Glutathione System and Activity of NADPH-Generating Enzymes in the Liver of Intact Rats and Animals with Toxic Hepatitis Receiving Melatonin

Пашков, А. Н.; Попов, С. С.; Semenikhina, A. V.; Rakhmanova, T. I.

doi:10.1007/s10517-005-0346-7

Cited by 7 publications

(5 citation statements)

References 6 publications

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“…MDH, ICD and G-6-PDH are responsible for generating NADPH for the support of lipogenesis while hormone-sensitive lipase has the opposite effect of mobilizing fatty acids from adipocytes into the blood stream in the process of lipolysis. Lipoprotein lipase in adipose tissue is involved in the movement of fatty acids from TG in blood chylomicrons and VLDL to the adipocytes (Gondret and Lebret, 2002;Xu et al, 2003;Kokta and Dodson, 2004;Pashkov et al, 2005). At 42 days of age, the activities of NADPHgenerating enzymes were significantly decreased in liver and abdominal fat by dietary dihydropyridine, whereas HSL was significantly increased.…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary dihydropyridine supplementation on growth performance and lipid metabolism of broiler chickens

Niu¹,

Liu²,

Min³

et al. 2010

CZECH J ANIM SCI

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An experiment was conducted to investigate the effects of dihydropyridine supplementation on growth performance and lipid metabolism of broilers. A total of 480 one-day-old female Arbor Acres broiler chicks were randomly divided into four groups, each group had six replications of 20 birds. Each group was fed a maize-soybean meal diet supplemented with 0, 100, 200, 300 mg/kg dihydropyridine, respectively, for six weeks. At 42 days of age, body weight and feed intake were not affected by dihydropyridine, while feed efficiency was significantly increased by 8.4%, 15.0% and 12.0%, respectively (P < 0.05). The percentage of abdominal fat and the percentage of liver fat were reduced by 24.5%, 25.9%, 23.3%, and 23.6%, 26.7%, 26.0%, respectively (P < 0.05). The higher level of dietary dihydropyridine (200 or 300 mg/kg) increased the hormone-sensitive triglyceride lipase activity in liver and abdominal fat (P < 0.05). The lipoprotein lipase activity in abdominal fat was significantly decreased by dihydropyridine (P < 0.05). The activity of glucose-6-phosphate dehydrogenase and malic dehydrogenase in liver was significantly reduced, whereas the isocitrate dehydrogenase activity in liver was not affected by dietary dihydropyridine. The content of cAMP was significantly increased by dihydropyridine, but malondialdehyde content was decreased (P < 0.05). Dihydropyridine at doses of 100 and 200 mg/kg increased apolipoprotein B (P < 0.05), but 300 mg/kg dihydropyridine had no effect on apolipoprotein B compared with the control group. Triiodothyronine was significantly increased by dietary dihydropyridine (P < 0.05). There were no differences in apolipoprotein A, cholesterol, trigly-cerides, high density lipoprotein-cholesterol, very low density lipoprotein-cholesterol, thyroxine and insulin among dietary treatments. It is concluded that supplementing dihydropyridine has a beneficial effect on feed efficiency and lipid metabolism of broilers, and that 200 mg/kg dihydropyridine supplementation is the optimum dose.

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Section: Discussionmentioning

confidence: 99%

Effects of dietary dihydropyridine supplementation on growth performance and lipid metabolism of broiler chickens

Niu¹,

Liu²,

Min³

et al. 2010

CZECH J ANIM SCI

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“…Interestingly, in intact animals, GSH concentration and activities of GSH-Px, GSSG-R, NADP-isocitrate dehydrogenase, and glucose-6-phosphate dehydrogenase increased after the administration of melatonin. However, in animals with toxic hepatitis, GSH concentration and these enzyme activities decreased after melatonin treatment, which was probably associated with an inhibition of free radical oxidation [137]. …”

Section: Protective Effects Of Melatonin On Hepatitismentioning

confidence: 99%

Effects of Melatonin on Liver Injuries and Diseases

Zhang

Meng

et al. 2017

IJMS

101

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Liver injuries and diseases are serious health problems worldwide. Various factors, such as chemical pollutants, drugs, and alcohol, could induce liver injuries. Liver diseases involve a wide range of liver pathologies, including hepatic steatosis, fatty liver, hepatitis, fibrosis, cirrhosis, and hepatocarcinoma. Despite all the studies performed up to now, therapy choices for liver injuries and diseases are very few. Therefore, the search for a new treatment that could safely and effectively block or reverse liver injuries and diseases remains a priority. Melatonin is a well-known natural antioxidant, and has many bioactivities. There are numerous studies investigating the effects of melatonin on liver injuries and diseases, and melatonin could regulate various molecular pathways, such as inflammation, proliferation, apoptosis, metastasis, and autophagy in different pathophysiological situations. Melatonin could be used for preventing and treating liver injuries and diseases. Herein, we conduct a review summarizing the potential roles of melatonin in liver injuries and diseases, paying special attention to the mechanisms of action.

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“…It is also possible that the generated NADPH would facilitate aflatoxin dialdehyde reduction as part of a detoxification strategy (Kelly et al, 2002). Moreover, aflatoxin treatment may deregulate glutathione metabolism, and the NADPH produced by this shunt may be used to maintain thiol pool homeostasis (Pashkov et al, 2005). We also note that glucose-6-phosphate dehydrogenase (G6pd) was increased in expression, although this enhancement did not reach the threshold for statistical significance.…”

Section: Discussionmentioning

confidence: 99%

Sulforaphane, a cancer chemopreventive agent, induces pathways associated with membrane biosynthesis in response to tissue damage by aflatoxin B1

Techapiesancharoenkij

Fiala

Navasumrit

et al. 2015

Toxicology and Applied Pharmacology

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Aflatoxin B1 (AFB1) is one of the major risk factors for liver cancer globally. A recent study showed that sulforaphane (SF), a potent inducer of phase II enzymes that occurs naturally in widely consumed vegetables, effectively induces hepatic glutathione S-transferases (GSTs) and reduces levels of hepatic AFB1-DNA adducts in AFB1-exposed Sprague Dawley rats. The present study characterized the effects of SF pre-treatment on global gene expression in the livers of similarly treated male rats. Combined treatment with AFB1 and SF caused reprogramming of a network of genes involved in signal transduction and transcription. Changes in gene regulation were observable 4 h after AFB1 administration in SF-pretreated animals and may reflect regeneration of cells in the wake of AFB1-induced hepatotoxicity. At 24 h after AFB1 administration, significant induction of genes that play roles in cellular lipid metabolism and acetyl-CoA biosynthesis was detected in SF-pretreated AFB1-dosed rats. Induction of this group of genes may indicate a metabolic shift toward glycolysis and fatty acid synthesis to generate and maintain pools of intermediate molecules required for tissue repair, cell growth and compensatory hepatic cell proliferation. Collectively, gene expression data from this study provide insights into molecular mechanisms underlying the protective effects of SF against AFB1 hepatotoxicity and hepatocarcinogenicity, in addition to the chemopreventive activity of this compound as a GST inducer.

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Glutathione System and Activity of NADPH-Generating Enzymes in the Liver of Intact Rats and Animals with Toxic Hepatitis Receiving Melatonin

Cited by 7 publications

References 6 publications

Effects of dietary dihydropyridine supplementation on growth performance and lipid metabolism of broiler chickens

Effects of dietary dihydropyridine supplementation on growth performance and lipid metabolism of broiler chickens

Effects of Melatonin on Liver Injuries and Diseases

Sulforaphane, a cancer chemopreventive agent, induces pathways associated with membrane biosynthesis in response to tissue damage by aflatoxin B1

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