two studies have revealed that biopsy is still not an adequate procedure for the routine diagnostic purposes of CD patients, and a more in-depth evaluation on a larger sample size with standardized collection and analysis methods is merited. However, the demonstration of immunological reactivity to the gluten ingestion of the oral mucosa of CD, in terms of IgA EMA and anti-tTG production, needs to be further evaluated in order to verify whether the oral mucosa is colonized by lymphocytes activated in the intestine or if gluten could stimulate naïve lymphocytes directly in the oral mucosa. This would have important implications for the pathogenesis, diagnosis, and treatment of CD.

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“…The rectum belongs to the common immune mucosal system (CIMS), which determines that the sensitization processes and post challenge with food antigens produce histopathological and immunological modifications, which may be evaluated in the rectal mucosa (26,27).…”

Section: Introductionmentioning

confidence: 99%

Montelukast treatment (cysteinyl leukotriene receptor antagonist) in a model of food allergy: modifications in lymphatic cell population from rectal mucosa

Vinuesa

Bassan

et al. 2010

Rev. esp. enferm. dig.

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Gluten-Free Diet Induces Regression of T-Cell Activation in the Rectal Mucosa of Patients With Celiac Disease

Cited by 20 publications

References 17 publications

Immunopathological modifications in the rectal mucosa from an animal model of food allergy

Immunopathological modifications in the rectal mucosa from an animal model of food allergy

The Production of the Oral Mucosa of Antiendomysial and Anti—Tissue-Transglutaminase Antibodies in Patients with Celiac Disease: A Review

Montelukast treatment (cysteinyl leukotriene receptor antagonist) in a model of food allergy: modifications in lymphatic cell population from rectal mucosa

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