Gluten-Free, Casein-Free Diet for Children with Autism Spectrum Disorder: A Case-Controlled Study

Saad, Khaled; Shabaan, Islam; Hassan, Abd-El-Monem M.; Ezzat, Mohamed; Abouzed, Mohamed A.; Hamed, Yasser; Ibrahim, Mohamed Fahmy M.; Gad, Eman F.

doi:10.4103/jpbs.jpbs_1074_23

Cited by 3 publications

(2 citation statements)

References 18 publications

(33 reference statements)

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“…Six studies identified positive changes in autistic behaviour [11,30,31,[48][49][50]. Three studies showed improvement in cognitive, behavioural, and communication symptoms among children with ASD following the implementation of the GFCF diet [11,30,31].…”

Section: Cognitive Improvementsmentioning

confidence: 99%

“…A recent meta-analysis showed that there was a relationship between adherence to the GFCF diet and the behaviour of autistic children [48]. Additionally, a case-control study showed improvement in autistic behaviour [49]. Additionally, a systematic review and metaanalysis showed that the GFCF diet can reduce stereotypical behaviours and improve the cognition of children with ASD [50].…”

Section: Cognitive Improvementsmentioning

confidence: 99%

See 1 more Smart Citation

Impact of Gluten-Free and Casein-Free diet on the quality of life of Autistic children and Adolescents: A Scoping review

Zafirovski,

Aleksoska,

Thomas

et al. 2024

Preprint

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Background: Gluten and casein-containing foods could aggravate the symptoms of children and adolescents with autism spectrum disorder (ASD), and subsequently impact their quality of life. However, there is a mixed opinion among researchers concerning the impact of alternative diet on reducing ASD symptoms. Objective: This scoping review aimed at examining the impact of the ‘’gluten-free, casein-free’’ (GFCF) diet on health outcomes and the quality of life among autistic children and adolescents. Methods: A scoping review of the literature was performed following the Joanna Briggs Institute (JBI) guidelines. Four databases including EbscoHost, Medline, CINAHL and ProQuest were used to obtain subject-specific studies relevant to the research question and published between July 2013 and March 2024. A comprehensive search using keywords such as “autism spectrum disorder”, “gluten-free diet”, and “casein-free diet” was conducted to obtain articles related to the research focus area. Only full-text, peer-reviewed, written in English articles were selected. Data extraction and data analysis were performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses- extension to Scoping Review (PRISMA-ScR) protocol. Results: From the initial 586 studies a total of 27 articles were included in the final analysis of the review. The thematic analysis included ‘GFCF diet and improvement of the core autistic symptoms’’, “the gut-brain link’’, ‘’dietary interventions and autism’’, ‘’possible side effects due to the GCFC diet’’, and ‘’ inconclusive studies and mixed opinions’’. Majority of the studies showed positive effect of the GFCF diet on a variety of autistic symptoms including positive changes in cognitive skills, behaviour, and gastrointestinal symptoms while some showed conflicting evidence. Conclusion: The currently available evidence on the impact of ‘GFCF’’ diet on the quality of life of autistic children and adolescents may warrant potentially effective interventions for alleviating symptoms of autism spectrum disorders. However, this scoping review highlighted the need for more research to provide more reliable evidence on the health outcomes and quality of life of ASD sufferers to guide practice.

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Section: Cognitive Improvementsmentioning

confidence: 99%

Section: Cognitive Improvementsmentioning

confidence: 99%

Impact of Gluten-Free and Casein-Free diet on the quality of life of Autistic children and Adolescents: A Scoping review

Zafirovski,

Aleksoska,

Thomas

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Examining the association between autism spectrum disorder and atopic eczema: meta-analysis of current evidence

Elgenidy,

Gad,

Shabaan

et al. 2024

Pediatr Res

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Impact of Gluten-Free and Casein-Free Diet on Behavioural Outcomes and Quality of Life of Autistic Children and Adolescents: A Scoping Review

Zafirovski,

Aleksoska,

Thomas

et al. 2024

Children

View full text Add to dashboard Cite

Background: Gluten- and casein-containing foods could aggravate the symptoms of children and adolescents with autism spectrum disorder (ASD), and subsequently impact their quality of life. However, there is a mixed opinion among researchers concerning the impact of alternative diet on reducing ASD symptoms. Objective: This scoping review aimed at examining the impact of the “gluten-free, casein-free” (GFCF) diet on health outcomes and the quality of life among autistic children and adolescents. Methods: A scoping review of the literature was performed following the Joanna Briggs Institute (JBI) guidelines. Four databases, including EbscoHost, Medline, CINAHL, and ProQuest, were used to obtain subject-specific studies relevant to the research question and published between July 2013 and March 2024. A comprehensive search using keywords such as “autism spectrum disorder”, “gluten-free diet”, and “casein-free diet” was conducted to obtain articles related to the research focus area. Only full-text, peer-reviewed, written in English articles were selected. Data extraction and data analysis were performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses-extension to Scoping Review (PRISMA-ScR) protocol. Results: From the initial 586 studies, a total of 27 articles were included in the final analysis of the review. The thematic analysis included “GFCF diet and improvement of the core autistic symptoms”, “the gut–brain link”, “dietary interventions and autism”, “possible side effects due to the GCFC diet”, and “inconclusive studies and mixed opinions”. A majority of the studies showed a positive effect of the GFCF diet on a variety of autistic symptoms, including positive changes in cognitive skills, behaviour, and gastrointestinal symptoms, while some showed conflicting evidence. Conclusions: The currently available evidence on the impact of the “GFCF” diet on the quality of life of autistic children and adolescents may warrant potentially effective interventions for alleviating symptoms of autism spectrum disorders. However, this scoping review highlights the need for more research to provide more reliable evidence on the health outcomes and quality of life of ASD sufferers to guide practice.

show abstract

Gluten-Free, Casein-Free Diet for Children with Autism Spectrum Disorder: A Case-Controlled Study

Cited by 3 publications

References 18 publications

Impact of Gluten-Free and Casein-Free diet on the quality of life of Autistic children and Adolescents: A Scoping review

Impact of Gluten-Free and Casein-Free diet on the quality of life of Autistic children and Adolescents: A Scoping review

Examining the association between autism spectrum disorder and atopic eczema: meta-analysis of current evidence

Impact of Gluten-Free and Casein-Free Diet on Behavioural Outcomes and Quality of Life of Autistic Children and Adolescents: A Scoping Review

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