Glutathione transferase fromPlasmodium falciparum– Interaction with malagashanine and selected plant natural products

Yeast-Mediated Xanthone Synthesis through Oxidative Intramolecular Cyclization

“…Guttiferone A 1 was isolated from Symphonia globulifera roots and recently from Garcinia livingstonei and Garcinia macrophylla. This natural product exhibits a wide pharmacological profile, with anti-HIV, cytotoxic, − trypanocidal, , antiplasmodial, − leishmanicidal, ,, and antibacterial effects. In an interesting way, guttiferone A shows good radical scavenging activity and could be a lead in the search for new antimalarial drugs. , Several actions of guttiferone A toward cell pathologies and specific enzymatic activities have also been reported. , …”

Prospect of Natural Compounds Against Malaria: A Review

“…Atovaquone (synthetic organic compound) belongs to the naphthoquinone class of drugs, used as a fixed-dose combined with proguanil to treat children and adults with complicated malaria cases caused by P. falciparum 29 and is also used to prevent malaria in travelers. 146…”

New solutions using natural products

“…7.22 ) is a simple tripeptide, consisting of glutamic acid, cysteine, and glycine. It is considered one of the most powerful endogenous antioxidants, capable of preventing damage to cellular components caused by reactive forms of oxygen, radicals, and heavy metals, although its role in stress management and efficient defense against pathogens are still under study ( Mangoyi et al, 2010 ). Besides its antioxidant defense and free radical scavenging, glutathione regenerates important antioxidants such as vitamins C and E. GSH exists in every cell of the human body, but it is also present in many other organisms, including fungi and bacteria.…”